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:: Volume 5, Number 2 (6-2015) ::
Iran J Ped Hematol Oncol 2015, 5(2): 113-115 Back to browse issues page
Successful Management of Vinblastin Overdose with Exchange Transfusion: A Case Report
Dr M Bordbar , Dr A Bazrafshan, Dr M Karimi
Abstract:   (977 Views)
Accidental overdose of chemotherapy drugs including vinblastin (VBL) have been reported in the literature. As VBL overdose is potentially fatal, we decided to introduce a 2-year-old girl affected by langerhans’ cell histiocytosis who was accidentally injected 10-times the prescribed dose of VBL (16 mg), and was saved with whole blood double exchange transfusion at 8 and 20 hrs after the accidental injection. The earliest manifestations were irritability and sinus tachycardia which alleviated after starting digoxin and at the end of the 2nd exchange transfusion. Other reported adverse effects were myelosuppression, weakness of extremities, diminished deep tendon reflexes and ileus which resolved at the time of discharge from hospital on day 13 of admission. It is speculated that exchange transfusion is an effective modality in reducing the serious adverse effects of VBL overdose.
Keywords: Vinblastin, Overdose, Exchange Transfusion
Full-Text [PDF 43 kb]   (293 Downloads)    
Type of Study: case report | Subject: Special
Received: 2015/05/30 | Accepted: 2015/05/30 | Published: 2015/05/30
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Bordbar M, Bazrafshan A, Karimi M. Successful Management of Vinblastin Overdose with Exchange Transfusion: A Case Report. Iran J Ped Hematol Oncol. 2015; 5 (2) :113-115
URL: http://ijpho.ssu.ac.ir/article-1-205-en.html
Volume 5, Number 2 (6-2015) Back to browse issues page
Iranian Journal of Pediatric Hematology and Oncology
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