@article{ author = {Mansourabadi, A and Moogooei, M and Nozari, S}, title = {Evaluation of Distress and Stress in Cancer Patients in AMIR Oncology Hospital in Shiraz}, abstract ={Background Routine screening for distress is internationally recommended as a necessary standard for good cancer care given its high prevalence and negative consequences on quality of life. This study attempts to support validation of Distress Thermometer (DT) in Shiraz, Iran and in the second step to investigate privilege/priority of DT over other referent criterion measures. Material and methods In total, 58 outpatients with cancer were recruited from AMIR Oncology hospital in Shiraz, Iran. Each participant completed the DT and a list of 34 possible cancer-related problems (the Problem List), the Hospital Anxiety and Depression Scale (HADS), the 18-item Brief Symptom Inventory (BSI-18), and a short visual analog scale to determine the understandability of the tools. Results Characteristic analysis revealed that DT cutoff scores ≥4 and ≥5 had optimal sensitivity and specificity relative to both HADS and BSI-18 cutoff scores for general caseness and more severe psychological distress, respectively. Patients with DT scores ≥4 (cases) were more likely to be women suffering from psychological problems in the past experience stressful events in the 3 years ago and encounter more family, emotional, and physical issue related to cancer or cancer treatment (p=0.02). Conclusion Patients indicated that the DT was easier to fill out and to understand than the HADS, but not the BSI-18. The DT was identified as a simple and effective screening instrument for detecting distress in Iranian cancer patients as a first step toward more properly referring those in need to psychosocial intervention.}, Keywords = {Distress, Stress, Distress Thermometer, Brief Symptom Inventory, Hospital Anxiety and Depression Scale}, volume = {4}, Number = {4}, pages = {131-140}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-181-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-181-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2014} } @article{ author = {Alizadeh, Sh and Kaviani, S and Soleimani, M and Abroun, S and Kashani-Khatib, Z and Asgharzadeh, A and Dargahi, H and Mousavi,}, title = {Mir-55 inhibition can reduce cell proliferation and induce apoptosis in Jurkat (Acute T cell Leukemia) cell line}, abstract ={Background MicroRNAs are small and non-coding RNA molecules with approximately 22 nt in length that cause inhibition of translation or degradation of mRNA. MiR-155 is a kind of molecule with different functions, such as its role in proliferation, apoptosis, inflammation, differentiation, and immunity. One of its best known functions is apoptosis that affects on caspase-3 activity. The main aim of this study was evaluation of miR-155 inhibition effect on cell proliferation and apoptosis induction in Jurkat cells. Material and Methods In this study, Jurkat cells along with MTT assay were used for evaluation of sensitivity to varied concentrations of miR-155 inhibitor (25, 50 and 75 nmol). MiR-155 expression level was analyzed using the quantitative real-time polymerase chain reaction (QRT-PCR). Caspase-3 activity was measured by caspase-3 colorimetric activity assay kit. Unpaired t- test was applied for the analysis of MTT and apoptosis results. Probability of 5% was assumed as statistically significant. Results According to our results, the use of miR-155 inhibitor increased the activity of caspase-3 by 2 fold in 75 nmol concentration. In this research, we found that the proper increase of miR-155 inhibitor concentration can inhibit miR-155 and consequently increase caspase-3 activity and induce apoptosis in the Jurkat cells leading to cell death ultimately. Conclusions Apoptosis induction by miRNAs activation or inhibition is probably one of the best and low risk ways of cell death induction in malignancies. Due to role of miR-155 in several cancer cells, it may be used as a therapeutic target in future.}, Keywords = {miRNA, miR-155 inhibitor, Apoptosis, jurkat cells}, volume = {4}, Number = {4}, pages = {141-150}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-182-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-182-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2014} } @article{ author = {Hiradfar, AA and Banihosseinian, M}, title = {The Efficacy of Recombinant Human Erythropoietin in Treatment Chemotherapy Induced Anemia in Children Diagnosed with a Solid Cancer}, abstract ={Background Recombinant human erythropoietin (rHuEPO) treatment can increase hemoglobin levels and decrease transfusion requirements. This study aims to investigate how blood transfusion influences Hemoglobin levels in patients receiving rHuEPO for 12 weeks. Materials and Methods This was a case-control study of 60 patients less than 15 years with anemia and a solid tumor in any location between February 2013 and March 2014. Median age of the patients were 6.27±0.58 years (range, 0.9-14 years). The patients were randomly assigned in two groups of rHuEPO receiving group and control group. 