@article{ author = {Mirmohammadi, Seyed Jalil and Hashemi, Azam sadat and Souzani, Azadah and Dehghani, khadijeh and Atefi, Atef and ZareianYazdi, Zahr}, title = {Environmental Risk Factors for Acute Leukemia and Non-Hodgkin Lymphoma in Children}, abstract ={Abstract Objective The incidence of childhood cancer has been increasing nearly one percent per year for the past two decades. Leukemia and lymphoma are the most common types of childhood cancers. This study assessed the relation between environmental factors (Hydrocarbon, agricultural toxin, insecticide) and leukemia/lymphoma in children, which was evaluated by the frequency of the parents’ hazardous occupations, and their smoking, drug addiction, and alcoholism habits. Methods This was a case-control study on 86 children with leukemia and non-Hodgkin's lymphoma and 188 healthy controls from March 2007 till March 2010. They were matched in age and sex. Information was gathered via a questionnaire and analyzed by SPSS 15. Result There were 32 (37.2%) girls and 54 (62.8%) boys in the case group and the majority were 3-5 years old. In case group fathers’ occupations were mostly farmers 50 (58.1%), followed by painter or exposed to hydrocarbons 14 (16.6%), but in the control group, farmers were 17 (19.7%), and painters or those exposed to hydrocarbons were 5 (5.8%). The frequency of fathers' various occupations was significantly different between cases and controls. In addition, smoking, drug addiction and alcoholism was significantly higher in cases fathers than controls fathers. Conclusion The frequency of leukemia and non-Hodgkin's lymphoma in children whose father were painters, exposed to hydrocarbons and farmers are higher than normal children. So people with these occupations should pay more attention and should be protected against these risk factors. The history of addiction and alcoholism was higher in their father.}, Keywords = {Acute Leukemia, Non-Hodgkin Lymphoma, Environmental Factor}, volume = {1}, Number = {1}, pages = {1-3}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-21-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-21-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2010} } @article{ author = {Shahvazian, Najme and Hashemi, Azam sadat and Shakiba, Mehrdad and Farahzadi, Mohammad Hosein and Mahmoodabadi, Fatemeh}, title = {Efficacy of Chicory in Decreasing Serum Ferritin and Liver Enzymes in Major Beta Thalassemia Patients}, abstract ={Abstract Objective Thalassemia major is a severe transfusion-dependent anemia that needs iron chalation therapy to remove iron overload. The objectives of the present study were to assess the iron overload liver response to inulin of chicory supplementation by evaluating the serum ferritin and liver enzymes. Methods Among 70 beta thalassemia patients, 50 were selected for chelating therapy using inulin of chicory. The initial dose was 1gr given twice a day. Twenty patients were excluded because of Hepatitis B and C and cardiac heart failure. Results From 50 patients, 47 patients tolerated chicory, which the majority showed dramatic responses. Mean serum ferritin level decreased from 3563.09 ng/ml to 1728.54 ng/ml. Mean serum AST level decreased from 25.44 u/lit to 22.25 u/lit. Mean serum ALT level decreased from 30 .861u/lit to 25.085u/iit. Serum ferritin level decreased significantly after treatment (PV≈ 0.00), but there was no significant difference in AST (PV=0.379) and Alt (0.367) after chicory treatment. Conclusion The present results suggest that chicory can reduce iron over load and liver enzymes. Significant differences in serum ferritin were found during intervention, but not in LFT enzymes.}, Keywords = {Major beta thalassemia, Chicory, Ferritin, Liver enzymes}, volume = {1}, Number = {1}, pages = {4-7}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-22-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-22-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2010} } @article{ author = {Hashemi, azam Sadat and Najafi, Neda and Behnaz, Fatemeh and Zare, Asghar}, title = {Oral Ciprofloxacin Compared with Intravenous Ceftazidim on Low Risk Febrile Neutropenia in Acute Lymphocytic Leukemia}, abstract ={Abstract Objective Fever and neutropenia are a common complication of chemotherapy in cancer. It is usually managed by hospitalization and empiric administration of antibiotics. Use of Fluroquinolones is limited because of joint/cartilage toxicity. This study attempted to compare the efficacy of oral ciprofloxacin with intravenous ceftazidim in low risk febrile neutropenic lymphocytic leukemia. Methods Ninety two episodes of febrile neutropenia in 72 patients under 14 years old were studied prospectively for two years. All the patients received G-CSF plus intravenous ceftazidim 100 mg/kg/d and amikacin 15 mg/kg/d for 24 hours. These episodes randomly allocated into two groups. Group A received IV ceftazidim and amikacin for at least 3 days. After discharge they got oral cefixim 8 mg/kg daily. Group B discharged and received oral ciprofloxacin (20 mg/kg.day) for seven days. Failure was defined as temperature higher than 38 °C for more than 72 hours or major complication. Results Failure of intravenous ceftazidim plus amikasin for at least 4 days in hospital, in low risk febrile neutropenic children, was 6.5%, but failure of oral ciprofloxacin for 7 days after 24h intravenous ceftazidim plus amikasin was 4.3%. There was no arthrotoxicity in patients received ciprofloxacin. Conclusion Empirical therapy with oral ciprofloxacin is safe and effective in children with leukemia and low risk FN.}, Keywords = {Ciprofloxacin, Neutropenia, Acute Lymphocytic Leukemia}, volume = {1}, Number = {1}, pages = {8-13}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-23-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-23-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2010} } @article{ author = {Keikhaei, Bij}, title = {Sequential Deferoxamine - Deferasirox in Treatment of Major Thalassemia with Iron Overload}, abstract ={Abstract Background Iron overload is a major problem in patients with major thalassemia. An effective and safe iron chelator protocol with high compliance rate plays an important role in treatment of these patients. This study was done to assess the efficacy and safety of the sequential deferoxamine and deferasirox protocol in major thalassemia patients in Khuzestan province, Iran. Material and Method Sixty two patients were studied aged between 2 to 30 years old. A regimen consisted of 4 days deferasirox followed by 3 days deferoxamine. The duration of trial was 6 months. The efficacy was determined by comparison of ferritin level before and after treatment. Results Serum ferritin changed from 3590 ng/ml to 2563 ng /ml, which decreased significantly. During study 21% of patients experienced at least one side effect. Conclusion This is a new regimen with high efficacy, low toxicity and acceptable compliance.}, Keywords = {Sequential, Deferoxamine, Deferasirox, Major thalassemia.