2024-03-28T21:49:15+03:30 http://ijpho.ssu.ac.ir/browse.php?mag_id=12&slc_lang=en&sid=1
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Iranian Journal of Pediatric Hematology and Oncology Iran J Ped Hematol Oncol 2008-8892 2228-6993 7 2013 3 3 Comparing Electrolytes in Prestorage Leukocyte-Reduced Packed Cell versus Unfiltered Packed Cell L Fallahi R Ghiliyan A Hashemi A Fatemi M Saeedi Abstract Background Blood transfusion is associated with side effects caused by residual leukocytes in blood and blood components. Using leukodepleted blood components can decrease some of these adverse effects. Among the various methods to remove leukocytes in blood components, prestorage leukoreduction has been most efficient, but the evidence of clinical side effects awaits further studies. We evaluated changes of electrolytes in prestorage leukocyte-reduced red blood cells. Materials and Methods In this case-control study, one hundred twenty eight packed cells were studied: 64 unfiltered packed cells and 64 prestorage filtered packed cell. Two groups were matched as sex and age. Electrolytes such as Calcium, Sodium, and Potassium of two groups were measured, and compared during preparation. Results In this study, mean of Calcium in unfiltered and filtered group were 6.16±1.09 mg/dl and 5.57±2.21 mg/dl, respectively (P-value<0.055). Mean of Sodium in unfiltered group also was 155.91+/-9.51meq/l and in filtered group, 153.05+/-13.21meq/l (P-value<0.163), and mean of Potassium in unfiltered group was 5.01+/-1.72 meq/l and in filtered group, 7.42+/-2.45meq/l (P-value<0.001). Conclusion Releasing of Potassium during preparation of prestorage leukoreduction can cause increased Potassium level and hemoglobin concentration changes in prestorage filtered packed cell. Electrolytes; Blood Transfusion; Leukocytes 2013 9 01 86 90
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Iranian Journal of Pediatric Hematology and Oncology Iran J Ped Hematol Oncol 2008-8892 2228-6993 7 2013 3 3 Five-Year Status of Malaria (a Disease Causing Anemia) in Yazd, 2008-2012 A Fattahi Bafghi S A Pourmazar F Shamsi Abstract Background Yazd province which is the host of local and foreign immigrants may be faced with contacting malaria. Plasmodium falciparum malaria remains a major cause of mortality throughout in the tropical regions of the world. Pthophysiologic mechanisms of anemia in malaria is such as direct invasion of Red cells, anemia of chronic disease hypersplenism, Hemophagocytic syndrome and erythrophagocytosis, dyserythropoirsis, immune haemolysis and cytokine deregulation anemia of chronic disorder is characterized by moderate to mild normocytic, normochromic anemia along with microcytic hypochromic cells. Malaria occurs predominantly in children in the first three years of life. The purpose of this study was Demographic study of malaria during 2008 to 2012 in Yazd. Materials and Methods This study was an analytic-descriptive and manner descriptive study. All episodes (Imported Malaria) of disease from 2008 to 2012 which were documented in Yazd Central Health Service were carefully studied and reported. Results A total of 206 confirmed reported malaria patients from 2008 to 2012 were studied Plasmodium (P).vivax species was mostly, 187(90.78%) and Plasmodium (P). Malaria species was Lesley, 1(0.49%). The mean age groups, accommodation with local malaria and years of reported outbreaks of different strains of the parasite conducted by Fisher exact Test, showed no significant difference(P-value>0.05), but the mean of foreigner immigrants of outbreaks of different strains of the parasite conducted by Fisher exact Test, showed significant difference (P-value=0.01). Conclusion Although malaria has been designed on elimination program in Iran, but in the province of Yazd is reported imported malaria and its importance in causing anemia and other blood disorders is not negligible. Malaria; Anemia; Plasmodium falciparum; Iran 2013 9 01 91 96
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Iranian Journal of Pediatric Hematology and Oncology Iran J Ped Hematol Oncol 2008-8892 2228-6993 7 2013 3 3 Methylene Blue Based Device for Pathogen Reduction in Human Plasma A Elikaei S M Hosseini Z Sharifi H Latifi H Nikbakht H Mirshafiee A Asadollahi Abstract Background Despite improvement in safety of plasma transfusion some virus transmission still remains a problem. So as World Health Organization (WHO) recommends, many countries developed Pathogen Reduction Technologies (PRT) to inactivate pathogens, in plasma components. The Methylene Blue (MB) based methods is one of the most universal one. The purpose of this research was, produce a device that can inactivate viruses in MB environment. Materials and Methods In this interventional study, each Plasma Sample was illuminated by 70Pieces (PCs) of 1 w red Light Emitting Diodes (LEDs) from one side. These LEDs emit light at central wavelength of 627 nm with 20 nm Full Width at Half Maximum (FWHM). Two model viruses Herpes Simplex Virus (HSV) and Vesicular Stomatitis Virus (VSV) were used and Tissue Culture 50% Infection Dose (TCID50) was used to calculate virus Log reduction. Two concentration of MB and 5 different illumination times were used. Results In 10 µm concentration of MB, HSV had 6.00±0.2 maximum log reduction that obtain after 60 minutes illumination and VSV had 5.50±0.3 maximum log reduction after 75 minutes illumination. In 1 µM concentration of MB, HSV had 5.20±0.3 maximum log reduction that obtain after 60 minutes illumination and VSV had 4.90±0.2 maximum log reduction after 75 minutes illumination. Conclusion Results of virus inactivation in this method were similar to other methods (P-value0.05 in comparison with Theraflex), and it showed this device could inactivate viruses according to WHO recommendation. Blood-borne Pathogens;Plasma; Methylene Blue 2013 9 01 97 102
