eng
Shahid Sadoughi University of Medical Sciences, Yazd
Iranian Journal of Pediatric Hematology and Oncology
2008-8892
2228-6993
2016-03
6
1
1
8
article
Implantable Port Devices, Complications and outcome in Pediatric Cancer, a Retrospective Study
H Esfahani
1
M Ghorbanpor
2
A Tanasan
3
Abstract
Background
Peripheral blood vessels, due to availability are used for many years in cancer patients, however in patients with potentially harmful drugs to skin (vesicant drugs) or difficult accessibility to vessels, the use of implantable port (totally implantable venous access port-TIVAP)devices with central vascular access are important.
Materials and Methods
In this retrospective study, 85 pediatric cancer patients younger than 16 years, with TIVAP implantation, were followed
for their complications and outcome. In addition to demographic data, patients’ port complications were assessed and
compared with published articles.
Results
Mean days of implanted port usage were 531 ± 358 days in all patients. This period was 287 ±194 days in complicated
patients. Complications included as infection (tunnel infection and catheter related blood-stream infection), malfunction and thrombosis, skin erosion, tube avulsion, and tube adhesion to the adjacent vessels were seen in 30.6% of patients.
Conclusion
According to the published data and this experience, the most common complications in TIVAP are infection and catheter malfunction. It is important to notice that in order to prolong its efficacious life, effective sterilization methods, prevention of clot formation and trauma, are the most useful measures.
http://ijpho.ssu.ac.ir/article-1-236-en.pdf
Adverse effects
Complications
Malignancy
Pediatric
Vascular access device
eng
Shahid Sadoughi University of Medical Sciences, Yazd
Iranian Journal of Pediatric Hematology and Oncology
2008-8892
2228-6993
2016-03
6
1
9
14
article
Effect of Chewing Gum on Oral Mucositis in Children Undergoing Chemotherapy: A Randomized Controlled Study
A Eghbali
1
B Taherkhanchi
2
B Bagheri
3
B Sadeghi Sedeh
4
Background
Oral mucositis is an adverse effect of chemotherapy. Type of chemotherapy regimen is the most important factor causing
mucositis. Oral mucositis is usually associated with transient decrease in saliva production. The goal was to study effects of
gum consumption on oral mucositis in children undergoing chemotherapy.
Materials and Methods
This randomized controlled trial was done in Amir Kabir Hospital, Arak, Iran. 130 children 5 to 15 years of age were studied.
Control group was composed of 65 children who received mucotoxic drugs. Test group was made up of 65 patients received similar drugs in addition to sugar free gums. Patients consumed 6 pieces of gums per day for 15 days. A standardized follow up form and World Health Organization (WHO) grading system for oral mucositis were used for evaluation of patients during 15 days of treatment.
Results
Severe oral mucositis occurred in 30 (46%) of 65 patients in the test group and in 26 of 65 (40%) patients in the control group.
Difference was not statistically significant (P > 0.05). Rate of mild to moderate mucoitis (grade 1 and 2) was significantly lower in patients who used gums (15 % vs. 35%, P < 0.05).
Conclusion
Our study showed that stimulation of saliva flow by chewing gum could decrease mild to moderate inflammatory injuries of the
oral mucosa during chemotherapy. However, it was not effective to subside severe mucositis.
http://ijpho.ssu.ac.ir/article-1-237-en.pdf
Chemotherapy
Children
Gum
Mucositis
eng
Shahid Sadoughi University of Medical Sciences, Yazd
Iranian Journal of Pediatric Hematology and Oncology
2008-8892
2228-6993
2016-03
6
1
15
23
article
Incidence and Trend of Childhood and Adolescent Cancers in Yazd, Iran
F Binesh
1
A Hashemi
2
M Vakili
3
MM Shakeri
4
R Masoumi Dehshiri
5
Abstract
Background
Data on childhood and adolescent malignant tumors incidence are skimp in developing countries. In this study, we analyzed the incidence and trend of childhood and adolescent cancers in Yazd city, center of Iran between Jan 2004 and Dec 2013.
Materials and Methods
The various types of malignant tumors were grouped pursuant to the International Classification for Cancer in Children. To
analyze the data, descriptive and illative statistical methods were used.
