@article{ author = {Ansari, Sh and Shirzadi, E and Elahi, M}, title = {The Prevalence of fungal infections in children with hematologic malignancy in Ali-Asghar Children Hospital between2005 and 2010}, abstract ={Background A fungal infection represents a growing problem in children with hematologic malignancies,during chemotherapy induced neutropenia.Fungal colonization is considered a major riskfactor for subsequent fungal infections. The aim of this retrospective study was to evaluate prevalence of fungal infection among children admitted to hospital between 2005 and 2010 in Tehran, Iran. Materials and Methods 617 hematological patients in the age range of neoteric to 19 years old were enrolled and 87 cases with invasive fungal infections were extracted from patients' files and documented. Diagnosis of fungal infections was based on the blood culture, urine culture and clinical examination for candidasis and galactomannan for aspergillus. Results the mean age of cancer diagnosis was 6.33 years old and the mean age of fungal infection was 7.95 years old. The majority of the infections was caused by candidia spp (74.7%), followed by aspergillus spp (17.2%) and zygomycetes (11.5%). Among candidiasis patients, oral infection had the highest manifestation (92.3%) whereas in 10 of 15 patients with aspergillus, the infectious site was the lung. There was a significant association between mortality and the type of fungal infection (p <0.0001). Conclusion Our finding suggests that there is a high rate of fungal infections in children receiving remission therapy for onco-hematology. These results help improve the management of these patients, however Further studies are needed.}, Keywords = {Candidiasis, Aspergillosis, Mucormycosis, Hematologic malignancy, Children}, volume = {5}, Number = {1}, pages = {1-10}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, url = {http://ijpho.ssu.ac.ir/article-1-190-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-190-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Shahramian, I and Noori, NM and Teimouri, A and Akhlaghi, E and Sharafi, E}, title = {The Correlation between Serum Level of Leptin and Troponin in}, abstract ={Background Polypeptide hormone Leptin suppresses inflammation in the heart muscle and protects heart from diseases. The purpose of this study is to evaluate the relationship between leptin and troponin serum levels with cardiac involvement in patients with major beta thalassemia. Materials and Methods In this cross-sectional study, 70 children with major thalassemia were selected. Two ml blood was taken as sample from all children and after separating serum the samples were maintained in -20°C temperature. Then, regarding cold chain conditions, the sample were sent to the Biochemistry Lab. Afterwards, leptin and troponin serum levels with the relevant kits and BMI were measured in all children, and information about age and gender was recorded. Collected data were analyzed with SPSS. Results The mean of leptin in girls and boys were 2.47 ± 3.13 and 0.96 ± 1.08 respectively which showed a significant difference (t=2.74, p =0.009). A significant correlation was also observed between BMI and leptin (r = 0.374, P = 0.002). Another significant association was found between leptin and age (r = 0.248, P = 0.041). However, a significant inverse correlation between serum ferritin and age (r = - 0.607, P = 0.0001) was discovered. No correlation was found between leptin, troponin, and ferritin. Conclusion Since Leptin increases with the advent of cardiac involvement and independent from troponin T, it can be a predictive marker of cardiac involvement in patients with major beta thalassemia.}, Keywords = {Leptin, Major beta thalassemia, Troponin}, volume = {5}, Number = {1}, pages = {11-17}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, url = {http://ijpho.ssu.ac.ir/article-1-191-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-191-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Ahmadi, M and Jahani, S and Tabesh, H and Poormansouri, S and Shariati, A}, title = {The Effectiveness of self management program on quality of life in patients with sickle cell disease}, abstract ={Background Sickle cell patients suffer from many physical, psychological, and social problems that can affect their quality of life. To deal with this chronic condition and manage their disease and prevent complications associated with the disease, they must learn skills and behaviours. The aim of this study was to determine the effectiveness of self-management programs on quality of life in these patients. Material and Methods Samples of this quasi-experimental study, which included 69 patients with sickle cell disease referring to the Thalassemia Clinic of Shafa Hospital, were entered into the study by census method. Patients received a self-management program using the 5A model for 12 weeks, while their quality of life before the intervention were assessed at the twelfth week and thirty-sixth week using SF-36 questionnaire. Data were analyzed by descriptive statistics, paired t-test, Wilcoxon test, Hotelling's T2, and repeated measures test. Results The eight dimensions and the total QoL score after intervention were significantly increased compared to those before the intervention (P<0.001). Repeated measures test showed that the mean score of eight QoL dimensions and the total QoL score decreased in the thirty-sixth week, compared to twelfth week. However, it was significantly enhanced in comparison with the intervention baseline (P<0.05). Conclusions Current study revealed the efficacy of self-management interventions on the quality of life in patients with sickle cell disease. Therefore, application of this supportive method could be useful to empower the patients and help them to manage the disease.