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Iranian Journal of Pediatric Hematology and Oncology Iran J Ped Hematol Oncol 2008-8892 2228-6993 7 2013 3 3 Comparing the Efficacy of Ceftazidime and Meropenem in Treatment of Febrile Neutropenia in Pediatric Patients with Cancer F Ferdosian R Ghiliyan A Hashemi B Akhondzadeh E Gholampoor Abstract Background In cancer patients, various infections were developed due to severe neutropenia resulted from chemotherapy. Ceftazidime is commonly used as monotherapy of cancer patients with fever and neutropenia. Meropenem is a new carbapenem with more extended antibacterial spectrum including anaerobes. It provides better coverage against gram positives. This trial compared the efficacy and safety of meropenem with ceftazidime as empirical monotherapy for febrile neutropenia in pediatric patients with cancer. Materials and Methods A prospective, double-blind, randomized clinical trial was conducted at Departments of Pediatric Haematology/Oncology, University Hospitals, Yazd, Iran, during the years 2012 to 2013. A total of 48 cancer patients participated in the trial. Result In this study, 26 patients (54.16%) were treated by ceftazidime and 22 patients (45.84%) by meropenem. Mean duration of fever in those who responded to treatment in ceftazidime group was 19.43+/-31.04 hours, and in meropenem group was 16.53+/-28.77 hours (P-value =0.965) Conclusion Finding of this study indicate that ceftazidime and meropenem have similar efficacy in treatment of fever and sever neutropenia. Due to more availability and lower cost of ceftazidime than meropenem, ceftazidime is suggested as a first line treatment in fever and neutropenia. Ceftazidime; Meropenem; Pediatrics 2013 9 01 103 107
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Iranian Journal of Pediatric Hematology and Oncology Iran J Ped Hematol Oncol 2008-8892 2228-6993 7 2013 3 3 Quality of Life in Children with Β-Thalassemia Major at Center for Special Diseases S Kaheni M Yaghobian G H Sharefzadah A Vahidi H Ghorbani A Abderahemi Abstract Background Knowledge of factors associated with quality of life in patients with thalassemia is necessary for creating appropriate clinical programs, social support, and improving treatment outcomes. The purpose of this study was to determine quality of life in children with thalassemia major at Center for Special Diseases of valiasr hospital in Birjand. Materials and Methods This cross-sectional descriptive-analytical study was conducted on 40 children over 7 years of age with thalassemia major. Tools for data collection included a demographic questionnaire and World Health Organization Quality of Life questionnaire (WHOQOL- Bref) standard questionnaire comprising 26 items to determine quality of life in patients with thalassemia. Data was analyzed using descriptive statistical tests (mean, SD, and frequency), and inferential statistical test (t-test) in SPSS software. Results Results showed mean score of 70.37±9.88 for quality of life, 25±3.06 for physical health, 18.12±3.22 for mental health, 21.3±4.43 for living environment, and 5.95±1.58 for sociability. Quality of life of the patient was above average in three dimensions of physical health, psychological health, and environmental health. However, in social relationship dimension, quality of life was less than average. There was no significant correlation between quality of life and demographic variables. Correlation between social relationships and education level was significant (P-value<0.0001). Conclusion According to the results, quality of life of the patient was above average in three dimensions of physical health, psychological health, and environmental health, and in order to improve quality of life in these children, appropriate programs should be implemented to support them physically, mentally and socially, and improve patient’s relationship with Center for Special Diseases. Quality of Life; Child; Adolescent; Blood Transfusion 2013 9 01 108 113
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Iranian Journal of Pediatric Hematology and Oncology Iran J Ped Hematol Oncol 2008-8892 2228-6993 7 2013 3 3 Radiography Finding in the Jaws in Children Taking Bisphosphonate M Moeini M Moeini N Lotfizadeh M Alavi Abstract Background Bisphosphonates‎ inhibit osteoclasts, prevent bone resorption and decrease bone turnover. This study examined radiography finding in bisphosphonate-associated osteonecrosis of jaws. Materials and Methods This is a retrospective series of 12 clinically diagnosed patients between 7 to 21 year old (average 13 years). They required emergency dental conditions requiring management by dentist: non healing ‎extraction sockets and pain of bone exposure. The panoramic radiography and cone beam computed tomography was performed ‎to assess the problem. Thickening of the lamina dura was observed in 7 patients (58.3 %). But full-thickness sclerosis was seen in 6 patients (50 %). Sclerotic changes in the mandibular canal were noted in 3 patients (25 %). 5 patients (41.6 %) had poorly healing or non-healing of socket in extracted tooth and periapical lucencies. 4 people (33.3 %) had widening of periodontal ligament (PDL) space and osteolysis. Sequestra were seen in 3 persons (25 %). Finally in 2 children (16.6 %) were found oroantral fistula. Only one child (8.3 %) had thickening of soft tissue mid periosteal reaction. Results Most patients had some degree of osteosclerosis, especially in the area of alveolar bone. Thickening of the lamina dura was also seen in children. Other findings include: osteolysis, sequestra, periosteal new bone formation, widening of PDL,soft tissue thickening, non healing extraction sockets, oroantral fistula and periapical lucencies (P-value < 0.05). Conclusion Common radiographic features in patients taking bisphosphonate, was osteosclerosis. This sclerosis had different views that thickening of the lamina dura and alveolar crest were most common. Osteonecrosis; Jaw; Radiography; Thalassemia 2013 9 01 114 118
