@article{ author = {Ansari, Sh and Shirzadi, E and Elahi, M}, title = {The Prevalence of fungal infections in children with hematologic malignancy in Ali-Asghar Children Hospital between2005 and 2010}, abstract ={Background A fungal infection represents a growing problem in children with hematologic malignancies,during chemotherapy induced neutropenia.Fungal colonization is considered a major riskfactor for subsequent fungal infections. The aim of this retrospective study was to evaluate prevalence of fungal infection among children admitted to hospital between 2005 and 2010 in Tehran, Iran. Materials and Methods 617 hematological patients in the age range of neoteric to 19 years old were enrolled and 87 cases with invasive fungal infections were extracted from patients' files and documented. Diagnosis of fungal infections was based on the blood culture, urine culture and clinical examination for candidasis and galactomannan for aspergillus. Results the mean age of cancer diagnosis was 6.33 years old and the mean age of fungal infection was 7.95 years old. The majority of the infections was caused by candidia spp (74.7%), followed by aspergillus spp (17.2%) and zygomycetes (11.5%). Among candidiasis patients, oral infection had the highest manifestation (92.3%) whereas in 10 of 15 patients with aspergillus, the infectious site was the lung. There was a significant association between mortality and the type of fungal infection (p <0.0001). Conclusion Our finding suggests that there is a high rate of fungal infections in children receiving remission therapy for onco-hematology. These results help improve the management of these patients, however Further studies are needed.}, Keywords = {Candidiasis, Aspergillosis, Mucormycosis, Hematologic malignancy, Children}, volume = {5}, Number = {1}, pages = {1-10}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-190-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-190-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Shahramian, I and Noori, NM and Teimouri, A and Akhlaghi, E and Sharafi, E}, title = {The Correlation between Serum Level of Leptin and Troponin in}, abstract ={Background Polypeptide hormone Leptin suppresses inflammation in the heart muscle and protects heart from diseases. The purpose of this study is to evaluate the relationship between leptin and troponin serum levels with cardiac involvement in patients with major beta thalassemia. Materials and Methods In this cross-sectional study, 70 children with major thalassemia were selected. Two ml blood was taken as sample from all children and after separating serum the samples were maintained in -20°C temperature. Then, regarding cold chain conditions, the sample were sent to the Biochemistry Lab. Afterwards, leptin and troponin serum levels with the relevant kits and BMI were measured in all children, and information about age and gender was recorded. Collected data were analyzed with SPSS. Results The mean of leptin in girls and boys were 2.47 ± 3.13 and 0.96 ± 1.08 respectively which showed a significant difference (t=2.74, p =0.009). A significant correlation was also observed between BMI and leptin (r = 0.374, P = 0.002). Another significant association was found between leptin and age (r = 0.248, P = 0.041). However, a significant inverse correlation between serum ferritin and age (r = - 0.607, P = 0.0001) was discovered. No correlation was found between leptin, troponin, and ferritin. Conclusion Since Leptin increases with the advent of cardiac involvement and independent from troponin T, it can be a predictive marker of cardiac involvement in patients with major beta thalassemia.}, Keywords = {Leptin, Major beta thalassemia, Troponin}, volume = {5}, Number = {1}, pages = {11-17}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-191-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-191-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Ahmadi, M and Jahani, S and Tabesh, H and Poormansouri, S and Shariati, A}, title = {The Effectiveness of self management program on quality of life in patients with sickle cell disease}, abstract ={Background Sickle cell patients suffer from many physical, psychological, and social problems that can affect their quality of life. To deal with this chronic condition and manage their disease and prevent complications associated with the disease, they must learn skills and behaviours. The aim of this study was to determine the effectiveness of self-management programs on quality of life in these patients. Material and Methods Samples of this quasi-experimental study, which included 69 patients with sickle cell disease referring to the Thalassemia Clinic of Shafa Hospital, were entered into the study by census method. Patients received a self-management program using the 5A model for 12 weeks, while their quality of life before the intervention were assessed at the twelfth week and thirty-sixth week using SF-36 questionnaire. Data were analyzed by descriptive statistics, paired t-test, Wilcoxon test, Hotelling's T2, and repeated measures test. Results The eight dimensions and the total QoL score after intervention were significantly increased compared to those before the intervention (P<0.001). Repeated measures test showed that the mean score of eight QoL dimensions and the total QoL score decreased in the thirty-sixth week, compared to twelfth week. However, it was significantly enhanced in comparison with the intervention baseline (P<0.05). Conclusions Current study revealed the efficacy of self-management interventions on the quality of life in patients with sickle cell disease. Therefore, application of this supportive method could be useful to empower the patients and help them to manage the disease.}, Keywords = {Self-management, Quality of life, sickle cell}, volume = {5}, Number = {1}, pages = {18-26}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-192-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-192-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Sakhinia, E and Estiar, MA and Andalib, S and Rezamand, A}, title = {Expression Profiling of Microarray Gene Signatures in Acute and Chronic Myeloid Leukaemia in Human Bone Marrow}, abstract ={Background Classification of cancer subtypes by means of microarray signatures is becoming increasingly difficult to ignore as a potential to transform pathological diagnosis nonetheless, measurement of Indicator genes in routine practice appears to be arduous. In a preceding published study, we utilized real-time PCR measurement of Indicator genes in acute lymphoid leukaemia (ALL) and acute myeloid leukaemia (AML) as a way of application of microarray gene signatures. More to the point, the specificity of such genes for this distinction was investigated by their measurement in cases afflicted with chronic myeloid leukaemia (CML) and with normal bone marrow (BM). Material and Method Mononuclear cells were sorted into unselected (total), CD34+ve, and CD34-ve fractions, mRNA globally amplified by using PolyA PCR. Moreover, the level of expression of 17 Indicator genes was identified by using real-time PCR. Results No statistically significant difference was observed in expression for any gene among CML cases. Cyclin D3 (p≤0.04) was exclusively upregulated in CML in the CD34+ fraction, notwithstanding upregulation of HkrT-1 (p≤0.02) and fumarylacetoacetate (p≤0.03) in AML. HOXA9 experienced a non-significant upregulation in AML however, in combination with proteoglycan 1 distinguished between AML and normal samples in the CD34- fraction in unsupervised clustering. Unsupervised clustering distinguished among AML and the other diagnostic groups. Conclusion The evidence from the present study suggests that the genes discriminatory between ALL and AML are uninformative in the context of CML and normal BM, excepting for distinction with AML.