AU - Darbandi, Bahram AU - Ghorbannezhad, Nasim AU - Baghersalimi, Adel AU - Koohmanaee, Shahin AU - Hassanzadeh Rad, Afagh AU - Atrkar Roshan, Zahra AU - Anvari, Saeid AU - Dalili, Setila AU - Tabrizi, Manijeh TI - Predicting Factors of Atherosclerosis in Children with Beta-Thalassemia Major PT - JOURNAL ARTICLE TA - SSU JN - SSU VO - 13 VI - 1 IP - 1 4099 - http://ijpho.ssu.ac.ir/article-1-690-en.html 4100 - http://ijpho.ssu.ac.ir/article-1-690-en.pdf SO - SSU 1 ABĀ  - Background: Atherosclerosis is an important cardiovascular disorder in beta-thalassemia major patients. The present study aimed to predict factors of atherosclerosis in children with beta-thalassemia major. Materials and Methods: This cross-sectional study was conducted on 36 patients with beta-thalassemia major and 36 healthy children as the control group. The carotid intima-media thickness (CAIMT) and osteoprotegerin (OPG) were compared between groups. Results: The mean age of the patients in the case and control groups were 13.5 ± 3.7 and 13 ± 3.1 years old, respectively. Significant differences in CAIMT in the right (P = 0.001) and left (P = 0.001) arteries were recorded between the two groups. The mean serum OPG in the beta-thalassemia group was significantly higher than the control group (3.9 ng/ml and 1.4 ng/ml, respectively, P=0.001). Conclusion: CAIMT is a non-invasive method for diagnosing atherosclerosis. According to the significant difference between groups, serum OPG could be helpful in the diagnosis of early atherosclerosis in beta-thalassemia major. CP - IRAN IN - Guilan University of Medical Sciences, Rasht, Iran. LG - eng PB - SSU PG - 43 PT - Research YR - 2023