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Iranian Journal of Pediatric Hematology and Oncology Iran J Ped Hematol Oncol 2008-8892 2228-6993 7 2013 3 3 Seven Years Trends in Prevalence of Transfusion-Transmissible Viral Infections in Yazd blood Transfusion Organization H Javadzadeh Shahshahani M Vaziri F Mansouri Abstract Background Increasing blood supply safety is one of the most important goals of blood services in the world. In this study, we reviewed the prevalence rate and the trends of three main infections in whole blood donations and strategies for improving blood safety in Yazd blood transfusion center, Iran. Materials and Methods In this cross sectional study, data on hepatitis B, C and HIV infection were extracted from Iranian Donor Database of blood donation from 2004 to 2010 in Yazd province. All donors with positive confirmatory test were included. The data was analyzed by SPSS software due to demographic factors. Results The prevalence rate of hepatitis B, C and HIV infection decreased during these years (From 0.37%, 0.14% and 0 percent in 2004 to 0.14%, 0.05% and 0 in 2010, respectively). Both hepatitis B and C infections were significantly more in first-time blood donors with BSc or BA educational level. The prevalence rate of hepatitis B was significantly higher in donors with less than 20 year-old and female donors. The prevalence rate of hepatitis C was higherin30-39 age group (P-value=0.014). Conclusion The results showed that the strategies used for improving blood safety were efficient. Increasing public knowledge on blood-borne infections and their routes of transmission, importance of donating blood only by healthy donors are necessary to have a safe blood supply in future. Prevalence; HIV; HCV; Blood Donors; Iran 2013 9 01 119 124
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Iranian Journal of Pediatric Hematology and Oncology Iran J Ped Hematol Oncol 2008-8892 2228-6993 7 2013 3 3 Rituximab Is Indispensable for Pediatric Heart Transplant Recipients Developing Post transplant Lymphoproliferative Disorders R Karbasi-Afshar S Taheri Abstract Rituximab, an anti-CD20 agent, has been suggested as an effective strategy to deal with post transplant lymphoproliferative disorders (PTLD). In the current study, we aim to evaluate the efficacy of rituximab therapy in heart transplant population developing PTLD. A comprehensive search of the literature was performed to gather the available data on lymphoproliferative disorders occurring in heart transplant patients. Finally, data of 125 patients from 26 previously published studies were included into the study. Patients who underwent rituximab therapy had significantly worse tumoral histopathology features (P-value=0.003). Survival analyses showed no significant difference regarding receiving rituximab therapy for heart recipients however, when the analysis was repeated only including data of pediatric patients, significant beneficial effects for pediatric were found for rituximab therapy. In fact, no children undergoing rituximab therapy died during the follow up. In conclusion, this study showed that rituximab therapy in pediatric heart transplant recipients with PTLD represents surprisingly excellent results, making rituximab an indispensable agent in the management of the disease. To define feasibility of rituximab therapy in adult recipients of heart graft with PTLD, randomized controlled trials are needed. Pediatrics; Heart Transplantation; rituximab 2013 9 01 125 134
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Iranian Journal of Pediatric Hematology and Oncology Iran J Ped Hematol Oncol 2008-8892 2228-6993 7 2013 3 3 Infantile Fibrosarcoma in a Child: a Case Report A Hashemi S Tefagh A Seifadini M Moghimi Abstract Background Infantile Fibrosarcoma is a rare soft tissue tumor in infants and children mostly located in extremities. An infantile and adult form has similar histopathological patterns but survival prognosis is much better in infantile form. Recurrence of infantile fibrosarcoma is common but the rates of metastasis are less than 10 percent in children younger than five Years and 50 percent in children more than 10 years old. Case presentation In this case report, we presented a nine years girl with a relapsing mass in her left hand. The pathologic findings showed sheets of spindle-shaped cells with suggested diagnose of infantile fibrosarcoma. She was successfully treated with combination of surgery and chemotherapy with a good outcome. Conclusion Infantile fibrosarcoma is a differential diagnose of soft tissue mass in infants and children. It has a good prognosis and distant metastasis is uncommon. Choice of treatment is surgery but chemotherapy and radiotherapy were useful in decrease metastasis. Infant; Fibrosarcoma; Report 2013 9 01 135 137