Shahid Sadoughi University of Medical Sciences, Yazd
Iranian Journal of Pediatric Hematology and Oncology
2008-8892
1
1
2010
11
1
Environmental Risk Factors for Acute Leukemia and Non-Hodgkin Lymphoma in Children
1
3
EN
Seyed Jalil
Mirmohammadi
Azam sadat
Hashemi
Azadah
Souzani
khadijeh
Dehghani
Atef
Atefi
Zahra
Zareian Yazdi
Abstract
Objective
The incidence of childhood cancer has been increasing nearly one percent per year for the past two decades. Leukemia and lymphoma are the most common types of childhood cancers. This study assessed the relation between environmental factors (Hydrocarbon, agricultural toxin, insecticide) and leukemia/lymphoma in children, which was evaluated by the frequency of the parents’ hazardous occupations, and their smoking, drug addiction, and alcoholism habits.
Methods
This was a case-control study on 86 children with leukemia and non-Hodgkin's lymphoma and 188 healthy controls from March 2007 till March 2010. They were matched in age and sex. Information was gathered via a questionnaire and analyzed by SPSS 15.
Result
There were 32 (37.2%) girls and 54 (62.8%) boys in the case group and the majority were 3-5 years old. In case group fathers’ occupations were mostly farmers 50 (58.1%), followed by painter or exposed to hydrocarbons 14 (16.6%), but in the control group, farmers were 17 (19.7%), and painters or those exposed to hydrocarbons were 5 (5.8%). The frequency of fathers' various occupations was significantly different between cases and controls. In addition, smoking, drug addiction and alcoholism was significantly higher in cases fathers than controls fathers.
Conclusion
The frequency of leukemia and non-Hodgkin's lymphoma in children whose father were painters, exposed to hydrocarbons and farmers are higher than normal children. So people with these occupations should pay more attention and should be protected against these risk factors. The history of addiction and alcoholism was higher in their father.
Shahid Sadoughi University of Medical Sciences, Yazd
Iranian Journal of Pediatric Hematology and Oncology
2008-8892
1
1
2010
11
1
Efficacy of Chicory in Decreasing Serum Ferritin and Liver Enzymes in Major Beta Thalassemia Patients
4
7
EN
Najme
Shahvazian
Azam sadat
Hashemi
Mehrdad
Shakiba
Mohammad Hosein
Farahzadi
Fatemeh
Mahmoodabadi
Abstract
Objective
Thalassemia major is a severe transfusion-dependent anemia that needs iron chalation therapy to remove iron overload. The objectives of the present study were to assess the iron overload liver response to inulin of chicory supplementation by evaluating the serum ferritin and liver enzymes.
Methods
Among 70 beta thalassemia patients, 50 were selected for chelating therapy using inulin of chicory. The initial dose was 1gr given twice a day. Twenty patients were excluded because of Hepatitis B and C and cardiac heart failure.
Results
From 50 patients, 47 patients tolerated chicory, which the majority showed dramatic responses. Mean serum ferritin level decreased from 3563.09 ng/ml to 1728.54 ng/ml. Mean serum AST level decreased from 25.44 u/lit to 22.25 u/lit. Mean serum ALT level decreased from 30 .861u/lit to 25.085u/iit. Serum ferritin level decreased significantly after treatment (PV≈ 0.00), but there was no significant difference in AST (PV=0.379) and Alt (0.367) after chicory treatment.
Conclusion
The present results suggest that chicory can reduce iron over load and liver enzymes. Significant differences in serum ferritin were found during intervention, but not in LFT enzymes.
Shahid Sadoughi University of Medical Sciences, Yazd
Iranian Journal of Pediatric Hematology and Oncology
2008-8892
1
1
2010
11
1
Oral Ciprofloxacin Compared with Intravenous Ceftazidim on Low Risk Febrile Neutropenia in Acute Lymphocytic Leukemia
8
13
EN
azam Sadat
Hashemi
Neda
Najafi
Fatemeh
Behnaz
Asghar
Zare
Abstract
Objective
Fever and neutropenia are a common complication of chemotherapy in cancer. It is usually managed by hospitalization and empiric administration of antibiotics. Use of Fluroquinolones is limited because of joint/cartilage toxicity. This study attempted to compare the efficacy of oral ciprofloxacin with intravenous ceftazidim in low risk febrile neutropenic lymphocytic leukemia.
Methods
Ninety two episodes of febrile neutropenia in 72 patients under 14 years old were studied prospectively for two years. All the patients received G-CSF plus intravenous ceftazidim 100 mg/kg/d and amikacin 15 mg/kg/d for 24 hours. These episodes randomly allocated into two groups. Group A received IV ceftazidim and amikacin for at least 3 days. After discharge they got oral cefixim 8 mg/kg daily. Group B discharged and received oral ciprofloxacin (20 mg/kg.day) for seven days. Failure was defined as temperature higher than 38 °C for more than 72 hours or major complication.
Results
Failure of intravenous ceftazidim plus amikasin for at least 4 days in hospital, in low risk febrile neutropenic children, was 6.5%, but failure of oral ciprofloxacin for 7 days after 24h intravenous ceftazidim plus amikasin was 4.3%. There was no arthrotoxicity in patients received ciprofloxacin.
Conclusion
Empirical therapy with oral ciprofloxacin is safe and effective in children with leukemia and low risk FN.
Shahid Sadoughi University of Medical Sciences, Yazd
Iranian Journal of Pediatric Hematology and Oncology
2008-8892
1
1
2010
11
1
Sequential Deferoxamine - Deferasirox in Treatment of Major Thalassemia with Iron Overload
14
18
EN
Bijan
Keikhaei
Abstract
Background
Iron overload is a major problem in patients with major thalassemia. An effective and safe iron chelator protocol with high compliance rate plays an important role in treatment of these patients. This study was done to assess the efficacy and safety of the sequential deferoxamine and deferasirox protocol in major thalassemia patients in Khuzestan province, Iran.
