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:: Volume 7, Issue 1 (2-2017) ::
Iran J Ped Hematol Oncol 2017, 7(1): 63-67 Back to browse issues page
Pleuropulmonary Blastoma: Report of 2 Cases
Nahid Reisi Dr , Saeed Yosefian Dr, Pardis Namatollahi Dr
MD Pediatric Oncologist, Associate Professor of Pediatric Hematology and Oncology, Faculty of Medicine, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Noncommunicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract:   (1106 Views)

Pleuropulmonary blastoma (PPB) is a rare, malignant intrathoracic tumor that occurs mostly in children before 5 years old. It consists about 15% of all primary pediatric pulmonary tumors and shows various mesenchymal components. Its presentations are nonspecific and common symptoms include fever, cough, chest pain, respiratory distress, and pulmonary infection. PPB should be considered in the differential diagnosis of solid and cystic lesions of thorax in children. Surgery is the main treatment of PPB that followed by chemotherapy. Radiotherapy has controversial effects on PPB. For recurrent tumors, bone marrow transplant is recommended. Two cases of this rare tumor is reported to increase the awareness about this entity and considering it in differential diagnosis of solid and cystic lesions of thorax in infants and children. The first case initially was treated with vincristine, actinomycin-D, and cyclophosphamide (VAC) regimen. Following relapse, it was scheduled with ifosfamide, vincristine, actinomycin-D and doxorubicin (IVADo) regimen and radiotherapy. Then, autologous stem cell rescue (ASCR) was recommended; but the patient was expired due to progressive disease before considering it. The second case was first treated with ifosfamide and doxorubicin alternate with ifosfamide and etoposide (IDo/ IE regimen). Following relapse, it was scheduled with ifosfamide, carboplatin and etoposide (ICE) chemotherapy regimen and he felt better.    

Keywords: Intrathoracic tumors, Pleuropulmonary blastoma, Pulmonary tumors
Full-Text [PDF 433 kb]   (336 Downloads)    
Type of Study: Research | Subject: Special
Received: 2016/12/18 | Accepted: 2016/12/18 | Published: 2016/12/18
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Reisi N, Yosefian S, Namatollahi P. Pleuropulmonary Blastoma: Report of 2 Cases . Iran J Ped Hematol Oncol. 2017; 7 (1) :63-67
URL: http://ijpho.ssu.ac.ir/article-1-288-en.html

Volume 7, Issue 1 (2-2017) Back to browse issues page
Iranian Journal of Pediatric Hematology and Oncology
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