}, Keywords = {Microarray, PolyA PCR, RT-PCR, Gene Signature, Myeloid Leukaemia }, volume = {5}, Number = {1}, pages = {27-42}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-193-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-193-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Ghotaslou, A and Nadali, F and Ghasemi, A and Chahardouli, B and Abbasian, S and Rostami, S}, title = {Low Frequency of C-MPL Gene Mutations in Iranian Patients with Philadelphia-Negative Myeloproliferative Disorders}, abstract ={Background Myeloproliferative disorders are a group of diseases characterized by increased proliferation of myeloid lineage. In addition to JAK2V617F mutation, several mutations in the c-MPL gene were described in patients with Philadelphia-negative chronic myeloproliferative disorders that could be important in the pathogenesis of diseases. The aim of present study was to investigate the frequency of c-MPL and JAK2V617F mutations in Iranian patients with Philadelphia-negative myeloproliferative disorders. Material and Methods Peripheral blood samples from 60 patients with Philadelphia-negative MPD) subgroups ET and PMF) and 25 healthy subjects as control were collected in order to investigate the mutation status of c-MPL and Jak2V617F by using Amplification-Refractory Mutation System (ARMS) and Allele-Specific PCR (AS-PCR), respectively and results were confirmed by sequencing. Results Among the total 60 patients studied, 34 (56.6%) and 1(1.7%) had Jak2V617F and c-MPL mutation, respectively. Patients with Jak2V617F mutation had higher WBC counts and hemoglobin concentration than those without the mutation (p= 0.005, p=0.003). In addition for all healthy subjects in control group, mutation was negative. Conclusions The present study revealed that the c-MPL mutations unlike the Jak2V617F mutations were rare in Iranian patients with Ph-negative MPNs and the low mutation rate should be considered in the design of screening strategies of MPD patients.}, Keywords = {ARMS –PCR, c- MPL mutation, JAK2V617F, Myeloproliferative Disorders}, volume = {5}, Number = {1}, pages = {43-51}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-194-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-194-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Gheibi, Sh and Farrokh-Eslamlou, HR and Noroozi, M and Pakniyat, A}, title = {Refractory iron deficiency anemia and Helicobacter Pylori Infection in pediatrics: A review}, abstract ={Background Since the discovery of Helicobacter pylori, several clinical reports have demonstrated that H. Pylori infection has emerged as a new cause of refractory iron stores in children. We carried out a systematic literature review to primarily evaluate the existing evidence on the association between childhood H. Pylori infection and iron deficiency anemia (IDA) and secondly, to investigate the beneficial effects of bacterium elimination. Material and Methods This review concerns important pediatric studies published from January 1991 to October 2014. Fourteen case reports and series of cases, 24 observational epidemiologic studies, seven uncontrolled trials, and 16 randomized clinical trials were included in the review. Results Although there are a few observational epidemiologic studies and some randomized trials mostly due to the potential confounders, most studies reported a positive association linking between H. Pylori infection and iron deficiency or iron deficiency anemia among children. In addition, it seems that elimination of H. Pylori infection induces beneficial effects on iron deficiency. Conclusions Since the evidence for the association of H. pylori eradication therapy and refractory childhood IDA is not enough and there are contrasting data about such association, future high quality and cohort researches are needed to determine the causal association.}, Keywords = {Iron deficiency anemia, Helicobacter Pylori Infection, pediatrics}, volume = {5}, Number = {1}, pages = {50-64}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-195-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-195-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Farhangi, H and Sharifi, N and Ahanchian, H and Izanloo, A}, title = {Autoimmune Hemolytic Anemia preceding the Diagnosis of Primary Central Nervous System Lymphoma}, abstract ={In this study, a 2.5-year-old boy suffering from a febrile seizure with normal laboratory tests and a history of immune hemolytic anemia was examined. Brain MRI demonstrated some tumors in the frontal, parietal, and occipital lobe that corroborated the pathology results of primary central nervous system lymphoma for the patient. The patient was treated with high- dose of Methotrexate. Our result suggested regular and careful monitoring of patients with autoimmune hemolytic anemia in order to control the manifestations of concomitant disease such as lymphoma that may develop later}, Keywords = {Anemia, Lymphoma, Nervous System, MRI}, volume = {5}, Number = {1}, pages = {65-69}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-196-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-196-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Dalili, S and Baghersalimi, A and Jafroodi, M and Atrkarroshan, Z and Koohmanaei, SH}, title = {Association between height and malignancy among children in the north of Iran}, abstract ={Background This study aim to determine the association between height and cancer in the children aged 14 years at the time of diagnosis in Rasht, Iran. Materials and Methods In this cross-sectional study, height of patients with a malignancy (≤14) at the time of diagnosis measured in the standard charts of United States National Center for the Health Statistics (NCHS). Data were reported by descriptive statistics and analyzed by Regression tests in SPSS version 19. Results Overall, 78 male (38.6%) and 124 female (61.4%) patients with various kinds of malignancies were evaluated for their heights. Leukemia was the most common type of cancer. The median height of the patients was more than 20th percentile and under 50th percentile of the NCHS. No significant association was found between height and leukemia. Conclusion Previously, the median height of Iranian girls and boys (≤15) reported under 20th percentile of the NCHS. In this study, the median height of the patients at the time of diagnosis was more than 20th percentile of the NCHS. There was a correlation between height and cancer among our patients, although, this correlation can be assessed by further cohort study.}, Keywords = {Height, Pediatric, Malignancy, NCHS, Percentile}, volume = {5}, Number = {2}, pages = {70-76}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-198-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-198-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Farhangi, H and Badiei, Z and Moharreri, F}, title = {Prevalence of Psychiatric Symptoms in ALL Patients during Maintenance Therapy}, abstract ={Abstract Background Cancer diagnosis may cause deep emotional and affective problems in patients and their families.Nowadays, however, despite its rising prevalence,cancer is no longer synonymous with death. Given the significance of emotional well-being in cancer patients, we decided to assess the frequency of psychological problems in seven to seventeen yearolds with acute lymphoblastic leukemia. Methods Our sample included 42 children and adolescents with ALL referred to pediatric hematology department of Dr. Sheikh hospital, who were put under maintenance course of the treatment.Psychiatric disorders such as anxiety, depression and behavioral disturbances were examined by using RCMAS, CDI and SDQ questionnaires respectively. Results The entire population showed depressive symptoms.59.5% of patients (25 person) suffered from anxiety and 26.2% (11 person) had behavioral problems. No significant relation was found between depressive symptoms, and age (p=0.77), sex (p=0.97), length of disease (p=0.50), and type of treatment (p=0.064). Anxiety did not show any significant relation with age (p= 0.63), sex (p= 0.32), length of disease (p= 0.16) and treatment type (p= 0.064).Similarly behavioral disturbances did not indicate any suggestive relation with age (p= 0.20), sex (p= 0.56), length of disease (p= 0.81) and type of treatment (p= 0.19). Conclusion Our findings suggest a high prevalence of psychiatric disorders in children and adolescents with ALL. It is strongly recommended, therefore, that besides somatic symptoms, careful attention be paid to psychological disorders. This can prevent rapid development of the disease reduce treatment costs, and improve the quality of life for both patients and their families.}, Keywords = {Anxiety, depression, behavioral disorders, children and adolescents, acute lymphoblastic leukemia}, volume = {5}, Number = {2}, pages = {77-82}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-199-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-199-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Eghbali, A and Taherahmadi, H and Bagheri, B and Nikanjam, S and Ebrahimi, L}, title = {Association between serum ferritin level and diastolic cardiac function in patients with major β-thalassemia}, abstract ={Abstract Background Prevention of myocardial siderosis is a key step to reduce rate of mortality in thalassemic patients. Our objective was to study association between echocardiography parameters and serum ferritin level in patients with major thalassemia. Materials and Methods Sixty-six patients with major thalassemia were studied in Amir Kabir hospital, Arak, Iran. Serum ferritin levels were measured during 3 months in patients with no symptoms of infection. It was measured by enzyme-linked immunosorbent assay (ELISA). Ejection Fraction (EF), Fractional Shortening (FS) and Early/Late ratio (E/A) were studied by echocardiography. Results Fifty two percent were female and 48% were male. Mean age was 16 ± 9 years and the age range was3-26years. Mean serum ferritin level was1912 ± 1748 ng/dl and its range was from 303 to 8333 ng/dl. There were significant correlations between serum ferritin level and EF(r=0.3 and P=0.05) and also between serum ferritin level and FS. Conclusion Due to significant association between serum ferritin level and echo parameters, it is beneficial that all patients with major thalassemia undergo echocardiography to gain better understating about cardiac function.