}, Keywords = {Self-management, Quality of life, sickle cell}, volume = {5}, Number = {1}, pages = {18-26}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, url = {http://ijpho.ssu.ac.ir/article-1-192-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-192-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Sakhinia, E and Estiar, MA and Andalib, S and Rezamand, A}, title = {Expression Profiling of Microarray Gene Signatures in Acute and Chronic Myeloid Leukaemia in Human Bone Marrow}, abstract ={Background Classification of cancer subtypes by means of microarray signatures is becoming increasingly difficult to ignore as a potential to transform pathological diagnosis nonetheless, measurement of Indicator genes in routine practice appears to be arduous. In a preceding published study, we utilized real-time PCR measurement of Indicator genes in acute lymphoid leukaemia (ALL) and acute myeloid leukaemia (AML) as a way of application of microarray gene signatures. More to the point, the specificity of such genes for this distinction was investigated by their measurement in cases afflicted with chronic myeloid leukaemia (CML) and with normal bone marrow (BM). Material and Method Mononuclear cells were sorted into unselected (total), CD34+ve, and CD34-ve fractions, mRNA globally amplified by using PolyA PCR. Moreover, the level of expression of 17 Indicator genes was identified by using real-time PCR. Results No statistically significant difference was observed in expression for any gene among CML cases. Cyclin D3 (p≤0.04) was exclusively upregulated in CML in the CD34+ fraction, notwithstanding upregulation of HkrT-1 (p≤0.02) and fumarylacetoacetate (p≤0.03) in AML. HOXA9 experienced a non-significant upregulation in AML however, in combination with proteoglycan 1 distinguished between AML and normal samples in the CD34- fraction in unsupervised clustering. Unsupervised clustering distinguished among AML and the other diagnostic groups. Conclusion The evidence from the present study suggests that the genes discriminatory between ALL and AML are uninformative in the context of CML and normal BM, excepting for distinction with AML.}, Keywords = {Microarray, PolyA PCR, RT-PCR, Gene Signature, Myeloid Leukaemia }, volume = {5}, Number = {1}, pages = {27-42}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, url = {http://ijpho.ssu.ac.ir/article-1-193-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-193-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Ghotaslou, A and Nadali, F and Ghasemi, A and Chahardouli, B and Abbasian, S and Rostami, S}, title = {Low Frequency of C-MPL Gene Mutations in Iranian Patients with Philadelphia-Negative Myeloproliferative Disorders}, abstract ={Background Myeloproliferative disorders are a group of diseases characterized by increased proliferation of myeloid lineage. In addition to JAK2V617F mutation, several mutations in the c-MPL gene were described in patients with Philadelphia-negative chronic myeloproliferative disorders that could be important in the pathogenesis of diseases. The aim of present study was to investigate the frequency of c-MPL and JAK2V617F mutations in Iranian patients with Philadelphia-negative myeloproliferative disorders. Material and Methods Peripheral blood samples from 60 patients with Philadelphia-negative MPD) subgroups ET and PMF) and 25 healthy subjects as control were collected in order to investigate the mutation status of c-MPL and Jak2V617F by using Amplification-Refractory Mutation System (ARMS) and Allele-Specific PCR (AS-PCR), respectively and results were confirmed by sequencing. Results Among the total 60 patients studied, 34 (56.6%) and 1(1.7%) had Jak2V617F and c-MPL mutation, respectively. Patients with Jak2V617F mutation had higher WBC counts and hemoglobin concentration than those without the mutation (p= 0.005, p=0.003). In addition for all healthy subjects in control group, mutation was negative. Conclusions The present study revealed that the c-MPL mutations unlike the Jak2V617F mutations were rare in Iranian patients with Ph-negative MPNs and the low mutation rate should be considered in the design of screening strategies of MPD patients.}, Keywords = {ARMS –PCR, c- MPL mutation, JAK2V617F, Myeloproliferative Disorders}, volume = {5}, Number = {1}, pages = {43-51}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, url = {http://ijpho.ssu.ac.ir/article-1-194-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-194-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Gheibi, Sh and Farrokh-Eslamlou, HR and Noroozi, M and Pakniyat, A}, title = {Refractory iron deficiency anemia and Helicobacter Pylori Infection in pediatrics: A review}, abstract ={Background Since the discovery of Helicobacter pylori, several clinical reports have demonstrated that H. Pylori infection has emerged as a new cause of refractory iron stores in children. We carried out a systematic literature review to primarily evaluate the existing evidence on the association between childhood H. Pylori infection and iron deficiency anemia (IDA) and secondly, to investigate the beneficial effects of bacterium elimination. Material and Methods This review concerns important pediatric studies published from January 1991 to October 2014. Fourteen case reports and series of cases, 24 observational epidemiologic studies, seven uncontrolled trials, and 16 randomized clinical trials were included in the review. Results Although there are a few observational epidemiologic studies and some randomized trials mostly due to the potential confounders, most studies reported a positive association linking between H. Pylori infection and iron deficiency or iron deficiency anemia among children. In addition, it seems that elimination of H. Pylori infection induces beneficial effects on iron deficiency. Conclusions Since the evidence for the association of H. pylori eradication therapy and refractory childhood IDA is not enough and there are contrasting data about such association, future high quality and cohort researches are needed to determine the causal association.}, Keywords = {Iron deficiency anemia, Helicobacter Pylori Infection, pediatrics}, volume = {5}, Number = {1}, pages = {50-64}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, url = {http://ijpho.ssu.ac.ir/article-1-195-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-195-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Farhangi, H and Sharifi, N and Ahanchian, H and Izanloo, A}, title = {Autoimmune Hemolytic Anemia preceding the Diagnosis of Primary Central Nervous System Lymphoma}, abstract ={In this study, a 2.5-year-old boy suffering from a febrile seizure with normal laboratory tests and a history of immune hemolytic anemia was examined. Brain MRI demonstrated some tumors in the frontal, parietal, and occipital lobe that corroborated the pathology results of primary central nervous system lymphoma for the patient. The patient was treated with high- dose of Methotrexate. Our result suggested regular and careful monitoring of patients with autoimmune hemolytic anemia in order to control the manifestations of concomitant disease such as lymphoma that may develop later}, Keywords = {Anemia, Lymphoma, Nervous System, MRI}, volume = {5}, Number = {1}, pages = {65-69}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, url = {http://ijpho.ssu.ac.ir/article-1-196-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-196-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} }