Volume 7, Number 2 (3-2017) | ijpho 2017, 7(2): 82-89 | Back to browse issues page

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Tootoonchi P, Arjmandi K, Khosravi N. Neonatal Thrombosis: Incidence and Risk Factors in a Tertiary Care Hospital in Iran. ijpho. 2017; 7 (2) :82-89
URL: http://ijpho.ssu.ac.ir/article-1-292-en.html

Abstract:   (123 Views)

Background: Neonatal thrombosis is one of the most important challenges among patients admitted in
Neonatal Intensive Care Unit (NICU), which can lead to an asymptomatic condition, limb loss or even death.
This study was performed to determine the incidence and risk factors of neonatal thrombosis in a tertiary care
hospital in Tehran, Iran.
Material and Methods: In this historical cohort, all neonates admitted to Ali-Asghar children's hospital,
Tehran, from Sep 2014 till Mar 2015 were enrolled. If thrombosis happened and proved with Color Doppler
ultrasonography, the data about type and place of thrombosis, occurrence of complications, recurrence of
thrombosis, and the swelling of the extremity distal to the thrombosis area were collected. The statistical
significant level was set less than 0.05. SPSS (version 16) was used for data analysis.
Results: The neonatal thrombosis incidence was 2.87% (14 cases out of 489). Most of cases (13, 92.9%) had
venous thrombosis and one case (7.1%) had arterial thrombosis. Femoral vein thrombosis following catheter
insertion has occurred in 9 cases (64.2%) of thrombosis. In multivariate analysis with multiple regression, a
statistical significant relation was found between thrombosis and neonatal age at admission (P <0.0001), using
central vein catheter (P <0.0001), history of exchange transfusion (P <0.015), and exclusive breast feeding (P
<0.006) suggesting that lower age at admission, using of a central vein catheter or positive history of exchange
transfusion was an independent risk factor for thrombosis; using exclusive breast feeding had a protective effect
on thrombosis.
Conclusion: Most of our findings are in agreement with the results of other studies. Some interesting results
included the significant relation between thrombosis and neonatal age at admission, history of exchange
transfusion or exclusive breast feeding.

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Received: 2016/09/15 | Accepted: 2017/01/25 | Published: 2017/03/14
* Corresponding Author Address: Pediatric hematology and oncology ward, Ali Asghar hospital, Iran University of medical sciences, Tehran, Iran

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