}, Keywords = {Thalassemia, Ferritin, Echocardiography, Ejection fraction, diastolic dysfunction}, volume = {5}, Number = {2}, pages = {83-88}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-200-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-200-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {FattahiBafghi, A and Hashemi, A and Abolhasanizadeh, S}, title = {Comparison of hematological aspects among children with Malaria and healthy children}, abstract ={Abstract Background Malaria is an acute and chronic illness characterized by paroxysms of fever, chills, sweating, fatigue, anemia, and splenomegaly. Most malarial deaths occur in infants and young children.Anemia in malaria has diverse pathophysiologic mechanisms such as direct invasion of Red cells, In the following, we presented comparison of hematological aspects: children with Malaria and healthy children. Materials and Methods This was a lab trial study. Patients were referred and admitted to the pathobiology laboratory along with physical examination. Then, they underwent a complete blood count and the result of complete blood count was compared with healthy person in the same age. Out of 30 patients, with equally falciparum, vivax, and healthy .The hematological examination was performed. Finally, the data was analyzed using SPSS version 19 software. Results The levels of HGB (P=0.001), HCT (P=0.001), MCV (P= 0.001), MCH (P=0.001), WBC (P=0.001), and Plt (P= 0.02) decreased significantly in children with falciparum and vivax malaria compared to healthy controls. The levels of RBC (P=0.49) increased significantly in children with falciparum and vivax malaria compared to controls. Blood culture at two times. To investigate malaria blood smears taken after microscopic study of Plasmodium falciparum ring was observed. Conclusion Malaria is a multisystem disorder which can lead to many diseases. Physicians, especially those in endemic areas, should be aware of the varied manifestations and maintain in a high index of suspicion for the disease in order to that diagnose and treat timely and, morbidity and mortality.}, Keywords = {Malaria, Hematological aspects, Plasmodium, Falciparum, Vivax,Children}, volume = {5}, Number = {2}, pages = {89-92}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-201-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-201-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Vaziri, M and JavadzadehShahshahani, H and Moghaddam, M and Taghvaee, N}, title = {Prevalence and specificities of red cell alloantibodies in transfusion-dependent beta thalassemia patients in Yazd}, abstract ={Abstract Background Multiple transfusions in thalassemia patients may lead to antibody production against blood group antigens and hemolytic transfusion reaction might occur. In this study, antibody screening test was performed by tube and gel methods to determine the prevalence and specificity of alloantibodies in thalassemia patients. Materials and Methods In this cross-sectional study, overall of 100 thalassemia patients from Yazd thalassemia clinic were recruited from July to September 2013. Two blood samples with volume of 6 ml were collected from each patient for standard tube and gel method antibody screening tests and a questionnaire consisting of demographic, health and blood transfusion status was completed. Results Out of 100 cases, 54 were female (54%) and 46 male (46%). The patients;#39 age mean was 14.97±7.91 years with 2 to 33 years age range. Only 4% (n=4) had developed alloantibodies. (One patient developed dual alloantibody (Anti-C and Anti-D) and three patients developed single alloantibody (Anti-K)).Gel method detected 4 patients with alloantibody but in two patients not detected by the standard tube method. Conclusion The prevalence of RBC alloantibody production in this study was less than most previous studies. Anti-K was the most prevalent alloantibody in thalassemia patients in Yazd. It seems Rh and Kell blood group phenotyping in a newly diagnosed thalassemia patient and selection of matched blood for transfusion is very important.}, Keywords = {Alloantibody, Thalassemia, Transfusion}, volume = {5}, Number = {2}, pages = {93-99}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-202-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-202-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Robati, R and MirahmadiNejad, A}, title = {Awareness and performance of blood transfusion standards in operating rooms of Shiraz hospitals in 2012}, abstract ={Abstract Background Assuring safety and survival of blood in vitro depends on anti-coagulation substances, blood bag characteristics, storage conditions, and transport of blood. Besides, careful selection and screening of donors as well as blood tests can minimize the transmission risk of blood-transmissible pathogens and optimize blood health. The aim of this study was to assay the level of knowledge and practices among anesthesia technicians on blood transfusion standards. Materials and Methods This descriptive cross-sectional study was performed among 85 anesthesia technicians Shiraz, Iran throughout 2012 who were examined by census using blood transfusion questionnaires and checklists. The data were analyzed using SPSS 16 software. Results The obtained findings indicated that 32.44% of the technicians have corrected knowledge of blood transfusion standards nevertheless, 73.84% have corrected performance. Conclusions The technicians mostly performed based on their habit and experience. However, their knowledge about blood transfusion and blood bag storage was low.}, Keywords = {Blood Transfusion, Reference Standards, Operating Rooms, Hospitals, Shiraz.}, volume = {5}, Number = {2}, pages = {100-105}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-203-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-203-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Hashemi, A and Bahrololoumi, Z and Khaksar, Y and Saffarzadeh, N and Neamatzade, H and Foroughi, E}, title = {Mouth-rinses for the prevention of chemotherapy induced oral mucositis in children: a systematic review}, abstract ={Abstract Background The purpose of this review was to evaluate studies in basic oral care interventions to update evidence based practice guidelines for preventing oral mucositis (OM) in cancer patients undergoing chemotherapy. Material & Methods Pub Med database and Google Scholar were searched for all papers published between 2000 and December 2014 in English that were conducted using the search terms including ‘‘mocusitis, chemotherapy, mouth-rinses, oral care, oral care protocol, dental care,dental cleaning, oral decontamination, oral hygiene”, and the combined phrases in order to obtain all relevant studies. Results The initial search concluded 151 published papers representing both research and clinical work. Review articles, clinical case reports, literature reviews, and other nonresearch articles were excluded from the review. Following this process, 30 papers remained. Conclusion Among these, chlorhexidine, normal saline, sodium bicarbonate, iseganan, benzydamine, sucralfate and Granulocyte macrophage colony-stimulating factor have been used in the form of mouth-rinse for prevention of chemotherapy induced mucositis. However, none of these mouthrinses have been shown to be definitely effective in preventing chemotherapy induced oral mucositis.