}, volume = {1}, Number = {1}, pages = {14-18}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-24-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-24-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2010} } @article{ author = {Hashemi, Azam Sadat and Shahvazian, Najme and Zarezade, Asghar and Shakiba, Mehrdad and Atefi, Atef}, title = {Frequency of Tumor Lysis Syndrome in Aggressive and Slow Introduction Chemotherapy in Children with ALL}, abstract ={Abstract Background Tumor Lysis Syndrome (TLS) is an oncologic emergency that results from massive lysis of malignant cells. The incidence of TLS depends on the risk factors, such as baseline hyperuricemia, bulky tumor burden, elevated serum LDH, and elevated WBC. The objectives of the present study were to assess frequency of Tumor Lysis Syndrom in children with ALL in two methods of induction chemotherapy, aggressive and slow induction. Materials and Methods In this double blind randomized interventional study, the number of 60 ALL patients in the Shahid Sadoughi Hospital Yazd were studied. They randomly treated using two various methods 30 patients by invasive and 30 by slow induction chemotherapy. Results From 60 patients, 10 cases (16.6%) developed Tumor lysis syndrome. Seven of 10 treated by aggressive chemotherapy and remaining 3 by slow chemotherapy. No significant differences were found (PV= 0.166) between them. Conclusion Based on this study there was no significant difference between Tumor Lysis Syndrom in aggressive induction chemotherapy and slow induction, but WBC and LDH levels before treatment can predict Tumor Lysis Syndrom.}, Keywords = {ALL, Tumor Lysis Syndrome, Induction Chemotherapy}, volume = {1}, Number = {1}, pages = {19-23}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-25-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-25-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2010} } @article{ author = {Ghasemi, Ali and Hiradfar, Ataallah and Pedram, Mohamm}, title = {An Epidemiologic Study of Ewing Sarcoma Family at SHAFA Hospital in Khozestan Province-IRAN, a Referral Children Cancer Treatment Center}, abstract ={ABSTRACT Background Ewing Sarcoma is the second most frequent primary bone cancer, following Osteosarcoma in children. These tumors consist of small, round, or oval cells, which are believed to derive from parasympathetic autonomic nervous system. The common clinical presentations are pain, local tenderness, fever, palpable mass, and pathologic fractures. Methods and Materials This study describes 47 children affected by Ewing Sarcoma registered since 1991 to 2007. All data were extracted from hospital admission notes and outpatient clinical records. Results Twenty seven patients were male and 20 were female. It is slightly more common in boys. Pain, Local tenderness, fever, and Pathologic fractures were common presentation. Majority of patients were between 10-15 years old. Conclusion Local tenderness, pain, and limping are important symptoms in children that should be check-up for immediate diagnosis and also proper management.}, Keywords = {Sarcoma, Ewing, bone cancer, children}, volume = {1}, Number = {1}, pages = {24-26}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-26-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-26-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2010} } @article{ author = {Ghasemi, Nasrin and Ayatollahi, Jamshid and Zadehrahmani, M and Nasiri, A and Abedi, A and Shokraneh, S and Tahmasebi, M}, title = {Frequency of ABO and Rh Blood Groups in Middle School Students of Yazd Province}, abstract ={Abstract Objective The history of the studies on blood groups dates back to early 20th century. More than 600 antigenic structures were detected among 29 blood groups. However, ABO and Rh antigenic structures were taken into consideration in transfusion medicine. Frequency of the blood groups in a community helps the individuals in need and blood bank employees, which could be related to some disorders. Methods This study aimed to find out the frequency of ABO and Rh blood groups in middle school students of Yazd province, which was done by evaluation of 2000 students between September 2006 and March 2007. Blood groups were examined by slide test method. Place and date of birth were answered by parents. Results The frequency of the blood groups B, O, A, AB were found in order as 30.6%, 30.4%, 27%, 12% respectively. Chi square test showed that is no significant relationship between ABO blood groups and sex, place of birth and insemination season. Conclusion This study confirmed that ABO and Rh antigenic structure differs between regions and nations.}, Keywords = {ABO and Rh blood groups, antigens, Yazd province}, volume = {1}, Number = {1}, pages = {27-30}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-27-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-27-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2010} } @article{ author = {Pedram, Mohammad and Hiradfar, AtaAlah and Karimian, N}, title = {AN UNUSUAL PRESENTATION OF EXTRARENAL MALIGNANT RHABDOID TUMOR OF SOFT TISSUE: A CASE REPORT AND REVIEW OF THE LITERATURE}, abstract ={Extra renal extra cranial malignant rhobdoid tumors (MRT) are rare, frequently lethal and affect mostly children. No definite treatment has been made and the role of radiation therapy is poorly defined. This report explains a 14 year old girl with MRT in her neck soft tissue. She is alive with no evidence of disease 18 months after diagnosis. Through the experience with this case, we suggested that radiation therapy is not beneficial enough in all MRT cases and an aggressive multimodality approach should be chosen according to the stage and the state of its respectability.}, Keywords = {MALIGNANT RHABDOID TUMOR, SOFT TISSUE, RADIATION THERAPY, AGGRESSIVE MULTIMODALITY}, volume = {1}, Number = {1}, pages = {31-37}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-28-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-28-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2010} } @article{ author = {Karimzadeh, P and Ghaffari, SH and Chahardouli, B and Zaghal, A and Einollahi, N and Mousavi, SA and Bahar, B and Dargahi, H and Alimoghaddam, K and Ghavamzadeh, A}, title = {Evaluation of JAK2V617F mutation prevalence in myeloproliferative neoplasm by AS-RT-PCR}, abstract ={Abstract Objective JAK2 is a non-receptor tyrosine kinase that plays a major role in myeloid disorders. JAK2V617F mutation is characterized by a G to T transverse at nucleotide 1849 in exon 12 of the JAK2 gene, located on the chromosome 9p, leading to a substitution of valine to phenylalanine at amino acid position 617 in the JAK2 protein. Methods In this study we evaluated RNA from 89 patients with MPNs and statistical analysis done with Mann-Whitney test. The mutation detected by allele specific-PCR(AS-PCR). In addition, 3 samples were sequenced in Millegen company. Results Using AS-PCR method 26/30 polycythemia vera patients (86%), 8/13 IMF patients (61%), 8/15 ET patients (53%) and none of 31 CML patients were positive for JAK2 V617F mutation. Polycythemia vera patient carrying the mutation displayed higher levels of WBC (p=0.03). Sixteen of 26 JAK2V617F positive patients were female that demonstrate correlation between the presence of a mutant allele and sex. The differences in other groups were not significant. Conclusion We have shown that a single acquired point mutation in JAK2 is present in virtually most patients with PV and in about half of those with either ET or IMF.However in other study the JAK2V617F mutation has been detected in the vast majority of patients with polycythmia vera (65-95%). It was less frequent in patients with essential thrombocythemia (23-57%), idiopathic myelofibrosis (23-57%) and chronic myeloid leukemia 19% (3/16 CML Ph-) Detection of the mutation is helpful in differential diagnosis, prognosis, and prediction of therapeutic response.