29 Patients in rHuEPO group received 150 IU/kg/dose rHuEPO subcutaneously, 3 times a week, for 12 weeks. The number of patients received transfusion during the treatment period was compared in the preceding 12 weeks. Also, adverse events (AE) were recorded at the 4th, 8th, and 12th weeks. Results Mean hemoglobin levels, before and after study, in rHuEPO group were 8.85±1.01 g/dl and 9.90±0.29 g/dl, respectively (p<0.001) and in control group were, 9.00±0.09 g/dl and 7.81±0.23 g/dl, respectively (p=0.25). Among 60 patients initially eligible the present study, 57 (29 in rHuEPO group and 28 in control group) completed study course.There was a significant decrease in transfusion requirements in the rHuEPO receiving group (p=0.004). 5 (17.2%) patients in the rHuEPO group needed a blood transfusion, whereas 15 (53.6%) patients needed a transfusion in the control group. rHuEPO occasioned hypertension in one patient at 4th week that caused to end the treatment. All other AE were transient, which did not reoccur after the transient discontinuation of the medication (p<0.05). Conclusions Results showed that the rHuEPO (150 IU/kg/day, 3 times a week) was effective in increasing hemoglobin levels as well as decreasing blood transfusion requirements in children with anemia following intensive chemotherapy.}, Keywords = {Anemia, Recombinant Human Erythropoietin, Chemotherapy, Solid cancer}, volume = {4}, Number = {4}, pages = {151-159}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-183-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-183-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2014} } @article{ author = {Sharif, MR and Madani, M and Tabatabaie, F}, title = {Comparative Evaluation of Iron Deficiency among Obese and Non-obese Children}, abstract ={Background Obese children are at the risk of micronutrient deficiency especially iron deficiency. Given the importance of iron deficiency in this age group and considering the existing discrepancies, present study was performed with the aim of evaluating iron deficiency in obese children. Material and Method This study was conducted, in the form of a case-control study, on 100 children aged between 5 to 15 during June and November 2013 in Kashan. Cases consisted of 50 obese children and controls were 50 children who were not obese.Blood sample was drawn to check for serum iron, total iron binding capacity (TIBC) by biochemistry method and plasma ferritin by ELISA method. The obtained data were entered into SPSS software version 16 and statistically analyzed. P < 0.05 was identified as statistically significance. Results The mean values of serum iron were 52.38 and 64.50 microg/dL for the case and control groups (P<0.02). TIBC levels in obese and non-obese Children were 434.80 and 382.28 microg/dL (P<0.008). The ferritin level in the study group was 70.56 versus 68.06 ng/ml in the control group (P=0.79). In the obese children group, 8.3% (n=2) of children with iron deficiency had ferritin levels less than 15 while in control group 100% (n=14) of iron deficient children had ferritin levels below 15 (P<0.001). Conclusion: In our study, mean serum iron levels were lower among obese children in comparison with control group. However, ferritin concentrations were similar in both groups. It is supposed that due to inflammatory state caused by obesity, serum ferritin levels are naturally higher in obese people. It is suggested that higher levels of ferritin considered as normal reference values in obese people.}, Keywords = {Obesity, Micronutrient, Iron deficiency, Children, Ferritin}, volume = {4}, Number = {4}, pages = {160-166}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-184-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-184-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2014} } @article{ author = {Bazmamoun, H and Razavi, Z and Esfahani, H and Arefian, MS}, title = {Evaluation of Iron deficiency anemia and BMI in children suffering from Helicobacter pylori infection}, abstract ={Background Recent studies suggest an association between H. pylori infection and disorders such as iron deficiency anemia and growth delay. Considering the high prevalence of H. pylori infection and iron deficiency anemia, this study was performed in order to evaluate their relevance in children undergoing an upper endoscopy. Materials and Methods In this case-control study, children aged 2 to 16 years old, undergoing endoscopy from March 2012 to March 2013 at Besat Hospital of Hamedan, were selected. Participants were divided in H.Pylori infected and non-infected groups. Then the two groups were compared in terms of body mass index (BMI) and the incidence of iron deficiency anemia. The presence of Helicobacter pylori infection in children was confirmed by Giemsa staining of gastric biopsy specimens. Collected data was analyzed by SPSS 17.0 (SPSS Inc., Chicago, IL) and t-test and chi-square. Results In this study, 200 children (94 male and 106 female) were evaluated. The most common presenting symptom in both groups was abdominal pain. 8.2 % (9 cases) of