@article{ author = {Mirmohammadi, Seyed Jalil and Hashemi, Azam sadat and Souzani, Azadah and Dehghani, khadijeh and Atefi, Atef and ZareianYazdi, Zahr}, title = {Environmental Risk Factors for Acute Leukemia and Non-Hodgkin Lymphoma in Children}, abstract ={Abstract Objective The incidence of childhood cancer has been increasing nearly one percent per year for the past two decades. Leukemia and lymphoma are the most common types of childhood cancers. This study assessed the relation between environmental factors (Hydrocarbon, agricultural toxin, insecticide) and leukemia/lymphoma in children, which was evaluated by the frequency of the parents’ hazardous occupations, and their smoking, drug addiction, and alcoholism habits. Methods This was a case-control study on 86 children with leukemia and non-Hodgkin's lymphoma and 188 healthy controls from March 2007 till March 2010. They were matched in age and sex. Information was gathered via a questionnaire and analyzed by SPSS 15. Result There were 32 (37.2%) girls and 54 (62.8%) boys in the case group and the majority were 3-5 years old. In case group fathers’ occupations were mostly farmers 50 (58.1%), followed by painter or exposed to hydrocarbons 14 (16.6%), but in the control group, farmers were 17 (19.7%), and painters or those exposed to hydrocarbons were 5 (5.8%). The frequency of fathers' various occupations was significantly different between cases and controls. In addition, smoking, drug addiction and alcoholism was significantly higher in cases fathers than controls fathers. Conclusion The frequency of leukemia and non-Hodgkin's lymphoma in children whose father were painters, exposed to hydrocarbons and farmers are higher than normal children. So people with these occupations should pay more attention and should be protected against these risk factors. The history of addiction and alcoholism was higher in their father.}, Keywords = {Acute Leukemia, Non-Hodgkin Lymphoma, Environmental Factor}, volume = {1}, Number = {1}, pages = {1-3}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-21-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-21-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2010} } @article{ author = {Shahvazian, Najme and Hashemi, Azam sadat and Shakiba, Mehrdad and Farahzadi, Mohammad Hosein and Mahmoodabadi, Fatemeh}, title = {Efficacy of Chicory in Decreasing Serum Ferritin and Liver Enzymes in Major Beta Thalassemia Patients}, abstract ={Abstract Objective Thalassemia major is a severe transfusion-dependent anemia that needs iron chalation therapy to remove iron overload. The objectives of the present study were to assess the iron overload liver response to inulin of chicory supplementation by evaluating the serum ferritin and liver enzymes. Methods Among 70 beta thalassemia patients, 50 were selected for chelating therapy using inulin of chicory. The initial dose was 1gr given twice a day. Twenty patients were excluded because of Hepatitis B and C and cardiac heart failure. Results From 50 patients, 47 patients tolerated chicory, which the majority showed dramatic responses. Mean serum ferritin level decreased from 3563.09 ng/ml to 1728.54 ng/ml. Mean serum AST level decreased from 25.44 u/lit to 22.25 u/lit. Mean serum ALT level decreased from 30 .861u/lit to 25.085u/iit. Serum ferritin level decreased significantly after treatment (PV≈ 0.00), but there was no significant difference in AST (PV=0.379) and Alt (0.367) after chicory treatment. Conclusion The present results suggest that chicory can reduce iron over load and liver enzymes. Significant differences in serum ferritin were found during intervention, but not in LFT enzymes.}, Keywords = {Major beta thalassemia, Chicory, Ferritin, Liver enzymes}, volume = {1}, Number = {1}, pages = {4-7}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-22-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-22-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2010} } @article{ author = {Hashemi, azam Sadat and Najafi, Neda and Behnaz, Fatemeh and Zare, Asghar}, title = {Oral Ciprofloxacin Compared with Intravenous Ceftazidim on Low Risk Febrile Neutropenia in Acute Lymphocytic Leukemia}, abstract ={Abstract Objective Fever and neutropenia are a common complication of chemotherapy in cancer. It is usually managed by hospitalization and empiric administration of