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:: Volume 1, Number 2 (6-2011) ::
Iran J Ped Hematol Oncol 2011, 1(2): 57-61 Back to browse issues page
Effect of Glucantime on blood factors in patients with cutaneous leishmaniasis
Jamshid Ayatollahi , M Modares mosadegh, A Halvani
Abstract:   (9961 Views)
Abstract Background Glucantime is the first line agent for treatment of cutaneous leishmaniasis (CL). It has adverse effects on blood elements. This research has been done to evaluate the blood complications of this medicine in patients with cutaneous leishmaniasis. Methods This clinical trial was done at Nikpour clinic, Yazd, Iran. Blood samples were collected from patients diagnosed with CL before treatment and after receiving 20 mg/kg intramuscular glucantime. Injection every day for 20 days. Full cell blood count was done for all patients. Statistical analysis of data was achieved by paired-T-test using SPSS software (version 13). Results The blood tests results showed glucantime significantly decreased RBC, PLT, WBC (except monocytes), Hb and Hct (P< 0.05). MCH and PMN decreased but not significantly. MCV, MCHC and eosinophil count increased but not significantly. No correlation was seen between laboratory test results and patients' age and sex. Conclusion Glucantime affected the blood indices and it was suggested to use other alternating therapy. Future study with bigger sample size should be done for the more clear results. Keywords Glucantime, Cutaneous leishmaniasis, Blood
Keywords: Glucantime, Cutaneous leishmaniasis, Blood
Full-Text [PDF 178 kb]   (745 Downloads)    
Type of Study: Research | Subject: Special
Received: 2012/03/18
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Ayatollahi J, Modares mosadegh M, Halvani A. Effect of Glucantime on blood factors in patients with cutaneous leishmaniasis. Iran J Ped Hematol Oncol. 2011; 1 (2) :57-61
URL: http://ijpho.ssu.ac.ir/article-1-34-en.html
Volume 1, Number 2 (6-2011) Back to browse issues page
Iranian Journal of Pediatric Hematology and Oncology
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