Iranian journal of Pediatric Hematology and Oncology
Iranian journal of Pediatric Hematology and Oncology
Iran J Ped Hematol Oncol
Medical Sciences
http://ijpho.ssu.ac.ir
1
admin
2008-8892
2228-6993
8
7
14
8888
13
en
jalali
1391
9
1
gregorian
2012
12
1
2
4
online
1
fulltext
en
Assessment of antibody titers and immunity to Hepatitis B in children receiving chemotherapy
قلب
Heart
پژوهشي
Research
Abstract
Background
There is a decrease in vaccine-specific antibody to certain vaccine-preventable diseases in children after chemotherapy, but the frequency of non-immune patients is not clear. In the present case-control study, was taken under investigation protection level to Hepatitis B infection in children 6 months after completing chemotherapy.
Materials and Methods
In this study 68 patients with cancer and 68 healthy children were enrolled. Patients were 1.5 -12 years old with completed standard chemotherapy at least for 6 months. All the patients and healthy children were negative for HBsAg and HBeAg and had received Hepatitis B vaccination. IgG antibody concentrations against Hepatitis B Virus (HBV) were determined in the patients receiving chemotrapy and healthy subjects serum by ELISA method. IgG antibody titer > 10 mIU/ml was considered as baseline protective titer for preventing HBV infection.
Results
Anti-HBs antibody titer in 19.12% of patients was less than 10 mIU/ml and 11.76% of the patients had borderline antibody titer (10-20 mIU/ml). In healthy subjects, 2.94% and 5.88% had antibody titer < 10 mIU/ml and 10-20 mIU/ml, respectively. According to statistical analysis, frequency of non immune subjects in children with cancer was significantly higher than those in healthy children (P-value=0.024).
Conclusion
HBV vaccination post-intensive chemotherapy in the children with cancer is strongly recommended.
Hepatitis B, Vaccination, Immunity
133
139
http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-1-57&slc_lang=en&sid=1
A
Shams Shahemabadi
Yes
F
Salehi
No
A
Hashemi
No
M
Vakili
No
F
Zare
No
N
Esphandyari
No
S
Kashanian
No