antibiotics. Use of Fluroquinolones is limited because of joint/cartilage toxicity. This study attempted to compare the efficacy of oral ciprofloxacin with intravenous ceftazidim in low risk febrile neutropenic lymphocytic leukemia. Methods Ninety two episodes of febrile neutropenia in 72 patients under 14 years old were studied prospectively for two years. All the patients received G-CSF plus intravenous ceftazidim 100 mg/kg/d and amikacin 15 mg/kg/d for 24 hours. These episodes randomly allocated into two groups. Group A received IV ceftazidim and amikacin for at least 3 days. After discharge they got oral cefixim 8 mg/kg daily. Group B discharged and received oral ciprofloxacin (20 mg/kg.day) for seven days. Failure was defined as temperature higher than 38 °C for more than 72 hours or major complication. Results Failure of intravenous ceftazidim plus amikasin for at least 4 days in hospital, in low risk febrile neutropenic children, was 6.5%, but failure of oral ciprofloxacin for 7 days after 24h intravenous ceftazidim plus amikasin was 4.3%. There was no arthrotoxicity in patients received ciprofloxacin. Conclusion Empirical therapy with oral ciprofloxacin is safe and effective in children with leukemia and low risk FN.}, Keywords = {Ciprofloxacin, Neutropenia, Acute Lymphocytic Leukemia}, volume = {1}, Number = {1}, pages = {8-13}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-23-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-23-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2010} } @article{ author = {Keikhaei, Bij}, title = {Sequential Deferoxamine - Deferasirox in Treatment of Major Thalassemia with Iron Overload}, abstract ={Abstract Background Iron overload is a major problem in patients with major thalassemia. An effective and safe iron chelator protocol with high compliance rate plays an important role in treatment of these patients. This study was done to assess the efficacy and safety of the sequential deferoxamine and deferasirox protocol in major thalassemia patients in Khuzestan province, Iran. Material and Method Sixty two patients were studied aged between 2 to 30 years old. A regimen consisted of 4 days deferasirox followed by 3 days deferoxamine. The duration of trial was 6 months. The efficacy was determined by comparison of ferritin level before and after treatment. Results Serum ferritin changed from 3590 ng/ml to 2563 ng /ml, which decreased significantly. During study 21% of patients experienced at least one side effect. Conclusion This is a new regimen with high efficacy, low toxicity and acceptable compliance.}, Keywords = {Sequential, Deferoxamine, Deferasirox, Major thalassemia.}, volume = {1}, Number = {1}, pages = {14-18}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-24-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-24-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2010} } @article{ author = {Hashemi, Azam Sadat and Shahvazian, Najme and Zarezade, Asghar and Shakiba, Mehrdad and Atefi, Atef}, title = {Frequency of Tumor Lysis Syndrome in Aggressive and Slow Introduction Chemotherapy in Children with ALL}, abstract ={Abstract Background Tumor Lysis Syndrome (TLS) is an oncologic emergency that results from massive lysis of malignant cells. The incidence of TLS depends on the risk factors, such as baseline hyperuricemia, bulky tumor burden, elevated serum LDH, and elevated WBC. The objectives of the present study were to assess frequency of Tumor Lysis Syndrom in children with ALL in two methods of induction chemotherapy, aggressive and slow induction. Materials and Methods In this double blind randomized interventional study, the number of 60 ALL patients in the Shahid Sadoughi Hospital Yazd were studied. They randomly treated using two various methods 30 patients by invasive and 30 by slow induction chemotherapy. Results From 60 patients, 10 cases (16.6%) developed Tumor lysis syndrome. Seven of 10 treated by aggressive chemotherapy and remaining 3 by slow chemotherapy. No significant differences were found (PV= 0.166) between them. Conclusion Based on this study there was no significant difference between Tumor Lysis Syndrom in aggressive induction chemotherapy and slow induction, but WBC and LDH levels before treatment can predict Tumor Lysis Syndrom.