}, Keywords = {JAK2 mutation, AS-RT-PCR, polycythemia vera, essential thrombocythemia, primary myelofibrosis}, volume = {1}, Number = {2}, pages = {38-42}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-30-en.html}, eprint = {}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2011} } @article{ author = {Hashemi, Azam Sadat and Souzani, Azadah and Meshkani, M and Osia, S and Shahvazian, N and Keshavarzi, S and Atefi, A}, title = {Efficacy of L-carnitine on liver function in childrens under chemotherapy with acute lymphoblastic leukemia}, abstract ={Abstract Background Patients who are to receive chemotherapy require careful assessment of liver function prior to treatment to determine which drugs may not be appropriate, and which drug doses should be modified. Following therapy abnormalities of liver function tests may be due to the therapy rather than to progressive disease, and this distinction is of critical importance. Toxicity such as hepatotoxicity could be reduced by L-Carnitine (L.C) with out affecting its anti-cancer therapeutic efficacy. The objectives of the present study were to assess the role of L-Carnitine by evaluating the liver functions. Materials and Methods We performed randomized, double-blind, placebo-controlled study, the number of 64 ALL patients were enrolled in our study. Patients was randomly divided into two groups (each group 32 patients), and using double-blind administration, group A was treated with L-Carnitine and group B with placebo for 90 days. Results We observed differences in serum AST level 3,7,30 days after chemotherapy (p=0.006, p<0.001, p= 0.001), serum ALT level 7,30 days after chemotherapy (p=0.009, p<0.001), serum ALK-P level after 30,90 days after chemotherapy (p<0.001), Prothrombin time 3,7,30 days after chemotherapy (p=0.017, p=0.010, p=0.012).No significant differences were observed in Alb and GGT in either group of patients treated with L-Carnitin or placebo. Conclusion The benefits of L-Carnitine in comparison with placebo are demonstrated in reduction serum AST, ALT, ALK-P and PT but not in Alb and GGT. These issues deserved to evaluate the value of L-Carnitine in ALL patients.}, Keywords = {ALL, L-Carnitine, LFT, Liver function}, volume = {1}, Number = {2}, pages = {43-47}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-31-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-31-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2011} } @article{ author = {Ansari, F and Soltanmohammadi, N and Naderi, G and SadeghSabet, M and Karimi, A}, title = {Study of garlic effect on fibrinolytic activity of the blood clot in vitro}, abstract ={Abstract Introduction The main function of the fibrinolytic system is to dissolve fibrin clots in circulation. This system is composed of inactive precursor plasminogen which can be converted into plasmin by the proteolytic enzymes like tissue-type plasminogen activator (tPA). Fibrinolytic properties can be found in a variety of medicine plants and they could effectively prevent cardiovascular diseases (CVD). One of these medicine plants is Allium sativum, which was used for its antiplatlet and fibrinolytic effects in patients with CVD (garlic). This study considers to find the fibrinolytic effect of the various concentration of garlic extract and the time of the most effect. Methods Garlic extracts were prepared using 70% ethanol, and labeling fibrinogen with fluorescent agent to create a labeled clot. Then 10, 25 and 50μg/μl of garlic extract were separately added to plasma environment and finally the labeled clots were inserted. At the end fluorescence intensity of the supernatant was measured. The data were analyzed using SPSS (version 16). Results The results indicated that garlic extract showed fibrinolytic effect significantly compared with the control group (p<0.05). Various concentrations of garlic extract showed significant different rise in the fibrinolytic activity of blood clot in different time (p<0.05). Desirable result obtained in the lower concentration of (10μg/μl) after 7 hours. Conclusion Garlic extract displayed the fibrinolytic activity which concentration and time factors of exposure influenced it but the minimum concentration and the maximum time showed the best result.}, Keywords = {Fibrinolytic, Allium sativum (garlic), Hydro-ethanol, Extract}, volume = {1}, Number = {2}, pages = {48-52}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-32-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-32-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2011} } @article{ author = {Hashemi, Azam Sadat and Ordooei, Mahtab and Golestan, Motahare and AkhavanGhalibaf, Mahvash and Mahmoudabadi, Fateme and Arefinia, M and Amanat, M and Purshamsi, F and Afkhami, Mohamm}, title = {Hypothyroidism and Serum Ferritin Level in Patients with Major ß Thalassemia}, abstract ={Abstract Introduction Major ß Thalassemia represents a group of recessively inherited hemoglobin disorder, which is characterized by reduced synthesis of globins chains. Frequent blood transfusions can lead to iron overload, which may result in several endocrine complication especially in the absence of adequate chelating therapy. The objective of this study were to determine the prevalence of hypothyroidism in transfusion dependent thalassemia patients treated in the hematology unit of Shahid Sadoughy hospital and determination of the correlation of hypothyroidism with the Ferritin level. Methods This study was cross-sectional study which was performed during one year. Sixty five patients, ages between 1.2 years to 27years old entered to this study (47.6%female and 52.4%male) For all of the patients T3-T4-T3RUP, TSH and ferritin level were tested. Results The mean age of the patients was 10.3 years (47.6% above 10years and 52.4% under 10years old). This study demonstrated that fourteen patients (21%) had hypothyroidism (1.5%overt low T4 and high TSH), which 7.6% was sub clinical (normal T4and high TSH and 12.3% secondary hypothyroidism) in other study prevalence hypothyroidism was 2.2%-16.5%. There was no correlation between hypothyroidism and serum ferritin level (P-value= 0.38) Conclusion The high rate of hypothyroidism indicates the importance of regular follow up of thalassemia patients to prevent complications.}, Keywords = { Hypothyroidism, Ferritin, Major ß Thalassemia}, volume = {1}, Number = {2}, pages = {53-56}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-33-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-33-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2011} } @article{ author = {Ayatollahi, Jamshid and Modaresmosadegh, M and Halvani, A}, title = {Effect of Glucantime on blood factors in patients with cutaneous leishmaniasis}, abstract ={Abstract Background Glucantime is the first line agent for treatment of cutaneous leishmaniasis (CL). It has adverse effects on blood elements. This research has been done to evaluate the blood complications of this medicine in patients with cutaneous leishmaniasis. Methods This clinical trial was done at Nikpour clinic, Yazd, Iran. Blood samples were collected from patients diagnosed with CL before treatment and after receiving 20 mg/kg intramuscular glucantime. Injection every day for 20 days. Full cell blood count was done for all patients. Statistical analysis of data was achieved by paired-T-test using SPSS software (version 13). Results The blood tests results showed glucantime significantly decreased RBC, PLT, WBC (except monocytes), Hb and Hct (P< 0.05). MCH and PMN decreased but not significantly. MCV, MCHC and eosinophil count increased but not significantly. No correlation was seen between laboratory test results and patients' age and sex. Conclusion Glucantime affected the blood indices and it was suggested to use other alternating therapy. Future study with bigger sample size should be done for the more clear results. Keywords Glucantime, Cutaneous leishmaniasis, Blood}, Keywords = { Glucantime, Cutaneous leishmaniasis, Blood}, volume = {1}, Number = {2}, pages = {57-61}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-34-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-34-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2011} } @article{ author = {Ghasemi, Nasrin and Sheikhha, Mohammad hasan and Davar, Robab and Soleimanian, Saeede}, title = {ABO Bloods group incompatibility in recurrent abortion}, abstract ={Abstract Background A vast variety of factors may cause recurrent pregnancy loss. Blood group incompatibility of parents could cause abortion. The examination of couples or twins, blood groups showed that the blood group incompatibility can affect adversely the outcome of pregnancy. Couples with blood group incompatibility are more involved in spontaneous miscarriage. Antigenes in two different blood groups could disorganize implantation. Aborted embryos with normal karyotype showed more frequently blood group incompatibility with their mother. Abnormal newborn and stillbirth were observed more frequent in couples with incompatible blood groups than without. Methods This study investigates relationship between blood groups incompatibility and recurrent miscarriage in couples who were referred to genetic counseling clinic of Yazd Research & Clinical Center for Infertility. The blood group of 100 couples with recurrent miscarriage was evaluated using slide test method. Their abortions were unknown after possible evaluation. One hundred and twelve fertile couples entered to this study as control group, which have at least two normal children without any abortion. Results The results showed blood group incompatibility was more frequent in couples with recurrent abortion than fertile couples. Conclusion Blood group incompatibility of parents could causes antigen-antibody interaction between mother and fetus, which ended with abortion. In previous study it was believed that blood group incompatibility cases fetal anemia and stillbirth.}, Keywords = { Blood groups incompatibility, Recurrent miscarriage, Antigen-antibody}, volume = {1}, Number = {2}, pages = {62-66}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-35-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-35-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2011} } @article{ author = {Azarpeikan, SAR and Hashemi, Azam Sadat and Atefi, Atef}, title = {Lacunar infarction in child with Protein S deficiency: a case report}, abstract ={Abstract Arterial ischemic stroke defines as a new focal neurologic deficit that lasted 24 hours or longer. Stroke is relatively rare in children and incidence of cerebrovascular disease is 1 per 4000 in neonates and 1 per 7000 to 1 per 70000 in older children (1 month to 18 years). Protein S deficiency is one of the causes of the stroke in children. Major manifestations of protein S deficiency are deep venous thrombosis, superficial thrombophlebitis, and pulmonary emboli. The pathogenesis of vascular occlusion in patients with protein S deficiency is unknown. The prevalence of protein S deficiency is between 1% to 7% for first episode of deep venous thrombosis. We present a case of the 6-year-old boy with a history of tonic clonic sizure within a period of 3 years. He subsequently developed acute aphasia and right hemiparesis. Brain magnetic resonance imaging revealed lacunar infarction. Laboratory finding showed that low level of total protein S. The patient was treated with intravenous heparin and patient completely improved. There are no evidence based strategies for the treatment of children with prothrombotic abnormality (because of the lack of research on this subject). How ever this patient completely improved and discharged with oral anticoagulant.}, Keywords = { Pediatric, protein S deficiency, CVA}, volume = {1}, Number = {2}, pages = {67-70}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-36-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-36-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2011} } @article{ author = {Pahloosye, Ali and Hashemi, Azam Sadat and Mirmohammadi, Seid Jalil and Atefi, Atef}, title = {Presenting Clinical and Laboratory Data of Childhood Acute Lymphoblastic Leukemia}, abstract ={Abstract Background Leukemia is the most prevalent childhood cancer and Acute Lymphoblastic Leukemia (ALL) constitutes 75% of all cases. The most frequent presenting symptoms are fever, weight loss and pallor. Early detection of clinical symptoms positively affects timely diagnosis. The objectives of the present study were to assess frequency of presenting symptoms, laboratory data, immune phenotypes and prognostic factors in children with diagnosis of ALL. Materials and Methods We performed a prospective follow-up study of 100 patients aged 1-16 years diagnosed with ALL, admitted to Shahid Sadoughi hospital pediatrics ward from March 2006 to February 2010. Demographic and biochemical data were obtained from their medical record. Data were analyzed using SAS 9.1.3 software. Results The mean of patients’ ages was 9 years. Complete blood cell count was abnormal in all of the patients, and pancytopenia was detected in 27% of the patients. Of all the patients, 25% had abnormal white blood cell (WBC) count at presentation, 37% had leucopenia and 38% had leukocytosis. WBC count was above 50,000/mm³ in 22% of cases. Anemia was detected in 85% of the patients. There was no significant sex difference, but a significant age difference existed among patients (p < .05). According to flowcytometry results, 61% of patients had T-cell and 39% had B-cell immune phenotype. The frequency of undesirable prognostic factors was more in T-cell than the B-cell group, but this difference was only significant for male patients (p<0.05). The most common presenting symptoms were systemic symptoms, which comprised of lethargy and malaise in 81%, anorexia in 72%, pallor in 69% and fever in 59% of cases. Musculoskeletal system was the most common system involved. Conclusion In our study, T-cell immune phenotypes comprised the most frequent form of ALL in children. The presence of male sex and high WBC count could make its outcome worse. However, on time chemotherapy could alter the outcome of these patients.