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:: Volume 2, Issue 3 (9-2012) ::
Iran J Ped Hematol Oncol 2012, 2(3): 94-98 Back to browse issues page
Effect of 1/25 (OH)2-Vitamine D on Bone Mineral Density in Childhood Acute Leukemia
Z Namjou Bs, R Ghilian MD , A Hashemi MD, F Vojdanifard Bs, F Bakhshi Bs, Kh Dehghani Ms
Abstract:   (2835 Views)
Abstract Background Bone mineral density (BMD) may have occurred following treatment of Acute lymphoblastic Leukemia (ALL). 25-hydroxyvitamin D has been insufficiency described in these patients. In this Randomized Control Trial (RCT), we assessed the effectiveness of oral vitamin D administration after one year of treatment to protect bone density. Materials and Methods Twenty-four survivors of ALL patients (17 males and 7 females), who had completed their treatment with oral vitamin D supplement, at least 1 yr previously, and Twenty-five (20 males and 5 females) control group were examined with dual energy x-ray absorptiometry of the total body and L2–L4 vertebrae and neck of femur. Result Average of BMD (g/cm2) was significantly increased in oral vitamin D supplemented children (p=0.038) but average of Z-score decreased (p=0.006). Osteoporosis in this group was 4.2% and in control group, 40.9%. Conclusion Oral vitamin D supplementation to ALL children during 1 year did not show impact on Z-score and BMD (g/cm2). On the other hand, osteoporosis decreased in this group.
Keywords: Leukemia, Vitamin D, Bone Density
Full-Text [PDF 142 kb]   (749 Downloads)    
Type of Study: Research | Subject: Special
Received: 2012/09/16
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Namjou Z, Ghilian R, Hashemi A, Vojdanifard F, Bakhshi F, Dehghani K. Effect of 1/25 (OH)2-Vitamine D on Bone Mineral Density in Childhood Acute Leukemia. Iran J Ped Hematol Oncol. 2012; 2 (3) :94-98
URL: http://ijpho.ssu.ac.ir/article-1-77-en.html

Volume 2, Issue 3 (9-2012) Back to browse issues page
Iranian Journal of Pediatric Hematology and Oncology
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