Material and Method
Sixty two patients were studied aged between 2 to 30 years old. A regimen consisted of 4 days deferasirox followed by 3 days deferoxamine. The duration of trial was 6 months. The efficacy was determined by comparison of ferritin level before and after treatment.
Results
Serum ferritin changed from 3590 ng/ml to 2563 ng /ml, which decreased significantly. During study 21% of patients experienced at least one side effect.
Conclusion
This is a new regimen with high efficacy, low toxicity and acceptable compliance.
Shahid Sadoughi University of Medical Sciences, Yazd
Iranian Journal of Pediatric Hematology and Oncology
2008-8892
1
1
2010
11
1
Frequency of Tumor Lysis Syndrome in Aggressive and Slow Introduction Chemotherapy in Children with ALL
19
23
EN
Azam Sadat
Hashemi
Najme
Shahvazian
Asghar
Zarezade
Mehrdad
Shakiba
Atef
Atefi
Abstract
Background
Tumor Lysis Syndrome (TLS) is an oncologic emergency that results from massive lysis of malignant cells. The incidence of TLS depends on the risk factors, such as baseline hyperuricemia, bulky tumor burden, elevated serum LDH, and elevated WBC. The objectives of the present study were to assess frequency of Tumor Lysis Syndrom in children with ALL in two methods of induction chemotherapy, aggressive and slow induction.
Materials and Methods
In this double blind randomized interventional study, the number of 60 ALL patients in the Shahid Sadoughi Hospital Yazd were studied. They randomly treated using two various methods 30 patients by invasive and 30 by slow induction chemotherapy.
Results
From 60 patients, 10 cases (16.6%) developed Tumor lysis syndrome. Seven of 10 treated by aggressive chemotherapy and remaining 3 by slow chemotherapy. No significant differences were found (PV= 0.166) between them.
Conclusion
Based on this study there was no significant difference between Tumor Lysis Syndrom in aggressive induction chemotherapy and slow induction, but WBC and LDH levels before treatment can predict Tumor Lysis Syndrom.
Shahid Sadoughi University of Medical Sciences, Yazd
Iranian Journal of Pediatric Hematology and Oncology
2008-8892
1
1
2010
11
1
An Epidemiologic Study of Ewing Sarcoma Family at SHAFA Hospital in Khozestan Province-IRAN, a Referral Children Cancer Treatment Center
24
26
EN
Ali
Ghasemi
Ataallah
Hiradfar
Mohammad
Pedram
ABSTRACT
Background
Ewing Sarcoma is the second most frequent primary bone cancer, following Osteosarcoma in children. These tumors consist of small, round, or oval cells, which are believed to derive from parasympathetic autonomic nervous system. The common clinical presentations are pain, local tenderness, fever, palpable mass, and pathologic fractures.
Methods and Materials
This study describes 47 children affected by Ewing Sarcoma registered since 1991 to 2007. All data were extracted from hospital admission notes and outpatient clinical records.
Results
Twenty seven patients were male and 20 were female. It is slightly more common in boys. Pain, Local tenderness, fever, and Pathologic fractures were common presentation. Majority of patients were between 10-15 years old.
Conclusion
Local tenderness, pain, and limping are important symptoms in children that should be check-up for immediate diagnosis and also proper management.
Shahid Sadoughi University of Medical Sciences, Yazd
Iranian Journal of Pediatric Hematology and Oncology
2008-8892
1
1
2010
11
1
Frequency of ABO and Rh Blood Groups in Middle School Students of Yazd Province
27
30
EN
Nasrin
Ghasemi
Jamshid
Ayatollahi
M
Zadehrahmani
A
Nasiri
A
Abedi
S
Shokraneh
M
Tahmasebi
Abstract
Objective
The history of the studies on blood groups dates back to early 20th century. More than 600 antigenic structures were detected among 29 blood groups. However, ABO and Rh antigenic structures were taken into consideration in transfusion medicine. Frequency of the blood groups in a community helps the individuals in need and blood bank employees, which could be related to some disorders.
Methods
This study aimed to find out the frequency of ABO and Rh blood groups in middle school students of Yazd province, which was done by evaluation of 2000 students between September 2006 and March 2007. Blood groups were examined by slide test method. Place and date of birth were answered by parents.
Results
The frequency of the blood groups B, O, A, AB were found in order as 30.6%, 30.4%, 27%, 12% respectively. Chi square test showed that is no significant relationship between ABO blood groups and sex, place of birth and insemination season.
Conclusion
This study confirmed that ABO and Rh antigenic structure differs between regions and nations.
Shahid Sadoughi University of Medical Sciences, Yazd
Iranian Journal of Pediatric Hematology and Oncology
2008-8892
1
1
2010
11
1
AN UNUSUAL PRESENTATION OF EXTRARENAL MALIGNANT RHABDOID TUMOR OF SOFT TISSUE: A CASE REPORT AND REVIEW OF THE LITERATURE
31
37
EN
Mohammad
Pedram
AtaAlah
Hiradfar
N
Karimian
Extra renal extra cranial malignant rhobdoid tumors (MRT) are rare, frequently lethal and affect mostly children. No definite treatment has been made and the role of radiation therapy is poorly defined.
This report explains a 14 year old girl with MRT in her neck soft tissue. She is alive with no evidence of disease 18 months after diagnosis. Through the experience with this case, we suggested that radiation therapy is not beneficial enough in all MRT cases and an aggressive multimodality approach should be chosen according to the stage and the state of its respectability.