2024-03-29T12:32:07+03:30 http://ijpho.ssu.ac.ir/browse.php?mag_id=5&slc_lang=en&sid=1
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Iranian Journal of Pediatric Hematology and Oncology Iran J Ped Hematol Oncol 2008-8892 2228-6993 7 2012 2 1 Effectiveness of Permanent Implantable Catheter (Polysite) in Children with Cancer Hayedeh Hashemizadeh Haleh Borumand M Joodi M Hiradfar Abstract Background Totally implantable central venous access devices (ports) have been available for over 10 years, but have not been achieved widespread use in pediatric oncology patients. Ports facilitate the administration of chemotherapy in children with cancer. Materials and Methods In this study, early complications of implantable central venous access devices in children with different type of cancer was taken under investigation. All of the complications were recorded by staff nurses by checklist for one week. The study included 68 patients with different cancer (lymphoma-leukemia-sarcoma and wilms’ tumor) who were treated between April 2007 and November 2011 in oncology department of Dr Sheikh hospital, Mashhad University of medical science. Results Venous ports were placed in 26 (38.2%) girls and 42 (61.8%) boys aged between 2 and 12 years old (mean: 6 years).We implanted all of the venous ports in patients for chemotherapy, and port implantation procedures were performed by a experienced Pediatric Surgery. 3 cases (4.4%) have needle access site infections which were controlled with antibiotics. Catheter leakage in 3 cases (4.4%), port-catheter disconnection in 4(5.8%) cases and occlusion of the system in 5 cases (7.4%). In this period, there were no major complications. Conclusion With proper placement technique and adequate nursing care, they represent a definite improvement in child cancer therapy. Ports can provide satisfactory for the majority of pediatric oncology patients, with a low risk of line-related complications and a high degree of acceptability to children and their parents. Catheterization; Central Venous instrumentation adverse effects Child Neoplasms 2012 3 01 1 5 http://ijpho.ssu.ac.ir/article-1-52-en.pdf
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Iranian Journal of Pediatric Hematology and Oncology Iran J Ped Hematol Oncol 2008-8892 2228-6993 7 2012 2 1 The Accuracy of Ultrasonography in Compared with Computed Tomography in Detection of Anterior Mediastinal Neoplasms Azam Sadat Hashemi REZA Nafisi Moghadam ROZITA Ghilian SAHAR Shahbaz ATEFE Dehghani tafti Abstract Background The aim of this study was to evaluate sensitivity and specificity of mediastinal sonography, and compared with CT, in detection of anterior mediastinal neoplasms. Materials and Methods The sonography with convex probes (5.0 and 7.5 MHz) was done prospectively for 34 patients (from 2 to 25 years old) with mediastinal mass. The results were compared with the results of contrast computed tomogphy. Results Standard protocol of mediastinal ultrasonography showed a high diagnostic accuracy. In our study the sensitivity of ultrasonography in detection of anterior mediastinal adenopathies in compared with CT was 84.6% (CI95% 65.2-100). Its specificity, PPV and NPV were 90.5% (CI95% 77-100), 84.6% and 90.5%, respectively. Conclusion Trasonography may have a good role in detection of anterior mediastinal adenopathies, so that, it may be used to complement CT, and allowing a reduction of frequency of in patients. Sensitivity and Specificity Mediastinal Neoplasms Ultrasonography 2012 3 01 6 10 http://ijpho.ssu.ac.ir/article-1-53-en.pdf
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Iranian Journal of Pediatric Hematology and Oncology Iran J Ped Hematol Oncol 2008-8892 2228-6993 7 2012 2 1 Prevalence of Major Depressive and Anxiety Disorders in Hemophilic and Major Beta Thalassemic Patients Azam Sadat Hashemi Shahin Banaei-Boroujeni N Kokab Abstract Background The purpose of this study was to assess the prevalence of major depressive and anxiety disorders in hemophilic and major beta thalassemic patients related to education of their mothers as a family’s agent. Materials and Methods A case-control study was performed on 34 major beta thalassemic patients. For each patient the control group was selected and matched (with age and sex). Psychological data, including major depressive disorder and anxiety, were assessed by Beck and Ketel tests, respectively. Demographic data included age, sex and mother's educational level. Statistical analysis was performed by chi-square test, using the SPSS 13.0 software. Results A case-control study was performed on 34 major beta thalassemic patients with age 11-38 years old and 32 men hemophilic patients with age 12-55 years old. The prevalence of major depressive disorder and anxiety in thalassemic patients were more than control group, which were significantly further in patients with low level of mother's education. Overall in hemophilic patients, the psychological and demographic data revealed no difference with the control group (P>0.05). Conclusion This study indicated that the prevalence of major depressive disorder and anxiety were more in major beta-thalassemic patients and it was related with mother's education level, but prevalence of them in hemophilic patients was similar to normal population but further study is needed to confirm these novel observations. Anxiety Depressive Disorder; Major Hemophilia A Hemophilia B beta-thalassemia. 2012 3 01 11 16 http://ijpho.ssu.ac.ir/article-1-54-en.pdf
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Iranian Journal of Pediatric Hematology and Oncology Iran J Ped Hematol Oncol 2008-8892 2228-6993 7 2012 2 1 Hematologic Indices, Inflammatory Markers, Symptoms and Routine Diagnostic Tests in Childhood Brucellosis MB Khalili M Sadeh S Hekmati Moghaddam Abstract Background Brucellosis is endemic in Iran, and is seen in all age groups, including children. Its diagnosis in childhood needs a high index of suspicion. The diagnostic methods currently in use need evaluation for analytical performance. Objective The present study tries to evaluate the hematological indices, serologic markers of inflammation and symptoms in patients suspected of brucellosis. Furthermore, the results of three routine methods are compared: PCR, blood culture and Wright agglutination test. Methods Symptoms of patients were asked by questionnaire in 48 children. Hematological indices of the CBC test as well as results of CRP, ESR, blood culture, Wright test and PCR were also recorded. Analytical performance of those 3 tests was calculated. Results Nine out of 48 patients were positive for brucellosis by PCR, seven of which being positive for Wright test and 2 for culture. Fever and arthralgia were seen in 88.8% and 77.7% of PCR-positive cases, respectively. According to hematological findings 3 of PCR-positive patients (33.3%) had anemia and 2 (22.2%) showed leukopenia. Elevation of ESR was observed in 5 (55.5%), and CRP was positive in 7 such cases (77.7%). Conclusions Clinical symptoms, CBC parameters and laboratory markers of systemic inflammation cannot be considered reliable criteria for diagnosis of childhood brucellosis. We suggest usage of PCR rather than blood culture and Wright test for diagnosis in suspected pediatric cases, due to low sensitivity of both culture and Wright test. Brucellosis Children Diagnosis Polymerase Chain Reaction Culture 2012 3 01 17 21 http://ijpho.ssu.ac.ir/article-1-55-en.pdf
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Iranian Journal of Pediatric Hematology and Oncology Iran J Ped Hematol Oncol 2008-8892 2228-6993 7 2012 2 1 Determination of Relative Frequency of Mast Cells and Eosinophils in Gastric Mucosa Biopsies in Children with Recurrent Abdominal Pain and Normal Endoscopy Fariba Binesh Shide Osiya Rozita Ghiliyan A Kermanian Abstract Background Numerous disorders can cause recurrent abdominal pain. Many of these cases underwent endoscopy and clinician encounters patients with history of recurrent abdominal pain and normal endoscopy. We evaluated these biopsies with regard to their eosinophils and mast cell densities to find out a potential relationship between recurrent abdominal pain with eosinophils and mast cell densities in children. Materials and Methods This is a retrospective cross-sectional study. Fifty eight children with recurrent abdominal pain were evaluated following endoscopy. Two forceps biopsy was taken from each patient and then following routine histological evaluation, eosinophils and mast cells counts were performed. A questionnaire was filled for each patient, including clinical, endoscopic and pathologic findings. Data collected were statistically analyzed using SPSS, version 16. Results Fifty eight patients (31 girls and 27 boys) fulfilled the entrance criteria (ages7.19±3.1 years). The mean eosinophils density in 1-6 year-old group was more than 7-12 year-old group(3.52±4.67 vs 1.59±1.9)(p=0.04).The mean mast cells density in 7-12 year-old group was more than 1-6 year-old group(6.48±5.17 vs 3.9±3.14)(p=0.02). In boys the mean eosinophils density was higher than that of girls (3.56±5.07 vs 1.6±1.22) (p=0.05). With regard to microscopic findings, the greatest eosinophilic density belonged to normal histology (2.66±4.13). Conclusion Increased gastric eosinophils and mast cell densities are a common finding in children with abdominal pain and normal endoscopy. However, further studies are needed to determine the significance of eosinophils and mast cells activation in the disease process or symptom generation. Abdominal pain Endoscopy Eosinophils Basophils 2012 3 01 22 29 http://ijpho.ssu.ac.ir/article-1-56-en.pdf
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Iranian Journal of Pediatric Hematology and Oncology Iran J Ped Hematol Oncol 2008-8892 2228-6993 7 2012 2 1 Genetic Variations in Exon 3 of VWF Gene in Patients with Von Willebrand Disease (VWD) from South-West Iran Mahbubeh Nasiri H Galehdari M Darbouy M Yavarian B Keikhaee Abstract Background Von Willebrand disease (VWD) is an autosomally inherited bleeding disorder with the prevalence of 1% based on population studies. The disease phenotype is due to quantitative and structural/functional defects in Von Willebrand Factor (VWF) which is a glycoprotein with essential role as a carrier of FVIII in circulation and also it serves the function as hemostasis regulator. VWF is encoded by a large gene located on chromosome 12 which spans 178kb and has 52 exons. Many different mutations are known in VWF gene that can affect the VWD phenotypic features. Materials and Methods In this study we evaluated genetic variations in exon 45 of VWF gene in Iranian patients suffer from VWD from South-west Iran. Materials and Methods: 36 patients diagnosed with VWD (11 males and 25 females), with different ages, from Khuzestan province are participated in the investigation. Exon 3 with the flanking intronic sequences was amplified by PCR and the amplicons were analyzed by sequencing for any genetic changes (mutations and Single Nucleotide Polymorphism (SNPs)). Results No mutation was found in our patients in this exon . A novel SNP was recognized in all patients in a homozygous manner, T/C in intron 3. Conclusion Although previous molecular investigations of VWD in Iran and some neighboring countries documented several mutations in exon 3, our research showed some contradictory result. The results of our study provided a new insight for further studies, not integrating exon 3 in their analysis. von Willebrand Disease von Willebrand Factor Polymorphism ; Single Nucleotide 2012 3 01 30 34 http://ijpho.ssu.ac.ir/article-1-57-en.pdf
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Iranian Journal of Pediatric Hematology and Oncology Iran J Ped Hematol Oncol 2008-8892 2228-6993 7 2012 2 1 Epidemiology of Idiopathic Thrombocytopenic Purpura in Children SH Nazari F Abdollah Gorji MT Sadeghi-Koupai Abstract Background Immune thrombocytopenic purpura (ITP) is a common autoimmune bleeding condition in children that is characterized by a decrease in the platelet count. The aims of this study were to define epidemiologic features of patients with primary ITP who were admitted to Mofid Children's Hospital, Tehran, Iran, in a 5-year period. Methods We retrospectively studied the records of patients aged from 1 month to 13 years, who were admitted with the diagnosis of ITP at our hospital. Demographic and clinical variables such as platelet counts, prescribed medicine and transforming to chronic ITP were studied. Results One hundred and seventy two patients were eligible to enter this retrospective study. Mean age was 41.5 (from 1 to 160 months), which 98 were boys (57%) and 72 were girls. 130 (75.6%) and 42 (24.4%) patients had a platelet count less than 25000 and 10000/mm3, respectively. Younger patients significantly had a more severe sign (P=0.04). There was a significant relationship between younger age and chronic ITP (P<0.001. Chronic ITP significantly happened more frequent in girls than boys (P=0.01). Treatment did not have any significant influence on the time to remission, platelet level after one month, or change to chronic ITP. Conclusion This study showed that age Male gender increased the risk of severe disease while female gender was risk factors for transforming into chronic ITP. However, together with others reported from different centers in Iranian may provide a good overview of the epidemiology of ITP in Iran. Purpura Thrombocytopenic; Idiopathic Children Epidemiology Iran 2012 3 01 35 39 http://ijpho.ssu.ac.ir/article-1-58-en.pdf
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Iranian Journal of Pediatric Hematology and Oncology Iran J Ped Hematol Oncol 2008-8892 2228-6993 7 2012 2 1 Medullary Breast Carcinoma in a 17 Year- Old Female (Rare Case Report) SH Taghipour Zahir SM Shiryazdi MR Vahidfar Abstract Background Breast carcinoma is uncommon in women under 25 and very rare in less than 20 years old. Only few cases of infiltrating breast carcinoma have been reported and among them there was no report of medullary subtype. The purpose of this report is to determine clinical, histopathological and sonographic findings of large mass in breast of young female patient that diagnosed as medullary carcinoma. Case presentation A 17 year-old female with large mass in her right breast was referred to our clinic. In clinical examination the mass had a fleshy to firm consistency and the borders were not infiltrative. Ultrasonography findings were highly suggested for fibroadenoma. Histopathological examination demonstrated infiltrating breast carcinoma with medullary feature. Conclusion Although breast carcinoma is very rare in patients under twenty years old, in this age group a differential diagnosis with fibroadenoma should be considered. Carcinoma Ultrasonography Breast Fibroadenoma 2012 3 01 40 43 http://ijpho.ssu.ac.ir/article-1-59-en.pdf