Results
Two hundred twenty-two patients with a malignancy aged less than 18 years were studied with a male to female ratio of
1.36.The mean age of patients was 9.88 (±5.7) years. Leukemia with the frequency of 84 (37.8%) and after that lymphoid
malignancies with the frequency of 49 (22.1%) were the most common cancers. There was a low range of oscillation in the
incidence rate of malignancies during this period of time (P value= 0.081). Malignancies were mostly in males (P value=0.057) but the whole process of malignancy incidence had gone toward the higher rate of incidence in females. Incidence rate of cancers types was steady. Malignancy incidence was 3-7 cases in hundred of thousands except a year of which this incidence rate was estimated 13.4.
Conclusion
Leukemias and lymphomas were the main cancers in the center of Iran. Childhood and adolescent malignancies may be
considerably under-recorded in our province .A childhood and adolescent cancer registry is necessary for exact analysis of these types of malignancies.
http://ijpho.ssu.ac.ir/article-1-238-en.pdf
Adolescent
Cancer
Childhood
Incidenc.
eng
Shahid Sadoughi University of Medical Sciences, Yazd
Iranian Journal of Pediatric Hematology and Oncology
2008-8892
2228-6993
2016-03
6
1
24
31
article
Clinical Features and Treatment Outcomes of Primary Immune Thrombocytopenic Purpura in Hospitalized Children Under 2-Years Old
H Farhangi
1
A Ghasemi
2
A Banihashem
3
Z Badiei
4
L Jarahi
5
G Eslami
6
T Langaee
7
Abstract
Background
Immune thrombocytopenic purpura (ITP) is the most prevalent cause of thrombocytopenia in children. Despite the importance of ITP in children under 2- years old, only a few publications are available in the literature. ITP usually presents itself as isolated thrombocytopenia and mucocutaneous bleeding.
Materials and Methods
This study was conducted on 187 under 2- year-old children diagnosed with ITP and treated at Dr. Sheikh Hospital from 2004
to 2011.In this retrospective study, clinical symptoms, laboratory findings, history of viral infections, vaccination history, and
treatment efficacy in children under 2- years old with ITP were investigated.Patients were followed for one year after being discharged from the hospital.
Results
The risk of the disease developing into chronic form was higher in older children (0.001). ITP in children under 3-months
old was significantly associated with vaccination (p=0.007). There was no significant differences between male and female patients in regards to newly diagnosed ITP, persistent, and chronic disease status (p = 0.21). No significant difference in bleeding symptoms was observed between patients under 3-months old and 3 to 24-months old (p=0.18).
Conclusion
Infantile ITP respond favorably to treatment. The risk of the disease developing into chronic form is higher in 3-to-24-month-old children compared to under-three-month olds.
http://ijpho.ssu.ac.ir/article-1-239-en.pdf
ITP
Intravenous Immune Globulin
Pediatric
Platelet
Vaccination.
eng
Shahid Sadoughi University of Medical Sciences, Yazd
Iranian Journal of Pediatric Hematology and Oncology
2008-8892
2228-6993
2016-03
6
1
32
37
article
Evaluation Efficacy of Ferrous Sulfate Therapy on Headaches of 5-15 Years Old Iron Deficient Children with Migraine
R Fallah
1
S Zare Bidoki
2
M Ordooei
3
Abstract
Background
Some researches have shown the association between iron deficiency and migraine headache in adults. The aim of present study was to evaluate efficacy of ferrous sulfate treatment on migraine headaches of 5-15 years old migraineur children with iron deficiency.
Materials and Methods
In a quasi- experimental study, monthly frequency, severity, duration and disability of headaches of 5-15 years old migraineur
children that prophylactic therapy was indicated in them and had iron deficiency who were referred to Pediatric eurology Clinic of Shahid Sadoughi University of Medical Sciences, Yazd, Iran between 2013 and 2015 and were treated with 2mg/kg/day topiramate plus 4mg/kg/day of ferrous sulfate for three consecutive months, were evaluated and headache characteristics before and after treatment were compared.
Results
In this study, 98 children with mean age of 9.72±3.19 were evaluated that 31children (31.6%) had iron deficiency. Monthly
frequency (22.89±7.18 vs.14.5±4.56, P= 0.02), severity score (8.12± 1.76 vs. 5.03±1.15, P= 0.02) and disability score of
headache (38.23±10.7vs. 30.12±7.46, P= 0.03) were more in children with iron deficiency. Iron therapy was effective in
decreasing of monthlyfrequency 22.89± 7.18 vs. 10.13±4.51, P = 0.001), severity score (8.12±1.76 vs. 5.11±1.62, P =0.001),
duration (2.14±1.23 vs.1.14±1.01, P= 0.001) and disability score of headache (38.23±10.7 vs. 22.87±8.65, P= 0.01).
