Iranian journal of Pediatric Hematology and Oncology
Iranian journal of Pediatric Hematology and Oncology
Iran J Ped Hematol Oncol
Medical Sciences
http://ijpho.ssu.ac.ir
1
admin
2008-8892
2228-6993
8
7
14
8888
13
en
jalali
1393
6
1
gregorian
2014
9
1
4
3
online
1
fulltext
en
Heart repolarization changes after anthracycline therapy in the children with cancer
قلب
Heart
پژوهشي
Research
Background
Anthracyclines are important components of many chemotherapeutic protocols. The present study aimed to evaluate the repolarization changes in electrocardiography (ECG) which may predict drug induced arrhythmia.
Materials and Methods
In this cross-sectional study, the recorded ECGs were assessed for QT dispersion (QTd), QT corrected dispersion (QTcd), T peak to Tend dispersion (TPed), and P dispersion (Pd) in 12 ECG leads. The demographic information, including sex, age, and duration of drug consumption, were recorded, as well.
Results
In this study, 112 patients, including 58 females (52%) and 54 males (48%) with the mean age of 8.7±4.5 years, as the case group were compared with
43 children, including 17 males (40%) and 26 females (60%), in the control group. Most of our patients (88%) had received usual doses of anthracyclines i.e., 330 mg/m2. QT dispersion of the patients and the controls was 0.054±0.02 and 0.05± 0.02 seconds, respectively. No significant difference was found between the patients and the controls regarding corrected QT dispersion (P> 0.05). However, P dispersion time had increased in the patients' group. Our study showed that the duration of anthracyclines therapy did not cause any significant increase in ventricular re-polarization parameters.
Conclusion
Anthracyclines may show their cardiac toxicity through increasing P dispersion.
Anthracyclines, QT dispersion, corrected QT dispersion, P dispersion
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http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-70-20&slc_lang=en&sid=1
H
Amoozgar
اموزگار
No
S
Zareifar
زارعی فر
Yes
M
Borzoie
برزویی
No
F
Qasem
قاسم
No