}, Keywords = {}, volume = {5}, Number = {2}, pages = {106-112}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-204-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-204-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Bordbar, M and Bazrafshan, A and Karimi, M}, title = {Successful Management of Vinblastin Overdose with Exchange Transfusion: A Case Report}, abstract ={Accidental overdose of chemotherapy drugs including vinblastin (VBL) have been reported in the literature. As VBL overdose is potentially fatal, we decided to introduce a 2-year-old girl affected by langerhans’ cell histiocytosis who was accidentally injected 10-times the prescribed dose of VBL (16 mg), and was saved with whole blood double exchange transfusion at 8 and 20 hrs after the accidental injection. The earliest manifestations were irritability and sinus tachycardia which alleviated after starting digoxin and at the end of the 2nd exchange transfusion. Other reported adverse effects were myelosuppression, weakness of extremities, diminished deep tendon reflexes and ileus which resolved at the time of discharge from hospital on day 13 of admission. It is speculated that exchange transfusion is an effective modality in reducing the serious adverse effects of VBL overdose.}, Keywords = {Vinblastin, Overdose, Exchange Transfusion}, volume = {5}, Number = {2}, pages = {113-115}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-205-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-205-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Zareifar, S and Shorafa, S and Haghpanah, S and Karamizadeh, Z and Adelian, R}, title = {Association of serum leptin level with obesity in children with acute lymphoblastic leukemia}, abstract ={Background Obesity is a medical problem in survivors of childhood acute lymphoblastic leukemia. Obesity is associated with many complications, so it is important to investigate the respective etiology. Leptin is a protein synthesized in the fatty tissue and is effective in the control of obesity. Survey of leptin in acute lymphoblastic leukemia (ALL) survivors could be helpful in controlling obesity. Materials and Methods In this prospective study, 53 pediatric patients diagnosed with ALL between 2006 and 2012 from Southern Iran, were enrolled. We examined body mass index (BMI) status and performed laboratory measuring tests including triglyceride, cholesterol, fasting blood sugar, leptin at diagnosis time and then every 6 months and in the last visit. Results patients. At the time of diagnosis, 5.66% were overweight or obese, whereas at the end of treatment, approximately 13 patients (24.53%) were overweight or obese. The median and interquartile range (IQR) for blood leptin level were significantly higher for obese patients than other patients (885, 1120 vs. 246, 494 pg/ml), (P=0.030). The median and IQR were also significantly higher in females than in males (861, 969 vs. 204, 267 pg/ml), (P=0.006). Conclusion Obesity is a complication of ALL treatment. It is associated with elevated blood leptin level. Hypothalamus leptin resistance in obese patients should be considered. In each visit, clinicians should weight and their patient’s BMI take into account.}, Keywords = {Acute Lymphoblastic Leukemia, BMI, Leptin, Obesity}, volume = {5}, Number = {3}, pages = {116-124}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-212-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-212-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Mirzadeh, M and Mirzaei, M and Mirzaei, M and ShogaeiFar, H}, title = {Years of Life Lost and Childhood and Adolescent Cancer Mortality in Yazd Province, Iran (2004-2009)}, abstract ={BackgroundThe Years of Life Lost (YLL) due to cancer can be a more illustrative index. to promote preventive and therapeutic services, this study aimed to investigate the childhood cancer mortality and its trend over the past few years in Yazd to provide planners with baseline data. Material and Method Data obtained from death registration system of the healthcare center were used to calculate the age-specific standardized mortality for 5-year age groups. To calculate the YLL, the standardized expected YLL method was used with a discount rate of 0.03 for health gain in the future, the age weight of 0.04 for different years of age, and a constant age weight correction factor of 0.165. The collected data were analyzed using the Epi 6 and Excel 2007. Results 28 patients in Yazd aged 0-19 die annually due to cancer (male/female ratio 1.34). Leukemia and CNS tumors were the most common causes of death.The crude cancer death rate is 8.48 in boys and 6.72 in girls per 100000. Premature cancer deaths have caused 3,436 YLL in boys and 2,561 YLL in girls (4.92% of total YLL in both sex) .The average death age did not have a significant relationship with sex, location of residence. Conclusion Childhood cancer mortality has had a decreasing trend. This study can help in the assessment of healthcare needs and improvement of the quality of healthcare services. It can also help in the design and prioritization of interventions to identify cancer risk factors which can facilitate early diagnosis.}, Keywords = {Years of Life Lost, Cancer, Mortality, Childhood, Iran}, volume = {5}, Number = {3}, pages = {125-130}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-213-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-213-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {MahmoudiNe, H}, title = {Comparison effect of Midazolam alone and Midazolam combined with Ketamine in bone marrow aspiration pain in children}, abstract ={Abstract Background This study aimed to compare sedative and analgesic effects of oral Midazolam and Ketamine on Bone Marrow aspiration (BMA) and Lumbar Puncture (LP). Material and Methods This study was a randomized clinical trial and was performed in Amirkola Hospital in north of Iran, Babol during 2011 and 2012 .The study population consisted of 40 patients who underwent the first time of diagnostic BMA for any reason, patients were divided randomly in two groups: Oral Midazolam and combined Oral Midazolam and Ketamine. Each group consisted of patients with age of 3-7 years and over 7 years .Two methods of pain status and soothing were evaluated through CAMFORT scale checklist based on MAGNUSON National Institutes of Health Medical Center. Statistical analyses were done by Spss v.19. Results In our study, 17(42.5%) and 23(57.5%) were female and male, respectively. 28(70%) patients were aged between 3 and 7 years and 13(30%) older than 7 years. The obtained findings revealed that the difference between Midazolam sedation and combination of Midazolam and Ketamine sedation was significant (P= 0.00). The sedation in older patients was more than young patients in combination of Midazolam and Ketamine group. (P= 0.22). Conclusion These findings showed that Ketamine and Midazolam combination had more efficacy than Midazolam alone for decreasing pain and sedation.}, Keywords = {Bone Marrow Aspiration, Lumbar Puncture, Ketamine, Midazolam}, volume = {5}, Number = {3}, pages = {131-137}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-214-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-214-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Boroumand, H and Moshki, M and Khajavi, A and Hashemizadeh, H}, title = {Mothers’ Satisfaction Rate from Hospital Cares in Hematology- Oncology Ward}, abstract ={Background Satisfaction evaluation is a good way to assess hospital conditions. In Health Care System, parentscan be also as children's main supporters, thus they may act as patient's viewpoints' representatives.This study aimed to evaluate mother’s satisfaction of hospital care in hematology – oncology ward in Dr Sheikh hospital. Materials and Methods A Cross-sectional descriptive analytic study was conducted using Pediatric Family Satisfaction (PFS) questionnaire and interviewing with 164 mothers duringMarchto February2013. The obtained data were analyzed using SPSS -16 software and descriptive statistics. Results The mean age of mothers and children was31.2±5.8, and 7.95 4/66 years.The children were 64 % male and 36 % femael. A large number of mothers (%56 (describedtheir satisfaction about medical care as moderate,(%70.7) reported their satisfaction about nursing care at very high level and(36.5 %) reported satisfaction about welfare services at high level(59%)and describe overall satisfaction at very high level . The totals mean of mothers’ satisfaction ratewas 121.8 ± 10.8. The mean of medical care, nursing care, welfare services was 2.9±34.1,4.6±50 and4.8± 32.9 respectively. Conclusion Overall satisfaction with medical, nursing and welfare staff was acceptable. For more satisfaction, it is widely recommended to improve veinipuncture by nurses, Physicians should inform parents about the tests results, and finally disturbance in ward with noise should be controled.