@article{ author = {Dorchin, M and MasoumiDehshiri, R and Soleiman, S and Manashi, M}, title = {Evaluation of neuropathy during intensive vincristine chemotherapy for non-Hodgkin\'s lymphoma and Acute Lymphoblastic Leukemia}, abstract ={Back ground: Vincristine (VCR), is a chemotherapy drug, useful in the treatment of leukemia, lymphoma and solid tumor and it is a potent neurotoxin and sensory neuropathy drug which a common behavioral toxicity of this drug. Neuropathy is common squeal of intensive chemotherapy protocols that contain vincristine and corticosteroids. Materials and Methods: This study was a retrospective and descriptive study of neuropathy during in chemotherapy program with vincristine for patients with non-Hodgkin's lymphoma (NHL) and Acute Lymphoblastic Leukemia (ALL). Data was analyzed by spss Version16 software. Results: From total of 51 cases, 23 patients had vincristine neuropathy (45%). Patients with visceral neuropathy have shown ileus, constipation in 13 patients (25%), occasionally severe diarrhea 11 (21%), mild diarrhea 7 (13.7%) and transient diarrhea in 16 patients (31%). Motor neuropathy were found in one patient with Bell, s palsy (1.9%) and one patient with Hoarseness. 12 patients (23.5%) had some type of complication together with sensory peripheral neuropathy. Conclusion: Almost half of patients with vincristin chemotherapy had neuropathy and the mean age of patients with neuropathy was 12.3 years.}, Keywords = {Vincristine; Neuropathy; Acute Lymphoblastic Leukemia; non-Hodgkin\'s lymphoma.}, volume = {3}, Number = {4}, pages = {138-142}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-141-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-141-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2013} } @article{ author = {Abrishami, F and Golshan, A}, title = {Frequency of Iron Deficiency Anemia in Girls Studying in Mashhad High Schools}, abstract ={Background Iron deficiency is one of the most prevalent anemia. 2 million people in the world suffer from it. All young girls are at higher risk for iron defiency anemia, therefore,diagnosis and prevention of this anemia in the young age is very important. Materials and Methods: A total of 1500 high school girls educated in five regions of education of Mashhad (ages 14-18 years) were studied. Cell blood count (CBC), serum iron, total iron binding capacity(TIBC),ferritin and peripheral blood smear were performed . If mean corpuscular volume (MCV) was less than normal(5×106/mm3 ), hemoglobin electrophoresis was subjected to test by methods of cellulose acetate to check the possibility of thalassemia minor.The data was analyzed by SPSS(version19) and Minitab software. Result: This is a descriptive cross sectional research. From 1500 under-experiment people,1094 cases (72.9%) were non-infected, 310 cases(20.7%) had iron deficiency anemia, and 96 cases(6.4%) had other disorders such as thalassemia. In girls with anemia, 272 cases (87.7%) were in stage I, 17 cases (5.5%) in stage II and 21 cases (6.8%) in stage III. The average age in stage I was higher than stage II and III. . Mean and standard deviation for Hb, Hct, MCV, MCH, MCHC, Fe, TIBC and Ferritin had significant difference in infected and non-infected group. Conclusion This study revealed that the prevalence of iron deficiency anemia in young girls are moderate, so that it is important to reduce the prevalence of iron deficiency anemia in young girls.}, Keywords = {Anemia; Iron deficiency; Malnutrition }, volume = {3}, Number = {4}, pages = {143-148}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-142-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-142-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2013} } @article{ author = {Shahramian, I and Noori, NM and Akhlaghi, E and Ramezani, AA and Sharafi, E}, title = {Correlation between serum leptin level and thyroid hormones in children with major beta-thalassemia}, abstract ={Background Beta-thalassemia is the most common hematology disease in human and leptin is one of the hormone that produce by adiposities cells. The purpose of this study was to investigate the relationship between serum leptin level and thyroid hormones in children with major beta-thalassemia. Materials and Methods This descriptive-cross sectional study was performed on 90 children aged 6-16 years old with beta-thalassemia. Body Mass Index (BMI ) were meuseurd in all patients and then, after collecting the samples, leptin and thyroid hormones levels of the serum were measured in the patients with thalassemia via ELISA method. Then, all data was analyzed by Pearson correlation test, and x2 statistical tests and P < 0.05 was considered as a significant difference. Results The mean of body mass index and serum leptin level in the patients group was 16.58±2.43 and 1.521 ±2. 49, respectively. The mean serum levels of thyroxin (T4), triiodothyronine (T3), and thyroid- stimulating hormone (TSH) in patient's groups were7.94 ±3.56, 1.28 ± 0.46, and 2.85 ±3. 44, respectively. There was significant correlation between serum leptin levels and T4 in patients with major thalassemia also there was no significant correlation between serum leptin level and T3and TSH. There was a significant correlation was between the leptin serum level and BMI in patients (P value=0.008). Conclusion The results of this study demonstrated that in patients with major thalassemia, there was significant correlation between serum leptin level and thyroxin hormone. Leptin level has more relationship with thyroxin than thyroid- stimulating hormone.