Iranian journal of Pediatric Hematology and Oncology

en Clinicopathological Features, Prognostic Factors, and Survival Outcomes of Retroperitoneal Lesions عمومى General پژوهشي Research <div style="text-align: justify;">Background: Retroperitoneal tumors (RPTs) are rare and heterogeneous neoplasms that show distinct biological and clinical features across age groups. This study aimed to assess the clinicopathological characteristics of RPTs in pediatric and adult patients. Materials and Methods: This retrospective cohort study included patients diagnosed with RPTs from 2016 to 2021. The clinical data, histopathological findings, and outcomes were reviewed and compared between the children (< 18 years) and adults (≥ 18 years). Statistical analyses were performed using chi-square and Fisher’s exact tests, independent t-tests, Kaplan–Meier survival analysis, and Firth’s penalized logistic regression. Results: Among 109 patients, 14 (12.8%) were children and 95 (87.2%) were adults. Metastatic tumors were the most common lesion type (72.5%), followed by primary malignant (21.1%) and benign tumors (6.4%). Metastatic tumors were the predominant histopathological category (72.5%), followed by primary malignant mesenchymal tumors (16.5%). Histopathological distributions were similar between children and adults, with no significant differences observed across categories (all p>0.05). Overall survival was similar between children and adults (p=0.35). Abdominal pain was the most common symptom (51.4%), while nausea occurred more frequently in children (p=0.01). Firth’s penalized logistic regression identified no significant associations between clinicopathological factors and recurrence or necrosis (all p>0.05). Conclusion: Metastatic tumors predominated in both age groups, followed by primary malignant mesenchymal tumors. No significant age-related differences were observed in histopathological categories, tumor origin, or survival.</div> Histopathology, Metastasis, Retroperitoneal neoplasms, Survival rate 922 933 http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-1118-2&slc_lang=en&sid=1 MahmoodReza Roknaldini MahmoodReza Roknaldini roknaddinim@yahoo.com 0009-0003-9334-1743 No Faculty of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd. Iran Faculty of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran Maryam Vajihinejad Maryam Vajihinejad maryamvajihinejad@gmail.com 0000-0001-5682-5165 Yes Department of Pathology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran Department of Pathology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran