RT - Journal Article T1 - Early Detection of Renal Dysfunction in β Thalassemia with Focus on Novel Biomarkers JF - SSU YR - 2020 JO - SSU VO - 10 IS - 1 UR - http://ijpho.ssu.ac.ir/article-1-513-en.html SP - 57 EP - 68 K1 - : β thalassemia K1 - Biomarkers K1 - Renal Insufficiency AB - Improved survival among transfusion dependent thalassemia patients in recent years has led to the manifestation of morbidities such as renal dysfunction. Renal injury is still an underestimated complication in β thalassemia major patients. Chronic anemia, iron overload due to repeated transfusion, and specific iron chelators are the main factors in pathogenesis of renal dysfunction in β thalassemia. Early identification of this morbidity allows us to delay the progression of kidney damage and therefore reduce renal impairment. In recent decades , novel biomarkers for early recognition of renal dysfunction have been studied in thalassemic patients, such as cystatin C, beta 2 microglobulin , alpha 1 microglobulin, N-acetyl beta-D-glucosaminidase (NAG), neutrophil gelatinase associated lipocaline (NGAL) , kidney injury molecule 1 (KIM-1) , liver type fatty acid binding protein (L-FABP), and retinol binding protein (RBP). In this review, renal aspects of thalassemia with focus on novel biomarkers were discussed. LA eng UL http://ijpho.ssu.ac.ir/article-1-513-en.html M3 10.18502/ijpho.v10i1.2170 ER -