}, Keywords = { Leukemia, ALL, Lymphoblastic leukemia, symptoms}, volume = {1}, Number = {3}, pages = {71-77}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-37-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-37-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2011} } @article{ author = {Hashemi, Azam Sadat and Ghilian, Rozita and Mohammadian, Rajeeh and Nodehi, Masoume}, title = {The Effects of Prophylactic Treatment of the Central Nervous System on the Intellectual Functioning Of Children with Acute Lymphocytic Leukemia}, abstract ={Abstract Objective The great majority of patients with childhood leukemia become long-term survivors. They treated with chemotherapy and prophylactic central nervous system (CNS) irradiation. The aim of this cross-sectional study was to evaluate effect of the long-term toxicity in ALL survivors, and possible effects of this treatment on their intellectual in compare with their sibling. Materials and Methods In this case-control study 40 children, 20 ALL patients and 20 their sibling, were evaluated. This study chose 20ALL patients, which they sibs were 1 or 2 years younger or older and same sex. Patients were diagnosed in Shahid Saduoghi hospital and treated with single chemotherapy (systemic and intrathecal) and radiation therapy (1800 rad). Variables such as age, treatment outcome, genesis and the effect of prophylactic treatment of the CNS on the intellectual function of ALL patients were studied and compare with their healthy sibling by Wechsler intelligent test. Results Age range was between 6 to12 years old. The mean verbal IQ score for patients was 113.25+/-13.35 and in their sibling was 113.25+/-14.74. (p=1), therefore the differences was not significant. Conclusion The mean verbal IQ score for patients that received low dose radiotherapy was in the average range. These preliminary findings provide direction for future studies to help identify high-risk patients.}, Keywords = {Central nervous system, Intellectual quotient, lymphocytic leukemia}, volume = {1}, Number = {3}, pages = {78-82}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-38-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-38-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2011} } @article{ author = {Izadpanahi, HA and Yari, Fateme and Khorramizadeh, MR and Maghsudlu, M}, title = {Evaluation of Biochemical Parameters of Platelet Concentrates Stored in Plasma or in A Platelet Additive Solution (Composol)}, abstract ={Abstract Objective Removing plasma from the platelet concentrate (PC) medium could be an effective way to increase the safety of this product. The goal of this study was to compare PC stored in plasma or in an additive solution (Composol) with in vitro testing. Materials and Methods Fifty-four single donor PCs were prepared from Iranian Blood Transfusion Organization (IBTO). Each PC unit was divided into two portions. Then in one of the portions, plasma was replaced with Composol. Sampling was carried out at the days 2, 4 and 7 from the preparation time. The levels of pH, glucose, lactate and lactate dehydrogenase (LDH) were analyzed by colorimetric methods. Results The levels of pH and glucose were decreased during storage whereas the levels of LDH and Lactate were increased with time over. At the day 7 of storage, the mean values for glucose were 404.44 and 25.19 mg/dl in plasma and Composol, respectively. These values were 3306.1 and 683.33 U/L for LDH and 142.07 and 90.90 mg/dl for lactate. The differences between LDH, lactate, and glucose levels were significant between the two storage media of plasma and Composol (P-value<0.001). Conclusion This study could imply the potential capacity of an additive solution as a candidate for plasma replacement in PC in vitro.}, Keywords = { Platelets, Additive solution, Lactate Dehydrogenize, Glucose, Lactates}, volume = {1}, Number = {3}, pages = {83-89}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = { Platelets, Additive solution, Lactate Dehydrogenize, Glucose, Lactates}, url = {http://ijpho.ssu.ac.ir/article-1-39-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-39-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2011} } @article{ author = {Behnaz, Fateme and Mohammadzadeh, Mohammad and Mohammadimoghaddam, M}, title = {Hematologic Manifestations of Brucellosis}, abstract ={Abstract Background Brucella mellitensis, the most invasive strain of brucella, is the predominant Strain of genus brucella in Iran. It causes variety of hematological abnormalities some of which are frequent and causes difficulties in diagnosis. Objective To find hematological abnormalities of brucellosis in hospitalized patients in an endemic area. Materials and Methods A retrospective review of patients' medical records who were admitted to four university and general hospitals during 8 years was done. Age, sex, clinical findings, laboratory tests including CBC, platelet count, Erythrocytic Sedimentation Rate (ESR), C-Reactive Protein, wright test were assessed. Confirmation of brucellosis was made by wright agglutination test at a titer ≥1/160. Data were analyzed by Spss16 and Pvalue <0.05 was taken as significant for differences. Results Out of 238patients diagnosed as brucellosis, hematologic evaluation had been performed for 208patients.Anemia was detected in (55/119)46%of male and (35/89) 39.3% of female patients (Pvaule0.383). Leukopenia (WBC < 4300/mm3) was present in (18/208) 8.5%, thrombocytopenia (Platelet < 150.000/ mm3) in (24/200) 12% and pancytopenia in (3/200) 1.5%of patients. Conclusion Brucellosis should be considered in differential diagnosis of any patient with disturbances of hematologic findings in endemic areas.}, Keywords = { Anemia, Leukopenia, Thrombocytopenia, Brucellosis}, volume = {1}, Number = {3}, pages = {90-93}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-40-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-40-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2011} } @article{ author = {MontazareLotfeElahi, Sima and Hashemi, Azam Sadat and Behjati, Seid Mostafa and Zaolfaghari, Farideh and Dehghani, Atefeh and Akhavaneghalibaf, Mahvash and beigomi, Mohse}, title = {The Relation between Left Ventricular Function and Serum Ferritin in Major Β-Thalassemia}, abstract ={Abstract Objective Cardiac dysfunction is a major cause of death in patients with beta thalassemia. In these patients, repeated blood transfusion, ineffective erythropoiesis and increased gastrointestinal iron absorption lead to iron overload in the body and this induced heart failure. Left ventricular ejection fraction was measured in major beta thalassemia (β-Th) patients to detect the relation of serum ferritin level and left ventricular systolic function. Materials and Methods The present prospective study evaluated 75 patients with β-thalassemia (39 female, 36 male) aged one to 44 years old. They were treated with desferal 5 days a week for at least six months. For this study they treated by desferal 7 days a week. Left ventricular ejection fraction and serum ferritin were measured before and after intervention, and they were compared for the best treatment. Results The mean ejection fraction was 60.45% and 62.9% before and after aggressive therapy, which difference was significant. Serum ferritin level also was reduced after intervention. Difference between mean ferritin before and after intervention was 49.984. Serum ferritin showed negative correlation with left ventricular function. Conclusion Lower serum ferritin concentration with aggressive therapy was associated with better left ventricular function.