Iranian journal of Pediatric Hematology and Oncology
Iranian journal of Pediatric Hematology and Oncology
Iran J Ped Hematol Oncol
Medical Sciences
http://ijpho.ssu.ac.ir
1
admin
2008-8892
2228-6993
8
7
14
8888
13
en
jalali
1394
5
1
gregorian
2015
8
1
5
3
online
1
fulltext
en
Serological Study on Cytomegalovirus and Toxoplasma Gondii in
قلب
Heart
پژوهشي
Research
Background
Beta-thalassemia patients receive blood products from blood transfusion centers repeatedly. Blood transfusion can transmit Cytomegalovirus (CMV) and Toxoplasma gondii. The aim of this study was serological evaluation of these two infectious agents in thalassemia patients.
Materials and Methods
In a cross-sectional study, the enzymelinked immunosorbent assay (ELISA) testing was performed to detect IgM and IgG antibodies against CMV and
Toxoplasma gondii in 96 thalassemia patients (under 18 years) and 144 healthy people. Data were analyzed by SPSS software and Chi-square test.
Results
A significant difference was observed in CMVIgM antibody levels between test group and control group in women (p<0.05). The prevalence of CMV IgM,
CMV IgG, Toxo-IgG, and Toxo IgM antibodies in thalassemia patients were 5.2%, 95.9%, 16%, and 0%, respectively.
Conclusions:
In all thalassemia patients, Cytomegalovirus IgG is higher than healthy people. In addition, CMV IgM antibodies are higher in female patients.
Antibody screening (IgM) on blood products for detecting Cytomegalovirus is necessary, but for Toxoplasma gondii is not necessary in the Yazd transfusion center.
Conclusion
In all thalassemia patients, Cytomegalovirus IgG is higher than healthy people. In addition, CMV IgM antibodies are higher in female patients. Antibody screening (IgM) on blood products for detecting Cytomegalovirus is necessary, but for Toxoplasma gondii is not necessary in the Yazd transfusion
center.
Beta-Thalassemia, Cytomegalovirus
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http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-70-52&slc_lang=en&sid=1
M
Doosti
No
HA
Vahedian-Ardakani
No
A
Talebi
No
M
Akhavan-Ghalibaf
No
A
Najafi
No
MM
Aminorroaya
No
Sh
Yazdani
No
M
Shayestehpour
Yes