Volume 13, Issue 1 (1-2023)                   Iran J Ped Hematol Oncol 2023, 13(1): 43-51 | Back to browse issues page


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Darbandi B, Ghorbannezhad N, Baghersalimi A, Koohmanaee S, Hassanzadeh Rad A, Atrkar Roshan Z, et al . Predicting Factors of Atherosclerosis in Children with Beta-Thalassemia Major. Iran J Ped Hematol Oncol 2023; 13 (1) :43-51
URL: http://ijpho.ssu.ac.ir/article-1-690-en.html
Guilan University of Medical Sciences, Rasht, Iran.
Abstract:   (487 Views)
Background: Atherosclerosis is an important cardiovascular disorder in beta-thalassemia major patients. The present study aimed to predict factors of atherosclerosis in children with beta-thalassemia major.
Materials and Methods: This cross-sectional study was conducted on 36 patients with beta-thalassemia major and 36 healthy children as the control group. The carotid intima-media thickness (CAIMT) and osteoprotegerin (OPG) were compared between groups.
Results: The mean age of the patients in the case and control groups were 13.5 ± 3.7 and 13 ± 3.1 years old, respectively. Significant differences in CAIMT in the right (P = 0.001) and left (P = 0.001) arteries were recorded between the two groups. The mean serum OPG in the beta-thalassemia group was significantly higher than the control group (3.9 ng/ml and 1.4 ng/ml, respectively, P=0.001).
Conclusion: CAIMT is a non-invasive method for diagnosing atherosclerosis. According to the significant difference between groups, serum OPG could be helpful in the diagnosis of early atherosclerosis in beta-thalassemia major.
Full-Text [PDF 306 kb]   (417 Downloads)    
Type of Study: Research | Subject: Heart
Received: 2021/11/29 | Accepted: 2022/02/28 | Published: 2023/01/20

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