Iranian journal of Pediatric Hematology and Oncology
Iranian journal of Pediatric Hematology and Oncology
Iran J Ped Hematol Oncol
Medical Sciences
http://ijpho.ssu.ac.ir
1
admin
2008-8892
2228-6993
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8888
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en
jalali
1395
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gregorian
2016
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online
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fulltext
ar
Effect of Sodium Bicarbonate and Sodium Chloride on Renal and Hematologic Factors in Patients with Glucose-6-phosphate Dehydrogenase Deficiency
قلب
Heart
پژوهشي
Research
<div>
<p><strong>Abstract</strong></p>
<p><strong>Background: </strong>Sodium bicarbonate serum therapy is used for compensation bicarbonate lost and increasing blood pH in metabolic acidosis caused by severe anemia in patient with glucose-6-phosphate dehydrogenase (G6PD) deficiency. The aim of present study was comparison the effect of serum therapy using two different serums (serum with bicarbonate and without bicarbonate) on some renal and hematologic factors and their side effects in patients with hemolysis caused by G6PD deficiency.</p>
<p><strong>Materials and Methods: </strong>In this clinical trial study, 79 patients with favism randomly put into two treatment groups, sodium bicarbonate and sodium chloride fluid therapy. During treatment, patients received blood based on hemoglobin (Hb). Duration of hospitalization, times of Blood transfusion, received blood volume, duration of cleaning UA of Hb, Hb, urine pH and granular casts in UA were evaluated.</p>
<p><strong>Results: </strong>The mean age of patients was 51.22 ± 37.86 months and there were 58 males and 21 females. Only duration of hospitalization and urine pH statistically showed a significant difference between two treatment groups (P=0.036 and P> 0.01, respectively), and other factors were statistically almost identical.</p>
<p><strong>Conclusion: </strong>The efficiency of sodium chloride was more than sodium bicarbonate in reducing the duration of hospitalization and the small clinical difference between received blood volumes, hemoglobin changes and duration of removing hemoglobin in UA, suggest, properly, sodium chloride can be more effective on improvement of hemolysis. Lack of side effects such as metabolic acidosis, heart damage and kidney failure in children can be due to controlled injection method, the concentration of soluble drugs and small size of studied population.</p>
</div>
Keywords: G6PD, Favism, Hemolysis, Hemolytic Anemia, Sodium Bicarbonate
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http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-70-94&slc_lang=ar&sid=1
Narges Beigom
Mirbehbahani
No
Associate professor, pediatric hematology and oncology, department of Pediatric Hematology and Oncology, Golestan University of Medical Sciences, Gorgan, Iran.
دانشگاه علوم پزشکی گرگان
Aysan
Salamikhanshan
No
Pediatric hematology and oncology, Taleghani Hospital, Gorgan, Iran.
بیمارستان طالقانی
Baranak
Safaian
No
Assistant professor, pediatric Nephrology, department of pediatric Nephrology, Golestan University of Medical Sciences, Gorgan, Iran.
دانشگاه علوم پزشکی گلستان
Sakineh
Mohammadian
No
Associate professor, pediatrician, Department of pediatric, Golestan University of Medical Sciences, Gorgan, Iran.
دانشگاه علوم پزشکی گلستان
Nasser
behnampour
No
Assistant professor, biology statistic, department of Hygiene , Golestan University of Medical Sciences, Gorgan, Iran.
دانشگاه علوم پزشکی گلستان
Safa
Ariannejad
No
Pediatrician, Department of pediatric, Taleghani Hospital, Gorgan, Iran.
بیمارستان طالقانی
Ali Reza
Masoomnia
No
Pediatric Hematology and Oncology, Department of Pediatric Hematology and Oncology, Taleghani Hospital, Gorgan, Iran.
بیمارستان طالقانی
Azin
Malekmarzban
No
Hemophilia and Thalassemia Research Center, Tleghani Hospital, Gorgan, Iran.
بیمارستان طالقانی
Azam
Rashidbaghan
rashidbaghan@yahoo.com
Yes
Ph.D Candidate, Cellular and Molecular Biology, Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
دانشگاه علوم پزشکی کرمانشاه