}, Keywords = { β- thalassemia, ejection fraction, ferritin}, volume = {1}, Number = {3}, pages = {94-97}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-41-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-41-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2011} } @article{ author = {KargarNajafi, M and Borhani, F and Dortaj, Rabari and Sabzevari, S}, title = {The Effect of Family-Centered Empowerment Model on the Mothers’ Knowledge and Attitudes about Thalassemia Disorder}, abstract ={Abstract Background Thalassemia is one of the most common human genetic diseases in the world and it provides many problems for patients, families and health care system. This model helped the family with sick children to empower to face disease and its complications. To reach this aim, the knowledge and attitude of patients and their families about the disease should be increased. This study was aimed at determine the effectiveness of family-centered empowerment model on the mothers’ knowledge and attitudes about thalassemia disorder. Objective To assess the effect of family-centered empowerment model on the mothers knowledge and attitudes about thalassemia disorder in children with thalassemia. Materials and methods This semi-experimental study was performed on 86 children with thalassemia that were randomly divided into two groups. A questionnaire was filled with demographic information and knowledge and attitude of the mothers about the disease. These questionnaires were tested for content validity and reliability (internal correlation). Information was given to first group and second group did not receive any more information. After intervention final evaluation was performed one and half month later. Results Data analysis showed that before intervention, the average awareness and attitude of the mothers in test group were no significantly different with control group (p>0.05). However, after performing model in the test group, this averages were significantly higher in test group than control (p<0.05). Conclusions The results of this study indicated that implementation of the family-centered empowerment model are effective on knowledge and attitudes of mothers of children with thalassemia.}, Keywords = { Children Thalassemia, Empowerment, Knowledge, Attitude, Mothers}, volume = {1}, Number = {3}, pages = {98-103}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-42-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-42-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2011} } @article{ author = {Hashemi, Azam Sadat and Kargar, Fateme and Souzani, Azade and Hazar, N}, title = {Acute Immune Thrombocytopenic Purpura in Infants}, abstract ={Abstract Objective Immune thrombocytopenic purpura (ITP) manifests as an easy bruising or extravasation of blood from capillaries into skin and mucous membranes. The characteristics of acute ITP in infants have rarely been described. In order to better understand acute ITP in infants, the characteristics of the disease at this age group was investigated. Material and Methods The present descriptive, cross-sectional study, variables such as age, sex, clinical presentation, treatment outcome, and the rate of chronicity in 72 infant suspected to ITP on admission were evaluated from 2002 to 2008 at Yazd Shahid Sadoughi Hospital. Results Analyzing data showed among 72 cases, 31 were female and 41 were male aged 15 days to 2 years old. According to the result of bone marrow aspiratation, 66 patients had ITP, 2 had Wiskott Aldrich and 4 patients had Fanconi anemia. Clinical presentations of the patients with ITP were as following: 55 patients (83.3%) had purpura, 27 (40.9%) active mucosal bleeding and 2 (3%) had intra cranial hemorrhage. According to the history of patients 31 patients (47%) had common cold, 17 (25.8%) were positive for vaccination, 2 (3%) had a history of chickenpox. They all had good response to treatment. There was no significant relationship between sex and disease progression towards the chronic phase (Pvalue: 0.554). A total of 16 chronic ITP had complete response to treatment (with IVIG and corticosteroids, Anti D, Azathioprine). Conclusion ITP in infant is a benign disease and responds well to treatment. Vaccination and viral illnesses play an important role in the etiology of ITP in children.}, Keywords = { Infant, Age, Acute, Chronic, ITP}, volume = {1}, Number = {3}, pages = {104-110}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-43-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-43-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2011} } @article{ author = {Lookzadeh, Mohammad H and Moghimi, M and AtaeeNakhaei, MH}, title = {Peripheral Symmetrical Gangrene of the Neonatal Extremities : A Case Report}, abstract ={Abstract Background Limb gangrene in neonates is an extremely rare clinical problem and very few cases have been recorded up to now. The clinical findings were mild involvement of skin to full necrosis and gangrene of the involved regions. Unfortunately, in most cases the etiology cannot be established. However, a variety of etiological causes may account for this condition. Case Presentation We present a newborn baby with symmetrical peripheral gangrene of the limbs, both flanks, chin, and scrotum due to leukocytoclastic vasculitis with unknown cause. He was treated by parenteral glucocorticoid, broad-spectrum antibiotics, heparin, hydralazine and fresh frozen plasma (FFP). He died after 2 weeks of intensive treatment. There is history of the same disease in two infants of his paternal aunt, both of them were dead soon after birth. Conclusion Peripheral gangrene with symmetrical involvements, due to vasculitis, is a very unique disorder in newborn infant, which no case was reported up to now.}, Keywords = { Neonates, Leukocytoclastic Vasculitis, gangrene}, volume = {1}, Number = {3}, pages = {110-114}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-44-en.html}, eprint = {}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2011} } @article{ author = {Mirbehbahani, NB and Rashidbaghan, A and Nodehi, H and Jahazi, A and Behnampour, N and Jeihounian, M and Payab, Z}, title = {Immunophenotyping of Leukemia in Children, Gorgan, Iran}, abstract ={Abstract Background Leukemia is one of the most common tumors in children and it is divided up into two main groups acute and chronic leukemia. The acute leukemia is more prevalent than chronic in children. Generally acute type is included acute lymphoid leukemia (ALL) and acute myeloid leukemia (AML). In this study, patients with leukemia who were admitted in Talghani hospital of Gorgan were examined for immune markers. Materials and Methods Forty one patients (34 persons with ALL and 7 persons with AML) were examined. Bone marrow aspiration samples were obtained in tubes containing EDTA and were sent to pathology center of Baghiatallah hospital, Tehran. Immunophenotyping was conducted by Flow cytometry and results were recorded in profiles of patients. Results The mean age of ALL and AML patients was 5.64±3.43 and 7.45±5.68 years respectively. It was determined that ALL risk in males is 1.086 times more than females. Mann-Whitney test did not show significant difference between mean age of AML and ALL groups (p=0.5). Highest markers in ALL were CD19 (90.2%), CD10 (84.36%), I3 (HLA-DR) (70.58%), and in AML CD45 (81.8%), I3 (HLA-DR) (63.64%) and CD34 (54.5%). Conclusion The prevalence of markers in ALL and AML patients is different, and some of them are common. These results could be used for differentiation of ALM from ALL. Further study was recommended on bigger sample-size to achieve a definite conclusion.