}, Keywords = {Keywords Children, Hematology-Oncology Ward, Hospital Care, Mothers Satisfaction}, volume = {5}, Number = {3}, pages = {138-144}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-220-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-220-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Valizadeh, N and Noroozi, M and Hejazi, S and Nateghi, Sh and Hashemi, A}, title = {Seroprevalence of Hepatitis B, Hepatitis C and Human}, abstract ={Abstract Background Thalassemia patients that are conventionally treated by a regular transfusion regimen are exposed to blood born viral infections.The aim of this study was to investigate the seroprevalence of hepatitis B virus (HBV), hepatitis C virus (HCV) , and human Immunodeficiency virus(HIV) among all multitransfused thalassemia patients in west north of Iran. Material and methods A retrospective study was conducted in February 2014, on 32 patients in Urmia, suffering from transfusion dependent thalassemia were admitted to Motahari and Emam Khomeini hospitals. Patients’ medical records were studied for HBs antigen and seropositivity for HCV, and HIV antibodies. Results Out of 32transfusion dependent thalassemia patients aged between 5-17years, 18 (56.25%) and14 (43.75%) were male and female, respectively. All of them were found seronegative for HBs antigen, HCV, and HIV antibodies. Conclusion It seems that screening of blood products is efficient in Urmia , capital of West Azarbaijan, Iran for prevention of blood born viral infections.}, Keywords = {Antibody, HBs Antigen, HCV, HIV}, volume = {5}, Number = {3}, pages = {145-148}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-215-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-215-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Doosti, M and Vahedian-Ardakani, HA and Talebi, A and Akhavan-Ghalibaf, M and Najafi, A and Aminorroaya, MM and Yazdani, Sh and Shayestehpour, M}, title = {Serological Study on Cytomegalovirus and Toxoplasma Gondii in}, abstract ={Background Beta-thalassemia patients receive blood products from blood transfusion centers repeatedly. Blood transfusion can transmit Cytomegalovirus (CMV) and Toxoplasma gondii. The aim of this study was serological evaluation of these two infectious agents in thalassemia patients. Materials and Methods In a cross-sectional study, the enzymelinked immunosorbent assay (ELISA) testing was performed to detect IgM and IgG antibodies against CMV and Toxoplasma gondii in 96 thalassemia patients (under 18 years) and 144 healthy people. Data were analyzed by SPSS software and Chi-square test. Results A significant difference was observed in CMVIgM antibody levels between test group and control group in women (p<0.05). The prevalence of CMV IgM, CMV IgG, Toxo-IgG, and Toxo IgM antibodies in thalassemia patients were 5.2%, 95.9%, 16%, and 0%, respectively. Conclusions: In all thalassemia patients, Cytomegalovirus IgG is higher than healthy people. In addition, CMV IgM antibodies are higher in female patients. Antibody screening (IgM) on blood products for detecting Cytomegalovirus is necessary, but for Toxoplasma gondii is not necessary in the Yazd transfusion center. Conclusion In all thalassemia patients, Cytomegalovirus IgG is higher than healthy people. In addition, CMV IgM antibodies are higher in female patients. Antibody screening (IgM) on blood products for detecting Cytomegalovirus is necessary, but for Toxoplasma gondii is not necessary in the Yazd transfusion center.}, Keywords = {Beta-Thalassemia, Cytomegalovirus}, volume = {5}, Number = {3}, pages = {149-154}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-216-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-216-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Farhangi, Hamid and Badiei, Zahra and Ghasemi, Ali and Hesari, Sara and Banihashem, Abdollah}, title = {Comparison of anti-D immunoglobulin and dexamethasone in chronic and persistent forms of pediatric immune thrombocytopenic purpura}, abstract ={Bakcground: The aim of ITP treatment is to prevent intracranial hemorrhage and increase the platelet count rapidly. This study was conducted with the objective of comparing the efficacy of anti-D immunoglobulin (Ig) with dexamethasone in treating childhood ITP. Materials and Methods: In this randomized prospective control trial, 20 ITP patients (Platelet count<20,000/µl) younger than 16 were selected from those who referred to Dr. Sheikh Children Training and Research Hospital in Mashhad, Iran From February 2013 to January 2014. Patients were divided into two groups according to the type of administered treatment: group A received intravenous dexamethasone 40 mg/m2/ daily for four days. Group B received a single dose of intravenous anti-D Ig 50 µg/kg. The resultant data were then evaluated using SPSS (version 11.5). Results: In this study, 20 patients [11 girls (55%) and 9 boys (45%)] with the mean age of 5.6±4 years were enrolled. From the total number, 13 (65%) were younger than 5 years old, 4 (20%) aged between 5 and 10, and 3 (15%) were older than 10. There was no significant difference between the two groups regarding sex and age. In both groups the most common symptom was cutaneous manifestations (purpura, ecchymoses) (63.6% vs. 36.4% p=0.325). At enrolment time, the mean disease duration was 28±21 months, ranging from 5 to 132 months. Out of 20 patients, 9 (45%) suffered from chronic ITP, and 11 (55%) were in persistent phase of the disease. No significant difference was observed between the two groups regarding the frequency of chronic and persistent cases (p=0.370). Similarly, the follow-up platelet count four months after the treatment showed no significant difference between the two groups (p=0.241). Conclusion: The findings of this study did not confirm the priority of dexamethasone over anti-D Ig. The hemolytic side effects of anti-D were negligible compared to dexamethasone.}, Keywords = {Dexamethasone, Idiopathic, Purpura, RHO(D) antibody, Thrombocytopenic}, volume = {5}, Number = {3}, pages = {149-156}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-257-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-257-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Aliyari, Z and Alami, F and Mostafavi, T and TaiefiNasrabadi, H and Soleimanirad, J and NozadCharoudeh, H}, title = {The roles of IL-2, IL-7, and IL15 Ligands in B Cells development}, abstract ={Abstract Background B cells play an important role in the immune system due to production of the immunoglobulin and secreting several cytokines. It has been shown that B cells produced successfully in the presence of stem cell factor (SCF) and Flt3 ligand (Flt3L). IL2, IL7, and IL15 cytokines as -common family have an essential cytokines may support either synergistically or in an additive manner to B cell proliferative activity. Thus, the present study focused specifically on IL2, IL7, and IL15 cytokines that may play a critical role in B cell proliferation in cord blood. In this study, we evaluated the generation of B cells from CD34+/- cord blood mononuclear cells by using IL-2, IL- 7, and IL-15. Material and Methods Cord blood mononuclear cells were cultured for 21 days in presence of different combination of IL-2, IL-7, and IL-15. Harvested cells were analyzed by flow cytometry at days 0, 7, 14 and, 21. Results Present study showed that B cell differentiation from CD34+ cord blood mononuclear cells was increased by using IL-2 and IL-7 at different time points however, IL7 was more effective (P value < 0.0001). In contrast, IL-15 didn’t increase significantly B cell expansion from CD34+ cord blood mononuclear cell. Conclusion These findings showed that IL-2 and IL-7 significantly increased B cell generation from cord blood CD34+ cells probably this cytokines may be used in ex vivo generation of B cells from cord blood mononuclear cells.}, Keywords = {B cells, CD34+ cells, Cytokine, Umbilical}, volume = {5}, Number = {3}, pages = {155-160}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-217-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-217-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Mirbehbahani, Narges Beigom and SalamiKhanshan, Aysan and Safaian, Baranak and Mohammadian, Sakineh and behnampour, Nasser and Ariannejad, Safa and Masoomnia, Ali Reza and Malekmarzban, Azin and Rashidbaghan, Azam}, title = {Effect of Sodium Bicarbonate and Sodium Chloride on Renal and Hematologic Factors in Patients with Glucose-6-phosphate Dehydrogenase Deficiency}, abstract ={Background: Sodium bicarbonate serum therapy is used for compensation bicarbonate lost and increasing blood pH in metabolic acidosis caused by severe anemia in patient with glucose-6-phosphate dehydrogenase (G6PD) deficiency. The aim of present study was comparison the effect of serum therapy using two different serums (serum with bicarbonate and without bicarbonate) on some renal and hematologic factors and their side effects in patients with hemolysis caused by G6PD deficiency. Materials and Methods: In this clinical trial study, 79 patients with favism randomly put into two treatment groups, sodium bicarbonate and sodium chloride fluid therapy. During treatment, patients received blood based on