}, Keywords = {ALL, Tumor Lysis Syndrome, Induction Chemotherapy}, volume = {1}, Number = {1}, pages = {19-23}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-25-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-25-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2010} } @article{ author = {Ghasemi, Ali and Hiradfar, Ataallah and Pedram, Mohamm}, title = {An Epidemiologic Study of Ewing Sarcoma Family at SHAFA Hospital in Khozestan Province-IRAN, a Referral Children Cancer Treatment Center}, abstract ={ABSTRACT Background Ewing Sarcoma is the second most frequent primary bone cancer, following Osteosarcoma in children. These tumors consist of small, round, or oval cells, which are believed to derive from parasympathetic autonomic nervous system. The common clinical presentations are pain, local tenderness, fever, palpable mass, and pathologic fractures. Methods and Materials This study describes 47 children affected by Ewing Sarcoma registered since 1991 to 2007. All data were extracted from hospital admission notes and outpatient clinical records. Results Twenty seven patients were male and 20 were female. It is slightly more common in boys. Pain, Local tenderness, fever, and Pathologic fractures were common presentation. Majority of patients were between 10-15 years old. Conclusion Local tenderness, pain, and limping are important symptoms in children that should be check-up for immediate diagnosis and also proper management.}, Keywords = {Sarcoma, Ewing, bone cancer, children}, volume = {1}, Number = {1}, pages = {24-26}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-26-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-26-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2010} } @article{ author = {Ghasemi, Nasrin and Ayatollahi, Jamshid and Zadehrahmani, M and Nasiri, A and Abedi, A and Shokraneh, S and Tahmasebi, M}, title = {Frequency of ABO and Rh Blood Groups in Middle School Students of Yazd Province}, abstract ={Abstract Objective The history of the studies on blood groups dates back to early 20th century. More than 600 antigenic structures were detected among 29 blood groups. However, ABO and Rh antigenic structures were taken into consideration in transfusion medicine. Frequency of the blood groups in a community helps the individuals in need and blood bank employees, which could be related to some disorders. Methods This study aimed to find out the frequency of ABO and Rh blood groups in middle school students of Yazd province, which was done by evaluation of 2000 students between September 2006 and March 2007. Blood groups were examined by slide test method. Place and date of birth were answered by parents. Results The frequency of the blood groups B, O, A, AB were found in order as 30.6%, 30.4%, 27%, 12% respectively. Chi square test showed that is no significant relationship between ABO blood groups and sex, place of birth and insemination season. Conclusion This study confirmed that ABO and Rh antigenic structure differs between regions and nations.}, Keywords = {ABO and Rh blood groups, antigens, Yazd province}, volume = {1}, Number = {1}, pages = {27-30}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-27-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-27-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2010} } @article{ author = {Pedram, Mohammad and Hiradfar, AtaAlah and Karimian, N}, title = {AN UNUSUAL PRESENTATION OF EXTRARENAL MALIGNANT RHABDOID TUMOR OF SOFT TISSUE: A CASE REPORT AND REVIEW OF THE LITERATURE}, abstract ={Extra renal extra cranial malignant rhobdoid tumors (MRT) are rare, frequently lethal and affect mostly children. No definite treatment has been made and the role of radiation therapy is poorly defined. This report explains a 14 year old girl with MRT in her neck soft tissue. She is alive with no evidence of disease 18 months after diagnosis. Through the experience with this case, we suggested that radiation therapy is not beneficial enough in all MRT cases and an aggressive multimodality approach should be chosen according to the stage and the state of its respectability.}, Keywords = {MALIGNANT RHABDOID TUMOR, SOFT TISSUE, RADIATION THERAPY, AGGRESSIVE MULTIMODALITY}, volume = {1}, Number = {1}, pages = {31-37}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-28-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-28-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2010} }