Iranian journal of Pediatric Hematology and Oncology
Iranian journal of Pediatric Hematology and Oncology
Iran J Ped Hematol Oncol
Medical Sciences
http://ijpho.ssu.ac.ir
1
admin
2008-8892
2228-6993
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8888
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en
jalali
1391
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1
gregorian
2012
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online
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fulltext
en
Assessment Hepatomegaly and liver Enzymesin 100 Patients with beta Thalassemia Major in Mashhad, Iran
قلب
Heart
پژوهشي
Research
Abstract
Background
Frequent blood transfusion in patients with beta thalassemia major can lead to iron overload especially in liver. Chronic iron overload could cause cirrhosis of the liver. Transfusion- transmitted hepatitis B and C also could develop cirrhosis in individuals.
Materials and Methods
The present cross- sectional descriptive study is to assess hepatomegaly and liver enzymes in 100 patients with beta thalassemia major, ages between 2-18 years old. The study was carried out retrospectively. One hundred medical records have chosen from 400 samples of thalassemia major patients, who are under a regular care of the department of sarvar clinic.
Results
Out of these patients, 55% were male and 45% female. The mean age of thalassemia patients was 10.8 4.4 years. The mean and S. D of hemoglobin, ferritin, deferoxamine dosage was 8.5 ± 1.5g/dl , 2183 ± 1528 ng , 30 ± 11.16 mg/kg, respectively. Forty six percent of them had hepatomegaly. The mean and S. D of AST and ALT were 95± 70 IU/L and 70 ±35U/L respectively. Splenectomy was performed on 44% of patient.
Conclusion
Hepatomegaly is one of the most common findings in the thalassemic patient that induced with hemosiderosis and hepatitis.
Epidemiology, Hepatomegaly, Liver, beta-Thalassemia
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http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-1-63&slc_lang=en&sid=1
H
Hashemizadeh
Yes
R
Noori
No
SH
kolagari
No