hemoglobin (Hb). Duration of hospitalization, times of Blood transfusion, received blood volume, duration of cleaning UA of Hb, Hb, urine pH and granular casts in UA were evaluated. Results: The mean age of patients was 51.22 ± 37.86 months and there were 58 males and 21 females. Only duration of hospitalization and urine pH statistically showed a significant difference between two treatment groups (P=0.036 and P> 0.01, respectively), and other factors were statistically almost identical. Conclusion: The efficiency of sodium chloride was more than sodium bicarbonate in reducing the duration of hospitalization and the small clinical difference between received blood volumes, hemoglobin changes and duration of removing hemoglobin in UA, suggest, properly, sodium chloride can be more effective on improvement of hemolysis. Lack of side effects such as metabolic acidosis, heart damage and kidney failure in children can be due to controlled injection method, the concentration of soluble drugs and small size of studied population. }, Keywords = {G6PD, Favism, Hemolysis, Hemolytic Anemia, Sodium Bicarbonate}, volume = {5}, Number = {3}, pages = {157-165}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-259-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-259-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Hashemieh, M and TimoriNaghadeh, H and TabriziNamini, M and Neamatzadeh, H and HadipourDehshal, M}, title = {The Iran thalassemia prevention program: success or failure?}, abstract ={Abstract Background Iran is one of the countries located on the “thalassemia belt” and a thalassemia prevention program was approved in our country in 1995. Many different researchers have studied the success of this program with no unanimous findings. Material and Methods A comprehensive literature search was performed using PubMed, Web of Science, and Google Scholar databases in Farsi and English languages for relevant articles published up to March 2015. Results A total of 46 articles regarding thalassemia prevention were identified. After screening the titles and abstracts, 27 articles were excluded because they were the same articles, review articles, and case reports. Finally, 16 articles about the success of the Iranian thalassemia prevention program were selected for the evaluation. Conclusion The findings show that the program has been significantly successful in the reduction of the new thalassemia births, though not in a few provinces like Sistan and Baluchestan. The role of the network of genetic labs has been also indispensable in the reduction of the new births. However, there is ambiguity over the impact of the program on the attitude and awareness of people across the country about the prevention of inherited diseases. However, with the success of the Iran thalassemia prevention program, it needs to be modified to be more compatible with the relevant social textures of different provinces.}, Keywords = {Iran, Prevention Program, Thalassemia,}, volume = {5}, Number = {3}, pages = {161-166}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-218-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-218-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Goudarzipour, K and Jenabzadeh, A and MirzaeiIlali, H and Behnam, B and Tavassol, H}, title = {Solid Pseudo-Papillary Tumor of the Pancreas in a 10 year old girl}, abstract ={Abstract Background Solid pseudo-papillary tumor of the pancreas (SPTP) is a rare disease with a low malignant potential. Though it shows low malignant potential 10% to 15% of the cases show aggressive behavior with metastatic involvement of the liver. The symptoms include abdominal discomfort and abdominal pain. It is very rare in early years of age. This is the case of a 10 year old girl with abdominal pain and her evaluation revealed solid pseudo-papillary tumor of pancreas. In family history, her grandmother died because of pancreas cancer. The mass was excised and in her 6-month follow up she didn’t have any problems. This case is presented to point out physicians that more attention to pseudo- papillary tumor can bring us significant improvement in the diagnosis of this pathology, though pseudo- papillary tumor is a rare pathologic condition in children.}, Keywords = {Solid pseudo-papillary tumor of the pancreas}, volume = {5}, Number = {3}, pages = {167-169}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-219-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-219-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Eskandari, Fatemeh and Pourkarim, Hoda and Pakpour, Amir H and Goudarzi, Mehdi and Mobarra, Naser and Sahmani, Mehdi and Dehghanifard, Ali and Kalantari, Nasim and Gholamreza, Khamisipour and Azad, Mehdi}, title = {Gene Expression and Promoter Methylation Status of VHL, Runx-3, E-cadherin, P15 and P16 Genes During EPO-Mediated Erythroid Differentiation of CD34+ Hematopoietic Stem Cells}, abstract ={Background: VHL (von Hippel-Lindau), Runx-3 (Runt-related transcription factor 3), E-cadherin (Epithelial cadherin), P15 (INK4a, cyclin dependent kinase inhibitor), and P16 (INK4b) genes are essential in hematopoiesis. The aim of this study was to explore the correlation between gene expression and promoter methylation in CD34+ stem cells before and after differentiation to erythroid lineage. Materials and Methods: CD34+ hematopoietic stem cells were separated from umbilical cord blood using MidiMacs (positive selection) system. Expanded CD34+ stem cells were differentiated into erythroid lineage with human recombinant erythropoietin (EPO). DNA extraction was done by QIAamp DNA Mini Kit. RNA was extracted using RNase Mini plus Kit. MSP (Methylation specific PCR) technique was done for methylation assay. Methylation status and expression assay was done for VHL, Runx-3, E-cadherin, P15, and P16 genes  on both CD34+ stem cells and differentiated erythroid cells. Results: The results showed that, before differentiation, P15 had comparative methylation pattern and average expression and it remained unchanged after differentiation (p=0.01). concerning P16, results revealed no methylation pattern and complete expression in absence of EPO and with EPO it changed to comparative status (p=0.01). E-cad and Runx-3 genes had relative methylation pattern and fully expression before and after differentiation but their expression after that, was increased and decreased  Respectively (p=0.04). VHL gene had no significant methylation status before or after differentiation and its expression was complete (p=0.01). Conclusion: The obtained results indicated that promoter methylation of P15, P16, VHL, Runx3 and E-cad was one of the definitive expression control mechanism of these genes.}, Keywords = {Differentiation, EPO, Hematopoietic Stem Cells}, volume = {5}, Number = {3}, pages = {172-181}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-261-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-261-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {skandari, F and Allahverdi, A and Nasiri, H and Azad, M and Kalantari, N and Soleimani, M and Zare-Zardini, H}, title = {Nanofiber Expansion of Umbilical Cord Blood Hematopoietic Stem Cells}, abstract ={Background The aim of this study was the ex vivo expansion of Umbilical Cord Blood hematopoietic stem cells on biocompatible nanofiber scaffolds. Materials and Methods CD133+ hematopoietic stem cells were separated from umbilical cord blood using MidiMacs (positive selection) system by means of monocolonal antibody CD133 (microbeads) subsequently, flowcytometry method was done to assess the purity of separated cells. Isolated cells were cultured on plate (2 Dimensional) and fibronectin conjugated polyethersulfon nanofiber scaffold, simultaneously (3 Dimensional). Colony assay test was performed to show colonization ability of expanded cells. Results Cell count analysis revealed that expansion of hematopoietic stem cells in 2dimensional (2D) environment was greater than 3dimensional (3D) condition (p =0.01). Assessment of stem cell- phenotype after expansions was performed   by flowcytometric analysis which is showed that the maintenance of CD133 marker in expanded cells in 3 dimensional condition were higher than expanded cells in 2 dimensional condition (p=0.01). Moreover, colony assay test was performed before and after of  expansion to show colonization ability of expanded cells both in 3D and 2D culture and results revealed more ability of 3D culture compared with 2D culture (p =0.03). Conclusion The results of current study confirmed that umbilical cord blood CD133+ haematopoietic stem cells are able to expand on fibronectin conjugated polyethersulfon scaffold. These findings indicated that 3D is a proper and valuable cell culture system for hematopoietic stem cells expansion, compared to 2D in invitro situation.