TY - JOUR JF - SSU JO - Iran J Ped Hematol Oncol VL - 12 IS - 4 PY - 2022 Y1 - 2022/10/01 TI - Hematopoietic stem cell transplant therapy, clinical trials, complications, and quality of life for patients with Sickle cell anemia: Clinical potential and future perspectives TT - N2 - Background: Sickle cell anemia (SCA) is an inherited monogenic disorder. The clinical symptoms of SCA are protean, including vaso-occlusion, hemolysis, early stroke, leg ulcers, multi-organ failure, and increased risk of premature death. Hematopoietic stem cell transplantation is the only treatment identified to reduce SCA-related organ damage. Unfortunately, graft rejection is a significant impediment to these strategies. Materials and Methods: The current standard of treatment for the past two decades is limited to myeloablative-matched sibling donors, which is likely to be only for minor patients and is feasible for non-malignant giant disease. Cumulative studies showed that HSCT increases overall survival and quality of life in patients with SCA. Results: Hematopoietic stem cell transplantation (HSCT) is significantly associated with a higher risk of graft versus host disease and moderate mortality risk. New strategy lacking standard donors includes cord blood, matched unrelated donors/ Haploidentical donors. Conclusion: This review summarized evidence from HSCT clinical trials from different transplantation methods, specific HSCT and HSCT-related health problems that need to be addressed in medical contexts with patients and family members, and other areas that enhance the quality of life in SCA. SP - 272 EP - 302 AU - verma, Henu kumar AU - Ratre, Yashwant Kumar AU - Lvks, Bhaskar AU - sahu, Tarun AU - Lingojwar, Devendra Purushottam AD - Department of Immunopathology, Institute of lungs Biology and Disease, Comprehensive Pneumology Center, Helmholtz Zentrum, 85764 Neuherberg, Munich, Germany KW - Hemoglobinopathy KW - Hematopoietic stem-cell transplantation KW - Quality of Life KW - Sickle cell Anemia UR - http://ijpho.ssu.ac.ir/article-1-637-en.html DO - 10.18502/ijpho.v12i4.10918 ER -