}, Keywords = {Leukemia, Child, Immunophenotyping}, volume = {1}, Number = {4}, pages = {115-120}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-45-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-45-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2011} } @article{ author = {TaghipourZahir, Shokoh and Rezaeisadrabadi, Mohammad and Dehghani, F}, title = {Evaluation of Diagnostic Value of CT Scan and MRI in Brain Tumors and Comparison with Biopsy}, abstract ={Abstract Background Cerebral neoplasm arises from brain, spinal cord and meningeal cells. Not only malignant cerebral neoplasm also benign tumor could lead to death due to mass effect on vital structures. Access to these tumors is difficult, and MRI and CT scan could be helpful in determining anatomical location of tumors and distinction of malignant from benign. Objective For better and earlier diagnosis and treatment, present study determined the accuracy of MRI and CT scan in compare with pathological findings. Materials and Methods This experimental case-series study compare the results of tumor imaging (MRI and CT scan) with biopsy in patients who came with brain mass between April 2004 and April 2010. Demographic characteristic and medical history were recorded. The results of CT scan, MRI and biopsy reports were recorded for patients, and all data compared and analyzed by SPSS software version 15. Results Results of 218 patients were analyzed. 189 patients had definite diagnosis using CT scan, which 13 (7.2%) were diagnosed benign and 159 (92.4%) malignant. Sensitivity, specificity, positive predictive value and negative predictive value of CT scan in comparison with biopsy were 83%, 10%, 93% and 3% respectively. The accuracy of this method was 78%. Fifty four patients (24.4%) were evaluated by MRI. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of MRI were 92%, 25%, 93%, 2% and 87% respectively. Conclusion According to the results, positive results by MRI and CT scan are valuable and have diagnostic value, but negative reports need more evaluation and no roll out malignant tumor. So remarkable specificity, but low sensitivity were achieved for CT scan and MRI. They accepted as easier and more accessible methods to approach brain tumors.}, Keywords = {Brain Neoplasms, Computerized Tomography, Magnetic Resonance Imaging, Biopsy}, volume = {1}, Number = {4}, pages = {121-125}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-46-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-46-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2011} } @article{ author = {Hashemi, Azam Sadat and Ayatolahi, Vida and Ghilian, Rozita and GhadamiYazdi, Ali and Fadavi, Nafisa and Yadegar, Yaser and Shahri, Tayebe and MirAkhor, M and AskariNodoshan, A and PourMohammadiShahrbabaki, T}, title = {Ketofol for bone marrow aspiration and lumbar puncture in Children with ALL}, abstract ={Abstract Background Ketofol is usually using as a sedative drug during painful procedures now. That Provides sedation, analgesia and rapid recovery. The aim of this study was to compare the efficacy, respiratory and hemodynamic profiles, and side effects of two various combination of ketamine and propofol in patients undergoing bone marrow aspiration (BMA) and lumbar puncture (LP). Materials and Methods This randomized, double blinded study was designed to compare the quality of analgesia and side effects of intravenous ketofol in sixty boys and girls. In this study Patients received a slow bolus injection of a solution containing combination of equal amount of propofol and ketamine (1:1) (Group I) or two parts of propofol plus one part of ketamine (2:1) (Group II). Subsequent slow bolus injects to a predetermined sedation level using Ramsay Sedation Scale. Vital signs, oxygen saturation (SpO2) and incidence of any side effects were recorded. Results Ketofol was used in 49 surgical procedures in children with a median age of 5 years (1 to 10 years old). In this study there was an increase postoperative nausea, psychomimetic side effects, and increase recovery time with the largest ketamine dosage (Group I). (P-value<0.001) Conclusion The adjunctive use of smaller dose of ketamine in ketofol combination minimizes the psychomimetic side effects and shortens the recovery time. A large number of patients are required to evaluate and validate these findings.}, Keywords = {Propofol, Ketamine, Child, Analgesia}, volume = {1}, Number = {4}, pages = {126-132}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-47-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-47-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2011} } @article{ author = {Keikhaei, B and Idani, E and Samadi, B and Titidage, A}, title = {Pulmonary Spirometry Parameters in Patients with Sickle Thalassemia and Sickle Cell Disease at Shafa Hospital in Khuzestan Province-Iran}, abstract ={Abstract Background Prevalence of hereditary blood diseases such as sickle cell anemia, sickle thalassemia and thalassemia major are high in Khuzestan province. Sickle cell anemia and beta-thalassemia are predominantly common in Iranian Arabs. Pulmonary complications account for a large proportion of morbidity and mortality in patients with and sickle cell disease. Periodic lung function assessment is recommended to provide a diagnostic clue criterion for physicians. Objective The purpose of this study is to assess the spirometry parameters in patients with sickle beta thalassemia and sickle cell disease in south west Iran. Materials and Methods Over three months, a total of 35 patients participate in this cross sectional study. Spirometry test was performed on 21 patients with sickle cell disease (12 male, 9 female) and 14 patients with sickle beta thalassemia (7 male, 7 female) aged 6to35 years old. Normal people were matched according to age and sex and were tested as control. Results Eighty six percent of sickle cell disease and 57 percent of sickle beta thalassemia had restrictive pattern of lung disease. Forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) correlated positively with Hb F level and negatively with Hb S level (P-value<0.001) in sickle cell disease patients (P-value<0.001). Serum ferritin level had a negative effect on FEV1 and FVC in sickle beta thalassemia patients. Conclusion Periodic lung function tests are a useful monitoring test to provide a clinical evaluation profile and have positive correlation with Hb F level.