}, Keywords = {Umbilical cord blood, Polyethersulfon, Nanofiber scaffold}, volume = {5}, Number = {4}, pages = {170-178}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-223-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-223-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Ghasemi, A and Farhangi, H and Badiee, Z and Banihashem, A and Mosaddegh, MR}, title = {Evaluation of Nosocomial Infection in Patients at hematology-oncology ward of Dr. Sheikh children’s hospital}, abstract ={Background Infections in critical care unit are high, and they are serious hospital problems. Infections acquired during the hospital stay are generally called nosocomial infections, initially known as infections arising after 48 h of hospital admission. The mostfrequent nosocomial infections (urinary, respiratory, gastroenteritis and blood stream infection) were common in patients at hospital.The aim was to study, the current status of nosocomial infection, rate of infection among hospitalized children at hematology-oncology ward of Dr. Sheikh children’s hospital, Mashhad, Iran. Materials and Methods Data were collected from 200 patient;#39s records presented with symptoms of nosocomial infection at hematology-oncology ward of Dr. Sheikh children’s hospital from March 2014 to September 2014. Descriptive statistics using percentage was calculated. Results Incidence of nosocomial infections inpatients athematology-oncology ward was 31% (62/200). Of which 69.35% (43/62) blood stream infection being the most frequent followed by 30.64% (19/62) was urinary tract infection (UTI), and the most common blood culture isolate was been  Staphylococcus epidermidis 18 (41.86%), andour study showed that large numbers ofnosocomial UTIs causing by Gram‑negative bacteria. Conclusion This study showed blood stream infection and UTI are the common nosocomial infections among patients athematology-oncology ward. Early recognition of infections and short term use of invasive devices along with proper infection control procedures can significantly decrease the incidence of nosocomial infections in patients.}, Keywords = {Nosocomial Infection, Urinary, Respiratory, Blood Stream Infection }, volume = {5}, Number = {4}, pages = {179-185}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-227-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-227-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Mehrmohammadi, M}, title = {ABO and Rh Blood Type Relationship in Parents with more than One}, abstract ={Abstract Background Parental blood variables are one of the most important medical-biological causes of intellectual and physical-movement disabilities. The purpose of this study was to identify the relationship between parents’ blood variables (ABO and Rh blood type) and their relationship with frequency of intellectual and physical-movement disabilities in Isfahan province. Materials and Method This was a descriptive-analytical study and 494 samples were selected from mothers with more than one disabled child and mothers with normal child using simple and multistage random methods. The data collection was done through questionnaire. Based on Kuder-Richardson Formula 20 (KR-20), the reliability of questionnaire was 0.88. The statistical model in this study was a hierarchical log-linear method. Data were analyzed using SPSS version 16.   Results There was a significant relationship between mother’s Rh blood and having disabled child (P=0.002). However no significant relationship between having disabled children and the following variables was found: the father’s Rh blood (p=0.2), father and mother’s Rh blood together (P=0.5), father blood type (P=0.56), mother blood type (P=0.42), and mother and father blood types together (P=0.7). Conclusion Maternal and fetal blood incompatibility (motherwith negative Rh blood and fetus with positive Rh blood) increased the likelihood of being born with disabilities.}, Keywords = {Blood Type, Intellectual disability, Mental}, volume = {5}, Number = {4}, pages = {186-192}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-224-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-224-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {AdibHajbaghery, m and Ahmadi, m and Poormansouri, s}, title = {Health Related Quality of Life, Depression, Anxiety and Stress in}, abstract ={Abstract Background Awareness of factors associated with quality of life (QOL) in patients with beta-Thalassemia major (;beta-TM) is necessary to develop clinical programs in order to improve social support and QOL in ;beta-TM patients. This study aimed to examine QoL, depression, anxiety, and stress in ;beta-TM patients in Ahvaz, Iran. Materials and Method A cross-sectional study was conducted on173 ;beta-TM patients aged ;le12 years (12-18=55, ;le19=118). Subjects were selected using a census method. Data collection instrument consisted of three parts including: demographic questions, SF-36 questionnaire and depression, anxiety, and stress scale (DAS-21). Results The participants obtained a mean score of 64.38±18.20 for QOL, 6.4±5.1 for depression, 4.8±3.9 for anxiety, and 7.3±4.9 for stress. Significant relationship was found between QOL and employment (P=0.02) and education level (P<0.001). Patients in the age group of 12-18 years old had higher mean scores in the majority of QoL dimensions than those aged ;le19. The mean scores of depression, anxiety, and stress were higher in patients aged ;le19. No significant correlation was observed between QOL and depression, anxiety, stress scores, and other demographic variables. Moreover, a significant inverse correlation was found between QOL and depression (P<0.001,r= -0.62), anxiety (P<0.001,r= -0.55), and stress scores (P<0.001, r= -0.5) . Conclusion This study showed that ;beta-TM patients experienced a considerable decrease both in their overall QoL and in its dimensions. A majority of the ;beta-TM patients were also suffered from mild to severe depression, anxiety, and stress.}, Keywords = {}, volume = {5}, Number = {4}, pages = {193-205}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-225-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-225-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Valizadeh, N and Alinejad, V and Hejazi, S and Noroozi, M and Hashemi, A and Rahimi, B and Nateghi, Sh}, title = {Cardiac and Hepatic T2*-Weighted Magnetic Resonance Imaging}, abstract ={Abstract Background Iron overload is the main transfusion related side effects in patients with transfusion dependent hemoglobinopathies. Severe iron deposition in tissues leads to organ dysfunction. Many organs can be affected such as heart, liver, and endocrine organs. Cardiac failure and liver fibrosis are the consequent of Iron overload in transfusion dependent hemoglobinopathy. Magnetic Resonance Imaging (MRI) is a safe, noninvasive, and accurate method for the assessment of iron deposition in different tissues. This study assessed iron levels in liver and heart of the patients with transfusion dependent hemoglobinopathies. Materials and Methods The studied population consisted of 12 patients (7 male and 5 female) with transfusion dependent hemoglobinopathies, aged between 10-18 years old. Then, Cardiac and liver T2*-weighted magnetic resonance imaging (MRI) were obtained. Results In current study, 1patient (8.33%) had severe, 2 patients (16.66%) had moderate and 2(16.66%) had mild cardiac iron deposition. Out of 12 patients, 1 had severe iron deposition in liver (8.33%), 5(41.66%) and 4(33.33%) had moderate and mild hepatic iron deposition, respectively. Differences between Hepatic and cardiac iron levels were not significant between males and females (p>0.05). Conclusion Since cardiac and liver iron levels were higher than normal in most of the study group, checking ferritin level and liver function test and also echocardiography in shorter intervals (each 3 months) in involved group is suggested instead of checking routinely in 6 month intervals in patients with transfusion dependent hemoglobinopathies.