Conclusion
In children, iron deficiency increased monthly frequency, severity and disability of migraine headache and ferrous sulfate
can be used as a safe and effective drug in migraine prophylaxis.
http://ijpho.ssu.ac.ir/article-1-240-en.pdf
Adverse effects
Malignancy
Pediatric
Complications
Vascular access device
eng
Shahid Sadoughi University of Medical Sciences, Yazd
Iranian Journal of Pediatric Hematology and Oncology
2008-8892
2228-6993
2016-03
6
1
38
42
article
Hematological Indices in Children with Non-organic Failure to Thrive: a Case-Control Study
AH Jafari Nodoshan
1
A Hashemi
2
A Golzar
3
F Karami
4
R Akhondzaraini
5
Background
Non-organic failure to thrive (NFTT) is the most common cause of failure to thrive (FTT) which is attributed to inadequate
nutrition due to economic factors or parental neglect. NFTT can lead to a vicious cycle of poor and inadequate eating and severity of anemia. The aim of this study was to determine the hematological indices in children with NFTT.
Materials and Methods
In a cross sectional case control study, iron status and blood indices of forty five aged 6–60 months children with NFTT were
evaluated and compared with 45 healthy control children (with matching of age and sex).
Results
In this study, the prevalence of anemia was 48.9% in NFTT compared to 11.4% in the control group (p<0.001). Microcytic
anemia was significantly more prevalent among the subjects than the controls (77.8% versus 27.3%; p<0. 001). The serum iron level was 73.2 and 62.8 mcg/dl for the case and control groups (P=0.29). The ferritin level in the study group was 29.8 versus 35.47 ng/ml in the control group (p=0.227). The prevalence of iron deficiency anemia among children with mild, moderate, and severe underweight was 44.4%, 45.5%, and 48%, respectively. The highest prevalence of iron-deficiency
anemia was seen between age group of 12 and 24 months (p<0.05).
Conclusion
Based on the results of this study, a correlation between malnutrition and anemia was found. However, further
studies are needed to assess and confirm the current outcomes.
http://ijpho.ssu.ac.ir/article-1-241-en.pdf
Ferritin
Hematological indices
Non- Organic Failure to Thrive
eng
Shahid Sadoughi University of Medical Sciences, Yazd
Iranian Journal of Pediatric Hematology and Oncology
2008-8892
2228-6993
2016-03
6
1
43
51
article
Candidiasis in Pediatrics; Identification and In vitro Antifungal Susceptibility of the Clinical Isolates
R Mohammadi
1
B Ataei
2
Background
Candida species are normal microflora of oral cavity, vagina, and gastrointestinal tract. They are the third most prevalent
cause of pediatric health care–associated bloodstream fungal infection. This study aimed to provide an epidemiological
feature of candidiasis and also presents an antifungal susceptibility profile of clinical Candida isolates among children.
Materials and Methods
During July 2013 to February 2015, 105 patients from different hospitals of Isfahan, Iran, were examined for candidiasis by
phenotypic tests. Samples were obtained from nail clippings, blood, thrush, BAL, urine, oropharynx, skin, and eye discharge.
The age range of patients was between 18 days to 16 years. Genomic DNA of isolates was extracted and ITS1- 5.8SrDNA-ITS2 region was amplified by ITS1 and ITS2 primers. The PCR products were digested using the restriction enzyme MspI. Minimum inhibitory concentration (MICs) was determined using microdilution broth method according to the clinical and laboratory standards institute (CLSI) M27-A3 and M27-S4 documents.
Results
Forty-three patients (40.9%) had Candida infection.The most clinical strains were isolated from nail infections (39.5%), and
candidemia (13.9%). Candida albicans was the most prevalent species (46.5%). MICs ranges for amphotericin B, fluconazole, and itraconazole were (0.025- 0.75 μg/ml), (0.125-16 μg/ml), and (0.094- 2 μg/ml), respectively.