the infected patients and 10.5% (10 cases) of the non-infected patients had iron deficiency anemia which this difference was not statistically significant (p=270). Also, no statistically significant difference was noted between the two groups in terms of gender (p=0.32), hemoglobin (p=0.35), Ferritin levels (p= 0.275) and body mass index (p= 0.273). Conclusion The results of this study not showed an association between H. pylori infection and iron deficiency anemia or body mass index in studied children}, Keywords = {Helicobacter pylori, iron deficiency anemia, body mass index, children}, volume = {4}, Number = {4}, pages = {167-171}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-185-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-185-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2014} } @article{ author = {Khojastepour, L and Zareifar, S and Ebrahimi, M}, title = {Dental Anomalies and Dental Age Assessment in Treated Children with Acute Lymphoblastic Leukemia}, abstract ={Background This cross sectional study was performed to evaluate dental ages and incidence of dental anomalies in children treated for acute lymphoblastic leukemia (ALL). Methods and materials A total of 25 ALL patient who passed at least 2 years of chemotherapy and 25 healthy sex and age matched children were evaluated. Dental age as well as dental anomalies in shape, size, number, and structure was recorded based on their panoramic radiographies which were taken for dental purposes. Results The number of dental anomalies significantly increased in ALL treated children. Seven ALL cases (28%) in compression to only one (4%) in control group had at least one dental anomaly. However, there was neither statistically significant differences between the mean of dental (p=0.32) and chronologic age (p=0.12) in both groups, nor between dental age of cases and control group (p=0.62).The age at the onset of treatment as well as treatment durations has not affected dental age and the incidence of dental anomalies significantly (p<0.05). Conclusion Chemotherapy in children results in emergence of dental anomaly. Dental age, maturity, and development process however seems to be independent from chemotherapy.}, Keywords = {Acute Lymphoblastic Leukemia, Dental anomalies, Dental age, Chemotherapy}, volume = {4}, Number = {4}, pages = {172-177}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-186-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-186-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2014} } @article{ author = {Mansouri, N and Movafagh, A and Sayad, A and Ghafouri-Fard, S and Darvish, H and Zare-Abdollahi, D and Emamalizadeh, B and Shahvaisizadeh, F and Ghaedi, H and Bastami, M}, title = {Hepatitis B Virus Infection in Patients with Blood Disorders: A Concise Review in Pediatric Study}, abstract ={Childhood Hepatitis B virus (HBV) infection causes both medical and public health challenges. Infants who acquire HBV parentally have up to 90% risk of developing chronic HBV infection. It is now estimated that approximately 10% of worldwide cancers are attributable to viral infection, with the vast majority (>85 %) occurring in the developing world. In this distribution, elevated rate and prevalence of HBV marker have been found in patients with malignancies as compared to the general population. By reviewing the web-based search for all Persian and English types of scientific peer review published articles initiated using Iran Medex, MEDLINE/PubMed, CINAHL and other pertinent references on websites about HBV and HCV blood disorders. The high prevalence of HBV and HCV infective markers was detected in patients with different malignancies. Moreover, identification of high prevalence of HBV infective markers in leukemia patients proposed strong association between hepatitis viral infections and leukemia.}, Keywords = {Malignancy, Heterogeneous population, HBV, HCV, Pediatric}, volume = {4}, Number = {4}, pages = {178-187}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-187-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-187-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2014} } @article{ author = {Masoumi-Dehshiri, R and Hashemi, AS and Neamatzadeh, H and Zare-Zardini, H}, title = {A Case Report: Acute Myeloid Leukemia (FAB M7)}, abstract ={Acute myeloid leukemia (AML-M7) is a type of pediatric AML accounting for 3–10% of primary childhood AML and children may present with a broad variety of symptoms including low-grade fever, diarrhea, easy bruising, failure to gain weight and life-threatening conditions. We report a rare case of AML .A 26-month-old boy who presented with weakness and fatigue. He was diagnosed as a case of AMLM-7 on the basis of peripheral blood finding, bone marrow examination report and immune phenotyping.}, Keywords = {acute myeloid leukemia, bone marrow examination, weakness}, volume = {4}, Number = {4}, pages = {188-190}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-188-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-188-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2014} }