Volume 7, Number 1 (2-2017) | ijpho 2017, 7(1): 57-62 | Back to browse issues page


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Karimi M, Cohan N, De Sanctis V. Thalassemia intermedia; folic acid and vitamin B12 supplementation. What we know and what is needed?. ijpho. 2017; 7 (1) :57-62
URL: http://ijpho.ssu.ac.ir/article-1-287-en.html

Abstract:   (421 Views)

This study presented a mini review on folic acid deficiency and recommendations for its supplementation in
thalassemia intermedia (TI). TI is a clinical condition which lies between thalassemia major and thalassemia
minor. Although TI patients may not need regular blood transfusion, precise diagnosis and management are
critical for the prevention of clinical complications and quality of life improvement. Blood transfusion, iron
chelation, and modulation of HbF are the main management strategies used for TI patients. High red blood cells
turnover and nutritional deficiency in thalassemic patients lead to some vitamins and minerals deficiency as well
as folic acid deficiency. Folic acid deficiency is more prevalent in TI patients compared with thalassemia major
because of fewer blood transfusion which leads to higher red cells turnover. Therefore, Daily folic acid
supplementation (1 mg/day) is recommended in these patients but the annual evaluation of vitamin B12
deficiency is also recommended in these patients for the prevention of its deficiency and complications

Full-Text [PDF 153 kb]   (289 Downloads)    
Type of Study: Research | Subject: Special
Received: 2016/12/18 | Accepted: 2016/12/18 | Published: 2016/12/18

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