Conclusion
Due to high incidence of Candida infections among children, increasing of fatal infection like candidemia, and emersion of antifungal resistance Candida isolates, early and precise identification of the Candida species and determination of antifungal susceptibility patterns of clinical isolates may lead to better management of the infection.
http://ijpho.ssu.ac.ir/article-1-242-en.pdf
Antifungal susceptibility
Candidemia
Pediatrics
eng
Shahid Sadoughi University of Medical Sciences, Yazd
Iranian Journal of Pediatric Hematology and Oncology
2008-8892
2228-6993
2016-03
6
1
52
63
article
Association Between RFC1 G80A Polymorphism and Acute Lymphoblastic Leukemia: a Review and Meta-Analysis of 10 Studies
M Forat-Yazdi
1
F Hosseini-Biouki
2
J Salehi
3
H Neamatzadeh
4
R Masoumi Dehshiri
5
Z Sadri
6
F Ghanizadeh
7
R Sheikhpour
8
H Zare-Zardini
9
Background
Evidence indicates RFC1 G80A polymorphism as a risk factor for a number of cancers. Increasing studies have been conducted on the association of RFC1 G80A polymorphism with acute lymphoblastic leukemia (ALL) risk. However, the results were controversial. The aim of the present study was to derive a more precise estimation of the relationship.
Materials and Method
PubMed, Embase, Web of Science, Cochrane database, and Google Scholar were searched to get the genetic association studies between RFC1 G80A polymorphism and ALL. All eligible studies for the period up to February 2016 were identified. Subgroup analyses regarding ethnicity were also implemented. All statistical analyses were done with CMA 2.0.
Results
A total of ten studies comprising of 2,168 ALL cases and 2,693 healthy controls were included in this meta-analysis. Overall, no significant association was detected for allelic model (OR = 1.029, 95 % CI 0.754- 1.405, P=0.000), Dominant model (OR = 1.619, 95 % CI 0.847-3.094, P=0.145), recessive model (OR = 1.169, 95 % CI 10.764-1.790, P=0.429), and homozygote model (OR = 1.288, 95 % CI 0.928-1.788, P=0.130). However, there was an obvious association under the heterozygote model (OR = 1.368, 95 % CI 1.056- 1.772, P=0.018). Also, in the stratified analysis by ethnicity, no significant association of this polymorphism with risk of OC was found in the Asian and Caucasian populations. However, there was not significant
heterogeneity between heterozygote genetic model (P = 0.15, I2 = 33%) in Caucasian. Therefore, we utilized the fixed-effect model to merge OR value.
Conclusion
Based on the available evidence, no association between RFC1 G80A Polymorphism and ALL risk was observed, even in the subanalysis by ethnicity. The direction of further research should focus not only on the simple relationship of RFC1 G80A Polymorphism and ALL risk, but also on gene–gene and gene-environment interaction.
http://ijpho.ssu.ac.ir/article-1-245-en.pdf
Acute lymphoblastic leukemia
Genetic polymorphism
G80A Polymorphism
Meta-analysis
RFC1.
eng
Shahid Sadoughi University of Medical Sciences, Yazd
Iranian Journal of Pediatric Hematology and Oncology
2008-8892
2228-6993
2016-03
6
1
64
69
article
Severe Anemia and Helicobacter Pylori Infection in school age Children; A case reports
Sh Gheibi
1
M Noroozi
2
S Hejazi
3
M Karamyyar
4
H Farrokh-Eslamlou
5
Abstract
Background
Iron-deficiency anemia is a widespread public health problem with major consequences for human health especially, children. However, in a fraction of patients an underlying cause is never found during routine investigation. Recent studies have
suggested an association between Helicobacter pylori (H. Pylori) infection and iron-deficiency anemia.
Case presentation
Here is reported four school aged children (two male, two female) with refractory severe iron-deficiency anemia associated
H. Pylori gastritis. Mean age of the patients was 13.62 years old and they were admitted with chief complaints of abdominal, chest pain weakness, headache and respiratory distress. Mean hemoglobin level in patients was 6.2 g/dl with persistence to iron therapy. After the diagnosis and therapy of H. pylori infection, clinical complaints, hemoglobin level and iron profiles were being normal and they gained weight.
Conclusion
This study suggests screening of H. pylori infection and appropriate treatment in any case of refractory moderate to severe irondeficiency anemia, especially with clinical manifestations of gastrointestinal tract in children.
http://ijpho.ssu.ac.ir/article-1-244-en.pdf
Helicobacter pylor
Iron deficiency
Severe Iron deficiency anemia