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:: Volume 3, Number 4 (12-2013) ::
Iran J Ped Hematol Oncol 2013, 3(4): 138-142 Back to browse issues page
Evaluation of neuropathy during intensive vincristine chemotherapy for non-Hodgkin's lymphoma and Acute Lymphoblastic Leukemia
MD M Dorchin , MD R Masoumi Dehshiri, MD S Soleiman, MD M Manashi
Abstract:   (1652 Views)
Back ground: Vincristine (VCR), is a chemotherapy drug, useful in the treatment of leukemia, lymphoma and solid tumor and it is a potent neurotoxin and sensory neuropathy drug which a common behavioral toxicity of this drug. Neuropathy is common squeal of intensive chemotherapy protocols that contain vincristine and corticosteroids. Materials and Methods: This study was a retrospective and descriptive study of neuropathy during in chemotherapy program with vincristine for patients with non-Hodgkin's lymphoma (NHL) and Acute Lymphoblastic Leukemia (ALL). Data was analyzed by spss Version16 software. Results: From total of 51 cases, 23 patients had vincristine neuropathy (45%). Patients with visceral neuropathy have shown ileus, constipation in 13 patients (25%), occasionally severe diarrhea 11 (21%), mild diarrhea 7 (13.7%) and transient diarrhea in 16 patients (31%). Motor neuropathy were found in one patient with Bell, s palsy (1.9%) and one patient with Hoarseness. 12 patients (23.5%) had some type of complication together with sensory peripheral neuropathy. Conclusion: Almost half of patients with vincristin chemotherapy had neuropathy and the mean age of patients with neuropathy was 12.3 years.
Keywords: Vincristine; Neuropathy; Acute Lymphoblastic Leukemia; non-Hodgkin\'s lymphoma.
Full-Text [PDF 85 kb]   (667 Downloads)    
Type of Study: Research | Subject: Special
Received: 2013/12/18 | Accepted: 2013/12/18 | Published: 2013/12/18
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Dorchin M, Masoumi Dehshiri R, Soleiman S, Manashi M. Evaluation of neuropathy during intensive vincristine chemotherapy for non-Hodgkin's lymphoma and Acute Lymphoblastic Leukemia. Iran J Ped Hematol Oncol. 2013; 3 (4) :138-142
URL: http://ijpho.ssu.ac.ir/article-1-141-en.html
Volume 3, Number 4 (12-2013) Back to browse issues page
Iranian Journal of Pediatric Hematology and Oncology
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