Iranian journal of Pediatric Hematology and Oncology
Iranian journal of Pediatric Hematology and Oncology
Iran J Ped Hematol Oncol
Medical Sciences
http://ijpho.ssu.ac.ir
1
admin
2008-8892
2228-6993
8
7
14
8888
13
en
jalali
1400
10
1
gregorian
2022
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12
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online
1
fulltext
fa
Evaluating the blood toxicity of functionalized graphene-arginine with anticancer drug ginsenoside Rh2 in balb/c mouse model with breast cancer
قلب
Heart
پژوهشي
Research
<div><strong>Background: </strong>Gensenoside Rh2 is an anticancer drug with low toxicity and stability in the body. The aim of this study was to evaluate the blood toxicity of functionalized graphene-arginine with anticancer drug ginsenoside Rh2 in balb/c mouse model with breast cancer.<br>
<strong>Materials and Methods: </strong>Graphene-Arginine (G-Arg) and Graphene-Arginine-ginsenoside Rh2 (G-Arg-Rh2) were synthesized using microwave method. For evaluation of blood toxicity, 32 mice with breast tumors were randomly divided into 4 groups: control (3mg/kg 6 mg/kg PBS sterile), group 1 (6 mg / kg ginsenoside), group 2 (3 mg / kg G-Arg), and group 3 (3 mg/kg G-Arg-Rh2). Treatment was done intravenously once every three days for 32 days. Finally, blood factors were also examined by sampling from the heart.<br>
<strong>Results: </strong>Complete functionalization was proven by FTIR and Raman. Examination of blood factors showed that white blood cells had a very small increase. Anova test showed significant difference among four groups in term of WBC count (p=0.016). Pair sample T test showed that there was significant difference between control and group 1(p=0.036) and control and group 2 (p=0.036). There was no significant difference between control and group 3 (p=0.051). Other blood factors had no significant difference among examined groups (p>0.05).<br>
<strong>Conclusion: </strong>Based on results, after treatment with all designed nanostructures, only white blood cells had a very small increase and inflammatory reactions were statistically similar in all groups. This indicates the high efficiency of designed drug.</div>
Gensenoside Rh2, balb/c mouse, Graphene-Arginine, Graphene-Arginine-ginsenoside Rh2, blood
10
16
http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-869-2&slc_lang=fa&sid=1
Shervin Dokht
Farhangfar
No
Department of Biology, Science and Arts University, Yazd, Iran
Department of Biology, Science and Arts University, Yazd, Iran
Farzaneh
Fesahat
0000-0002-3743-4449
No
Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Sayed Mohsen
Miresmaeili
No
Department of Biology, Science and Arts University, Yazd, Iran
Department of Biology, Science and Arts University, Yazd, Iran
Hadi
Zare-Zardini
hadizarezardini@gmail.com
0000-0002-1501-2560
Yes
Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran