2024-03-29T03:18:10+03:30
http://ijpho.ssu.ac.ir/browse.php?mag_id=15&slc_lang=en&sid=1
15-159
2024-03-29
10.1002
Iranian Journal of Pediatric Hematology and Oncology
Iran J Ped Hematol Oncol
2008-8892
2228-6993
7
2014
4
2
Logo therapy effect on anxiety and depression in mothers of children with cancer
H
Delavari
M
Nasirian
Baezegar bafrooei
K
Baezegar bafrooei
Background
Cancer diagnosis among children can cause high
stress and anxiety in parents, and they may lose their
life expectancy. The present study investigated the
effectiveness of Logo therapy on anxiety and
depression among mothers of children with cancer.
Materials and Methods
This study was conducted by a semi-pilot method
using pre-test and post-test with a control
experimental group. Therapy sessions were held
during 9 sessions of Logo therapy training for 90
minutes. The participants of this study were selected
among 30 mothers of children with cancer and using
sampling method in Yazd hospitals. The participants
divided randomly into two groups: experimental and
control. Participants in both experimental and control
group completed questionnaires on Beck Anxiety
Inventory and Beck Depression Inventory before and
after training.
Results
The results showed that the index of depression and
anxiety in control and experimental groups are 32.3,
6.63, 7.4 and 6.75, respectively. So, the level among
the experimental group has been decreased after
intervention of Logotherapy training and a significant
difference occurred in the pre-post test stages. The
results showed that Logo Therapy has a significant
effect in reducing anxiety and depression among
mothers of children with cancer (p<0.05).
Conclusion
Regarding the efficiency of this approach to reduce
anxiety and depression among mothers, this treatment
is recommended to be practiced beside other cancer
therapies, so they can practice the treatment process
with a better mood and mentality.
Logo Therapy
Depression
Anxiety
Children with Cancer
2014
6
01
42
47
http://ijpho.ssu.ac.ir/article-1-159-en.pdf
15-160
2024-03-29
10.1002
Iranian Journal of Pediatric Hematology and Oncology
Iran J Ped Hematol Oncol
2008-8892
2228-6993
7
2014
4
2
Frequency of Celiac Disease in Children with Beta Thalassemia major
N
Honar
S
Kamali
M
Karimi
karimim@sums.ac.ir
Background
We aimed to investigate the frequency of celiac
disease in children with β-thalassemia major (B-TM)
in Shiraz, southern Iran.
Materials and Methods
In this study, the prevalence of celiac disease in
children with B-TM was evaluated. Children with BTM
were screened for celiac disease by ant-tissue
transglutaminase (anti-tTG) IgA antibody, IgA level
and anti-tTG IgG. A total of 1500 school healthy
children in Shiraz with age/sex matched were
selected as control group.
Results
A total of 215 B-TM patients with mean age of 12.7
± 4.4 years, were included into the study (52.1% was
male). None of the patients were positive for anti-tTG
IgA. Eight cases were IgA deficient in whom antitTG
IgG was investigated but none of them were
positive for anti-tTG IgG. The finding in control
group has a seroprevalence of 2% and biopsy proven
disease of 0.6%.
Conclusion
Many patients with thalassemia major have multiple
non specific symptom that are not justifiable with
underlying disease and might be due to atypical
celiac disease. We didn't find any case of celiac
disease among more than 200 children with β-
thalassemia major in Shiraz, southern Iran. So it
seems reasonable to screen only those who have
features, even not classical, of celiac disease.
2014
6
01
48
52
http://ijpho.ssu.ac.ir/article-1-160-en.pdf
15-161
2024-03-29
10.1002
Iranian Journal of Pediatric Hematology and Oncology
Iran J Ped Hematol Oncol
2008-8892
2228-6993
7
2014
4
2
Medical expenses of patients with Favism admitted to 17th Shahrivar Hospital compared to G6PD enzyme screening cost, in north of Iran
B
Darbandi
darbandi45@gmail.com
M
Noghbaei
F
Mehrabian
M
Jafroodi
Background
Glucose-6-phosphate dehydrogenase (G6PD)
enzyme deficiency is one of the prevalent disorders in
Guilan province, northern Iran, causing many patients
to suffer from acute hemolysis. This disease has
imposed tremendous costs both on patients and
Health systems.
The aim of this study was to compare the direct costs
of favism treatment on patients and health system
with G6PD enzyme screening test.
Materials and Methods
In this descriptive prospective study, the medical and
hospital costs of acute hemolysis due to G6PD
deficiency were calculated and compared with the
expenses of screening newly born infants for this
disorder in Rasht. Data was collected by a
questionnaire.Student’s t-Test and chi-squared test
were recruited and data was analyzed using SPSS
ver. 20.
Results
In this study, 101 hospitalized patients with favism
(72 male and 29 female) admitted from October 2011
to the end of September 2012 were included. The
average cost of treatment for these patients was
approximately 726000000Rials (for each patient
7190000 Rials), which was about half of the cost of
screening for all newborn infants in Rasht during this
period.
Conclusion
The cost of G6PD enzyme screening in Rasht is
substantially lower than the cost of treating
hospitalized patients with Favism.
Favism
Cost of disease
Screening
G6PD
2014
6
01
53
56
http://ijpho.ssu.ac.ir/article-1-161-en.pdf
15-162
2024-03-29
10.1002
Iranian Journal of Pediatric Hematology and Oncology
Iran J Ped Hematol Oncol
2008-8892
2228-6993
7
2014
4
2
Quality of life in patients with thalassemia major
Sh
Ansari
A
Baghersalimi
baghersalimi498@yahoo.com.
A
Azarkeivan
M
Nojomi
A
Hassanzadeh Rad
Background
With modern medical management, thalassemia
major is now extending into adulthood and it is
expected to have a negative impact on the quality of
life (QOL) of the patients. The aim of this study was
to evaluate quality of life in patients with thalassemia
major.
Materials and Methods
This is an analytic case control study. Two hundred
and fifty patients and 51 participants as controls were
assessed using WHOQOL- BREF (Farsi version)
questionnaire. All questions were answered based on
the self-evaluated status in the past 2 weeks before
enrollment and were rated on a five-point Likert
scale. Therefore, the raw item score ranged from 1 to
5 and scaled in a positive direction and 6 dimensions
including overall QOL, overall health, physical,
psychological, social, and environmental relationship
were assessed.
Results
Results showed that the QOL in all 6 dimensions was
lower in patients compared to the controls (P<
0.05).Also age, higher education level, lower ferritin
level and using oral iron chelator were associated
with better QOL scores. On the other hand, cardiac
disease, hepatitis C and history of psychiatric
disorders were associated with impaired QOL scores.
Conclusion
These findings were important for future refinement
of national thalassemia program. So, we
recommended regular screening for psychiatric
disorders and facilitated access to oral iron chelators.
Regular monitoring and treatment of complications
especially cardiac disease and hepatitis along with
strict quality control of blood products were also
mandatory. Also, higher education of the patients
may improve quality of life.
Quality of life
Thalassemia Major
WHOQOLBREF
2014
6
01
57
63
http://ijpho.ssu.ac.ir/article-1-162-en.pdf
15-163
2024-03-29
10.1002
Iranian Journal of Pediatric Hematology and Oncology
Iran J Ped Hematol Oncol
2008-8892
2228-6993
7
2014
4
2
Seroprovalence of herpes simplex1, 2 IgG antibodies in patients with beta thalassemia in a major tertiary care hospital located in Yazd, Iran
A
Atefi
F
Binesh
binesh44@yahoo.com
A
Hashemi
A
Atefi
MM
Aminorroaya
Background
Patients with beta thalassemia suffer from increased
susceptibility to infections and putridity plays a major
role in the patient's morbidity and mortality. The risk
of transfusion-transmitted viral infection is well
known in these patients. However, there is dearth of
information about the seroprevalence of herpes
simplex virus (HSV) infection in patients with beta
thalassemia in literature. This study analyzes the
prevalence of anti-HSV1, 2 IgG antibodies in patients
with beta thalassemia in a major tertiary care hospital
located in Yazd,Iran.
Material and methods
In this case control study, we undertook a serological
study of HSV1,2 IgG antibodies among 45 patients
with beta thalassemia and 45 healthy individuals as
control group by ELISA method. A p.value <0.05
was considered statistically significant. Statistical
analyses were performed using SPSS.20.
Results
The prevalence of HSV 1,2 IgG antibodies were
estimated 88.8% among patients with beta
thalassemia and 77.7% in control group. Regarding
p.value=0.64, it showed no significant difference in
these two groups.
Conclusion
Although infectious diseases still represent a major
challenge in patients with beta thalassemia, HSV past
infection rate was not increased in these patients in
our study. More studies are required to clarify this
matter.
Thalassemia
Seroprevalence
Human herpes simplex virus
2014
6
01
64
67
http://ijpho.ssu.ac.ir/article-1-163-en.pdf
15-164
2024-03-29
10.1002
Iranian Journal of Pediatric Hematology and Oncology
Iran J Ped Hematol Oncol
2008-8892
2228-6993
7
2014
4
2
Bone density in transfusion dependent thalassemia patients in Urmia, Iran
N
Valizadeh
nsedaha0@gmail.com
F
Farrokhi
V
Alinejad
SM
Said Mardani
N
Valizadeh
S
Hejazi
M
Noroozi
Background
Patients with thalassemia major and intermedia are
susceptible to osteopenia and osteoporosis. The
mechanism of osteoporosis in these patients is
multifactorial. Transfusion related iron overload in
endocrine organs leads to impaired growth hormone
secretion, diabetes mellitus, hypothyroidism,
hypoparathyroidism, lack of sex steroids and vitamin
D deficiency that contribute to impairment in
achieving an adequate bone mass .The aim of this
study was assessment of frequency of bone loss in
patients with thalassemia major and intermedia in
Urmia City of West Azerbaijan, Iran
Materials and Methods
In this cross sectional descriptive study,10 patients
(lower than 18 y/o)with transfusion dependent
thalassemia attending to Motahari and Emam
Khomeini hospitals in Urmia city of Iran were
enrolled and scanned for Bone Mineral Density
(BMD) starting at around 10 years old.
Results
Tenatients (6 male and 4 female) with transfusion
dependent thalassemia (β-thalassemia major and
intermedia) aged 13to 17 years in Urmia city of Iran
were enrolled. Mean age of patients was
15.1±.37year old. Among them, 8 patients (80%)had
low BMD and2 of them (20%) had normal BMD in
lumbar spine. Only 30% of patients had low BMD in
the neck of femur.
Conclusion
We should perform annual BMD in patients with
thalassemia major and intermedia and hemoglobin H
disease in age of higher than 8 year old and treat low
BMD with administration of bisphosphonate, calcium
and vitamin D supplements. Medical consultation
with a rheumatologist and /or an endocrinologist
should be performed in these patients. Changing
lifestyle with mild daily exercise, adequate calcium
containing foods, avoiding heavy activities, stop
smoking, iron chelation therapy in adequate dosage,
early diagnosis and treatment of endocrine
insufficiency and regular blood transfusions can help
to achieve an optimal bone density in these patients.
Thalassemia
Bone mineral density
Osteoporosis
Bone Loss
2014
6
01
68
71
http://ijpho.ssu.ac.ir/article-1-164-en.pdf
15-165
2024-03-29
10.1002
Iranian Journal of Pediatric Hematology and Oncology
Iran J Ped Hematol Oncol
2008-8892
2228-6993
7
2014
4
2
Investigation on artificial blood or substitute blood replace the natural blood
Sh
Keyhanian
M
Ebrahimifard
m_ebrahimifard_21@yahoo.com
M
Zandi
Blood is a liquid tissue in which dissolved with
abundant chemical factors and millions of different
cells The reduction of unwanted side effects,
especially diseases that emerge through blood such as
HIV and hepatitis, has a significant role for modern
medicine of transfusion and transplantation. The
issues and costs of human blood collection and
storage, direct this procedure towards the use of
alternatives blood. Two important research fields of
this area were oxygen carriers based on hemoglobin
and perfluoro chemicals. While they do not have the
same quality as the blood cell products, the oxygen
carrier solutions have potential clinical and nonclinical
applications.
The result showed that these products can reach to
the body tissues easier than normal red blood cells,
and can control the oxygen directly. The final aim of
transfusion is to establish a transfusion system with
no side effects, and the fact that oxygen carrier
artificial blood has this property. The article attempts
to step towards solving some problems of blood
transfusion through describing the properties of
artificial blood alternatives
Hematology
Artificial Blood
Perfluor
Hemoglobin
Blood Transfusion
2014
6
01
72
77
http://ijpho.ssu.ac.ir/article-1-165-en.pdf
15-166
2024-03-29
10.1002
Iranian Journal of Pediatric Hematology and Oncology
Iran J Ped Hematol Oncol
2008-8892
2228-6993
7
2014
4
2
A Fetal Hemolytic Anemia in a Child with Cytomegalovirus Infection
S
Hosseeini
Sh
Ansari
E
Kalantar
M
Sabzechian
A
Alibeik
A
Dorgalaleh
dorgalaleha@gmail.com
Background
Autoimmune hemolytic anemia is a hematologic
disorder that is rarely observed in infants and young
children. Most of the cases are associated with viral
or bacterial infections. In some cases, AIHA can be
characterized by a chronic course and an
unsatisfactory control of hemolysis, thus requiring
prolonged immunosuppressive therapy.
Case report
Especially in children younger than 2 years of age,
the clinical course of the disease may show either
resistance to steroids or dependence on high-dose
steroids. We report here an infant fatal autoimmune
Conclusion
This case suggests that investigation for the presence
of CMV infection in infantile AIHA should be
considered. Severe hemolysis is rare but could be a
potentially life-threatening complication of CMV
infection described mostly in immune compromised
adults and children.
Autoimmune hemolytic anemia
Cytomegalovirus
Direct anti globulin test
Viral load
2014
6
01
78
83
http://ijpho.ssu.ac.ir/article-1-166-en.pdf