}, Keywords = {Thalassemia; leptin; thyroid hormone; thyroid stimulating hormone}, volume = {3}, Number = {4}, pages = {149-153}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-144-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-144-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2013} } @article{ author = {Abdollahi, E and Tavasolian, F and Ghasemi, N and Vakili, M and Amini, A}, title = {The effect of parental ABO blood group on fetal surveillance}, abstract ={Background Several factors may cause infertility and fetal loss. Blood groups antigens seem to be implied in the mechanisms of infertility and fetal loss. Maternal natural antibody can react against father’s blood group antigens on spermatozoa. The effects of parental blood group system on infertility and fetal surveillance perceived by its manifestation in prezygotic (caused infertility) and postzygotic (caused fetal loss) stages. Objective of the present study is to determine the effect of parental ABO blood group on fetal surveillance and men infertility. Materials and Methods This is a retrospective, cross sectional study. Our study was carried out in fertility and infertility center of Yazd city. Blood group of 118males (group1:100 males with infertility and group 2: 18 males with abortion history in female partners) that referred to this center was evaluated based on medical document’s patients. Data were analyzed with SPSS 16 software using chi-square test. The results were considered significant when P-value was <0.05, CI: 0.95. Results Results indicated that overall distribution of blood groups in group 1 was:50%, 25%, 16% and 9% and in group 2: 56%,27%,11%,6% for blood groups O, A, B and AB respectively. There is a significant relationship between male infertility and blood group O (P value = 0.01). There is also a significant relationship between parental blood group O and fetal loss in group 2 (P value =0.03) Conclusion The present study revealed that there is a significant relationship between father’s blood group O and fetal loss, so that appropriate intervention strategies can be followed.}, Keywords = {ABO blood group system; fetal;surveillance }, volume = {3}, Number = {4}, pages = {154-158}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-145-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-145-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2013} } @article{ author = {robati, R and Farokhi, MmM}, title = {Evaluation the dentists’ awareness of inherited bleeding disorders and anticoagulants in Shiraz}, abstract ={Background Some of the dental procedures can cause bleeding. Bleeding control can be difficult in some patients because of systemic disease or chronic anticoagulant therapy, so they may be at increased risk for bleeding occurrences or even death following invasive dental procedures. This study was schemed to measure the knowledge of general dentists in Shiraz city regarding coagulation tests performed in bleeding disorders during 2011 to 2012. Materials and Methods In this descriptive-analytical study, a questionnaire (consist 23 questions) was designed with the help of specialists in the field of oral medicine and hematology. This questionnaire was distributed among 146 general practitioners. Collected information was analyzed with SPSS version 16. Results The mean mark for dentist’s knowledge was 9.40 ± 1.30 (categorized moderate level). There was no significant difference in the mean knowledge scores among male and female dentists. Tukey’s test displayed a significant difference in the mean knowledge level among 21 to 30 years old and over forty years' old dentists (p< 0.03). Conclusions This study showed that knowledge of the dentists regarding bleeding disorders is not at optimal level which needs planning for continuing education courses. Keywords:}, Keywords = {Knowledge; Blood Coagulation Tests; Blood Coagulation Disorders}, volume = {3}, Number = {4}, pages = {159-163}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-118-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-118-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2013} } @article{ author = {Naderi, M and Dorgalaleh, A and Tabibian, Sh and Alizadeh, Sh and Eshghi, P and Solaimani, Gh}, title = {Current understanding in diagnosis and management of factor XIII deficiency}, abstract ={Factor XIII or "fibrin-stabilizing factor," is a transglutaminase circulates in the blood circulation as a hetero tetramer with two catalytic A subunits and two carrier B subunits. This important coagulation factor has a crucial role in clotting cascade and produces strong covalent bonds between soluble formed fibrin monomers during coagulation. This stable cross linked fibrin strands are resistant to degradation by the fibrinolytic system that enables the body to stop potential bleeding episodes. In the absence or severe decrease of factor XIII, although the clot is formed, but is rapidly degraded by the fibrinolytic system, and delayed bleeding occurs. Factor XIII deficiency is an extremely rare bleeding disorder with estimated incidence of 1/2-3000, 000 in the general population. Presumptive diagnosis of factor XIII deficiency was by clot solubility test in 5M urea or 1% monochloroacetic acid environments. In patients with abnormal screening clot solubility test, the disease can be confirmed by more specific tests such as quantitative factor XIII activity assay and FXIIIAg assay.After diagnosis of disease all patients with severe factor XIII deficiency(<1 U/dl) should receive prophylactic substitution therapy with fresh frozen plasma (FFP) and cryoprecipitate as traditional choices or purified concentrate of blood coagulation factor XIII (Fibrogammin P) in order to control severe and life-threatening clinical complications of factor XIII deficiency.}, Keywords = {Factor XIII; Coagulation; Bleeding}, volume = {3}, Number = {4}, pages = {164-172}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-147-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-147-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2013} } @article{ author = {Binesh, F and Yousefi, A and Ordooei, M and Bagherinasab, MA}, title = {Gaucher’s Disease, an Unusual Cause of Massive Splenomegaly, a Case Report}, abstract ={Background Gaucher’s Disease (G.D.) is an autosomal recessive disorder resulting from the accumulation of glucocerebrosidase in the cells of macrophage-monocyte system as a result of a deficiency in lysosomal glucocerebrosidase. This enzyme is encoded by a gene on chromosome-1. Here we report a case of Gaucher’s Disease .G.D is rare in Yazd. Case reports We reported a patient that presented with weakness, pallor and gradually increasing abdominal girth. Clinical examination and history pointed to be a lipid storage disease. Final diagnosis of G.D. was reported after examining the bone marrow smears. Confirmation of diagnosis on Gaucher’s disease was performed by measurement of glucocerebrosidase level. Conclusion We report a case of G.D. to emphasize the importance of early recognition by clinical manifestation and histological findings. G.D. should be considered in the differential diagnosis of children with unexplained splenomegaly.}, Keywords = {Gaucher Disease; Splenomegaly; Diagnosis}, volume = {3}, Number = {4}, pages = {173-175}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-146-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-146-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2013} }