}, Keywords = {Anemia, Sickle Cell, beta-Thalassemia, Spirometry}, volume = {1}, Number = {4}, pages = {133-139}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-60-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-60-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2011} } @article{ author = {Noori-Shadkam, Mahmoud and Niknafs, P and Mozaffari-Khosravi, Hasan and Bahman-bijari, B}, title = {The Effect of Early Subcutaneous Administration of Erythropoietin on Hematopoiesis and Weight Gain Velocity in Preterm Infants}, abstract ={Abstract Introduction Anemia in preterm infants is identified as hemoglobin lower than 7-10g/dl around 1-3 months after birth. The aim of this study was to evaluate the effect of early subcutaneous administration of erythropoietin on hematopoiesis and weight gain velocity in preterm infants. Materials and Methods The present study was clinical trial carried out on 42 preterm infants. Those whose weight was lower than 1800 g at birth and gestational age of less than 34 weeks were included in the study. The subjects were randomly assigned into two groups. Intervention (IG) and control (CG). The IG received 500 IU/kg of subcutaneous erythropoietin twice a week while there was no intervention with the control group. Both groups received iron supplement, vitamin A, D, E and folate daily. Measuring ferritin as well as reticulocyte, hematocrit, and hemoglobin were accomplished in each group before and after the treatment. SPSS11 software was used to analyze the data. Results Totally there were 19 boys (51.4%) and 18 girls (48.6%) in this study. there was an increase in the number of reticulocytes in IG after the intervention (P=0.004). Weight gain was also higher in this group (P=0.005). The mean systolic blood pressure, however, was not significant in both groups after the intervention (P=0.36). Two infants needed transfusion of packed RBCs in the CG while for IG this was not happened. Conclusion Early use of human recombinant erythropoietin results in erythropoiesis as well as weight gain in preterm infants.}, Keywords = { Infant, Erythropoietin, Anemia, Blood Transfusion, Weight Gain}, volume = {1}, Number = {4}, pages = {140-146}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-48-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-48-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2011} } @article{ author = {Hashemi, Azam Sadat and Ghilian, Rozita and Golestan, Motahare and AkhavanGhalibaf, Mahvash and Zare, Z and Dehghani, Mohammad A}, title = {The Study of Growth in Thalassemic Patients and its Correlation with Serum Ferritin Level}, abstract ={Abstract Background Beta-thalassemia is a common hereditary hemoglobinopathy, which is a reason of microcytic hypochromic anemia. Patients with major thalassemia require multiple blood transfusions. This study evaluated growth in thalassemic patient and relationship with ferritin level. Materials and Methods This is a cross sectional study on seventy patients (36 boys, 34girls) with transfusion dependent major thalassemia at the special diseases center of Yazd. Their age rang was 2 to 28 year. All of them received chelating therapy (Deferoxamine) every night. Weight, height, body mass index (BMI) and serum ferritin of patients were recorded. Results In this study 46 (65.71%) of patients had height less than five percentile, and 24(34.29%) more than five percentile. Thirty eight patients (54.28%) had weight more than five percentile and 32(45.71%) less than five percentile. BMI of 13(18.6%) patients were low and 57(81.4%) patients had normal BMI. Mean serum ferritin in patients with height more than 5 percentile was 2252+/-1040 and with height less than 5 percentile was 2962+/-1606(P-value=0.072). mean serum ferritin in patient with weight more than 5 percentile was 2309+/-1284 and with weight less than 5 percentile was 3199+/-1545 ( P-value=0.017). In patient with normal BMI, mean serum ferritin was 2679+/-1378 and it was 2596+/-1777 with low BMI. Conclusion High serum ferritin levels during puberty cause delay of growth retardation and development in transfusion dependent thalassemia patients. Key words beta-Thalassemia, Growth, Deferoxamine, Blood Transfusion}, Keywords = { beta-Thalassemia, Growth, Deferoxamine, Blood Transfusion}, volume = {1}, Number = {4}, pages = {147-151}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-49-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-49-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2011} } @article{ author = {Dehghani, Khadijeh and Poormovahed, Zahra and Dehghani, Hamideh}, title = {Socioeconomic Status and Childhood Leukemia}, abstract ={Abstract Introduction Connection of socioeconomic status measures (such as income and education and parental addiction) to childhood leukemia are likely to vary with place and time. The aim of this study was to assess the relation between socioeconomic status and childhood leukemia. Materials and Methods a case- control study conducted on 86 case of acute lymphoblastic leukemia age 0-14 years in Shahid Sadoughi Hospital in Yazd and matched on age and sex to 188 healthy controls. Data was collected by interview using a questionnaire. Data analyzed by chi-square test. Odds ratio (Ors) and 95% confidence intervals were used to measure the risk of childhood A.L.L associated with parental smoking, alcohol drinking & addiction. Results There was a significant difference in parental education level (P-value=0, P-value=0.001), income status (P-value =0.001), father's job (0.002) between two groups. The risk of childhood A.L.L was associated with paternal smoking (P-value =0.001, OR=2.6, CI 95%, 1.5-4.5), alcohol drinking (P-value=0.003, OR=3.33, CI 95%, 2.7-3.9), addiction (P-value =0, OR=42.7, CI95%, 5.56-328.34). Conclusion The results suggest that socioeconomic factors and paternal smoking and alcohol drinking are related to risk of childhood leukemia. It should be considered for planning support.}, Keywords = { Precursor Cell Lymphoblastic Leukemia-Lymphoma; social class; Smoking; Alcohol Drinking; Behavior, Addictive}, volume = {1}, Number = {4}, pages = {152-158}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-50-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-50-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2011} } @article{ author = {Besharati, Mohammad Reza and TaghipourZahir, Shokuh and Hashemi, Azam Sadat and Eshaqhiyeh, Zahr}, title = {Malignant Lymphoma of Lacrimal Apparatus in the 7 Year Old Girl}, abstract ={Abstract Background Involvement of lacrimal apparatus by Non Hodgkin lymphoma as a first manifestation is extremely rare and only three cases have been reported in children. The purpose of this report is to determine the clinical characteristic of patient with primary involvement of lacrimal apparatus with lymphoma. Case presentation A 7-year-old girl with history of tearing, gradually progressive periorbital redness and painless swelling over right lacrimal apparatus for almost 40 days was referred for treatment in our clinic. Orbital computed tomography revealed lacrimal apparatus mass. Histopathological examination demonstrated B cell type NHL. Following three cycles of cyclophosphamide, doxorubicin hydrochloride, vincristine and prednisone (CHOP regimen) and radiotherapy, the patient was discharged with good condition. Conclusion Although, the primary lacrimal apparatus lymphoma is extremely rare in children but malignant lymphoma should be taken under consideration in acute dacriocystitis.}, Keywords = { Lymphoma, Non-Hodgkin, Orbit, Lacrimal Apparatus, Dacryocystitis}, volume = {1}, Number = {4}, pages = {159-162}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-51-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-51-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2011} }