TY - JOUR T1 - G6PD Enzyme Deficiency in Neonatal Pathologic Hyperbilirubinemia in Yazd TT - JF - SSU JO - SSU VL - 3 IS - 2 UR - http://ijpho.ssu.ac.ir/article-1-114-en.html Y1 - 2013 SP - 69 EP - 72 KW - Neonatal; Jaundice; Glucosephosphate Dehydrogenase Deficiency; Bilirubin; Favism N2 - Abstract Background About 7.5% of the world population carries one or two deficient copy of glucose-6-phosphate dehydrogenase (G6PD) genes. According to WHO, its prevalence in Iran is 10 to 14.9%. This study aimed on determination of frequency of G6PD deficiency in neonates with jaundice who were hospitalized during 6 months (September 2008 to February 2009) in the city of Yazd, Iran. Materials and Methods In this study, 105 icteric neonates in the hospitals of Yazd were evaluated. Data was collected from hospital records, and the G6PD activity was measured by photometric biochemical assay. Statistical analysis of data was performed by the SPSS-16 software, using Student's t-test and Pearson's chi-squared test. Results Between all of studied neonates, 19 (18.1%) had G6PD deficiency, and consisted of 15 boys (29.4% of boys) and 4 girls (7.4% of girls). In 100% of cases, the jaundice began in the first week after birth. The average total serum bilirubin at hospitalization was 17.22 mg/dL. In 31.5% of the G6PD-defficient neonates, exchange transfusion became necessary, which is significantly more than the rate in G6PD-sufficient (4.6%) neonates (P-value M3 ER -