}, Keywords = {Hemoglobinopathy, Heart, Iron, Liver,}, volume = {5}, Number = {4}, pages = {206-210}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-226-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-226-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {MoghaddamTabrizi, F and Barjasteh, S}, title = {Maternal Hemoglobin Levels during Pregnancy and their Association with Birth Weight of Neonates}, abstract ={Back ground Anemia in pregnancy is associated with increased rates of maternal and perinatal mortality, premature delivery, low birth weight, and other adverse outcomes Materials and Methods A prospective study was conducted on 1405 Iranian pregnant women who delivered during 2015. Blood was collected from all the subjects to measure the hemoglobin (Hb) during 16-19 weeks, 22-24 weeks, and 34-36 weeks of gestation. According to the level of hemoglobin, it is divided into 4 groups. Group 1 Hb > 10.1 gm/100ml (control group), Group 2 Hb= 8.1-10 gm/100ml (mild anemia) Group 3 Hb= 6.5-8 gm/100ml (moderate anemia) Group 4 Hb <6.5 gm/100ml (severe anemia). After delivery, the neonates were weighted within 24 hours after birth. Maternal hemoglobin and birth weights were compared. Results The anemia prevalence was 20.2% (Hb10 g/dl), considered  as normal gave birth to heavier and normal babies (3.3 kg). The severity of anemia during three trimesters was closely associated with birth weight of newborns. Conclusion The low hemoglobin values during three trimesters of pregnancy were associated with low birth weight in Iran. The anemia can lead to intra uterine growth retardation.}, Keywords = {Hemoglobin Level, Birth Weight, Pregnancy }, volume = {5}, Number = {4}, pages = {211-217}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-228-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-228-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Dalili, H and Baghersalimi, a and Dalili, s and Pakdaman, F and HassanzadehRad, A and AbbasiKakroodi, M and Rezvany, SM and Koohmanaei, Sh}, title = {Is there any relation between Duration of breastfeeding and anemia?}, abstract ={Background In the early months of life, Breastfeeding increases chance of survival, reduces recovery time after disease and mortality due to infections such as diarrhea and acute respiratory infections. However, infants who are exclusively breast-fed for more than 6 months in developing countries may be at increased risk of anemia. Therefore, the aim of study was to assess the relation between duration of breastfeeding and anemia. Materials and Methods In this analytical cross-sectional study, 400 neonates registered in primary health care system since birth time. Complete blood count and serum ferritin were obtained. Data were analyzed by chi- square test and regression analysis. P-value less than 0.05 was considered significant and 95% confidence interval was noted. Results Results of this study showed that 199 infants were anemic (Hemoglobin (Hb) concentration <11 mg/dl). Ten percent of anemic patients reported Ferritin< 12ng/dl and %25 of anemic children had iron deficiency anemia (IDA). In Binominal logistic regression, merely kind of delivery and duration of breastfeeding were effective factors. Binominal logistic regression also showed that natural vaginal delivery and exclusive breastfeeding up to 6 months had a significant influence on anemia. Exclusive breast feeding for 6 months or more increased the likelihood of anemia. In addition, 4 months exclusive breastfeeding decreased 0.686 fold the likelihood of anemia. Conclusion It seems that revision of health program recommendations for iron supplementation can be constructive. National planning to promote the level of knowledge regarding natural vaginal delivery and appropriate period for clamping can be recommended.}, Keywords = {Anemia, Breast Feeding, Ferritin , Iron-Deficiency}, volume = {5}, Number = {4}, pages = {218-226}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-229-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-229-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Zare-Zardini, H and Taheri-Kafrani, A and Amiri, A and Shanbedi, M and Sadri, Z and Ghanizadeh, F and Neamatzadeh, H and Sheikhpour, R and KeyvaniBoroujeni, F and Daneshmand, F}, title = {Nanotechnology and Pediatric Cancer: Prevention, Diagnosis and Treatment}, abstract ={Despite development of new approaches for the treatment of cancer disease, it is the second cause of mortality in world. Annually, 30000 persons die in Iran due to cancer diseases. Eighty percent of cancer patients are children which about 50% children lead to death. Given the high rate of cancer-related death, the new approaches for prevention, control, early diagnosis, and treatment of this disease seem necessary.  Investigation of new strategies is the major challenge for scientists at recent century. Nanotechnology as a new scientific field with novel and small compounds utilized different fields over the past ten years especially in medicine. This science has come to the forefront in the areas of medical diagnostics, imaging, and therapeutic scheduls. Therefore, it has the potential applications for cancer detection and therapy. This review will discuss the therapeutic applications of different nano-materials in diagnosis, imaging, and delivery of therapeutic agents for the treatment of cancer with a major focus on their applications for the treatment of cancer and cancer- related diseases in children. The advancements in established nanoparticle technologies such as liposomes, polymer micelles, and functionalization regarding tumor targeting and controlled release strategies as well as drug delivery were discussed. It will also review the blood toxicity of used nanostructures.}, Keywords = {Cancer, Children, Functionalization, Nanotechnology }, volume = {5}, Number = {4}, pages = {227-241}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-230-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-230-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {BoloukiMoghaddam, K and Zarkesh, M and Kamali, A and Dalili, S and Heidarzadeh, A and Hassanzadeh, A}, title = {The Association of Mean Platelet Volume with Intra Ventricular Hemorrhage and Broncho Pulmonary Dysplasia in Preterm Infants}, abstract ={Background Interventricular hemorrhage (IVH) and Broncho pulmonary dysplasia(BPD) commonly occur in premature infants and they associate with platelet dysfunction. The aim of this study was to investigate the association of MPV and occurrence of IVH and BPD. Materials and methods In this cross sectional study, 3 groups including IVH, BPD and control were compared. All participants were preterm neonates with <35 weeks of gestation. MPV was recorded during the first 48 hours of life for all cases. Data were reported by descriptive statistics and analyzed by Pearson correlation coefficient, spearman correlation coefficient, paired T test and multinomial regression analysis in SPSS version 17. Results Higher MPV level was noted in BPD and IVH groups versus control group (9.79±0.73 fl and 10±1.04 fl versus 8.33±0,91 fl p9 fl compared to controls (16.7%) (p<0.0001). Regression analysis showed that only MPV related to the occurrence of IVH (OR=2.200 95%CI p=0.013) and elevated MPV significantly increased duration of O2 therapy (p<0.0001) and mechanical ventilation (p=0.0010). Conclusion MPV value at first 48 hours of life can be noted as a simple biomarker for occurrence of BPD and specially IVH in preterm infants}, Keywords = {Bronchopulmonary dysplasia, Intraventricular hemorrhage, Mean platelet volume, preterm infants }, volume = {5}, Number = {4}, pages = {227-232}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-233-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-233-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} } @article{ author = {Zarepur, E and Moghimi, M}, title = {Trismus Resulting from Infantile Hemangioma of the Parotid: A Rare Case Report}, abstract ={by increasing number of vessels. Salivary gland tumors are uncommon and their overall incidence is about 3 per 100000 per year. Salivary gland hemangioma makes up 1 % of all salivary gland tumors. Trismus resulting from parotid hemangioma is so rare. The patient was a 6-month-old boy with a huge lesion in his right parotid who referred to Shahid sadoughi hospital of Yazd, Iran. The lesion appeared at 4 months of age and had rapid growth and was suspected as hemangioma after clinical examination and patient had trismus. The lesion was excised without any complications. Five months after surgery, area of the lesion appeared normal. Parotid hemangioma has low potential to turn into malignant form but early detection and biopsy are necessary for decreasing complications. Removal of the mass was the best treatment for the patients with large or complicated hemangioma however, it should be performed with caution because the tissues may bleed profusely. Patients may have long term survival after surgery.}, Keywords = {Parotid, hemangioma, trismus, vascular abnormality }, volume = {5}, Number = {4}, pages = {242-245}, publisher = {Shahid Sadoughi University of Medical Sciences, Yazd}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://ijpho.ssu.ac.ir/article-1-231-en.html}, eprint = {http://ijpho.ssu.ac.ir/article-1-231-en.pdf}, journal = {Iranian Journal of Pediatric Hematology and Oncology}, issn = {2008-8892}, eissn = {2228-6993}, year = {2015} }