Volume 16, Issue 2 (3-2026)                   Iran J Ped Hematol Oncol 2026, 16(2): 893-899 | Back to browse issues page

Ethics code: IR.IUMS.FMD.REC.1404.336

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Bahoush G, Vafapour M, Rahimzadeh N. Normalization of Platelet Count after Romiplostim Treatment in a Patient with Thrombotic Thrombocytopenic Purpura: A Case Report. Iran J Ped Hematol Oncol 2026; 16 (2) :893-899
URL: http://ijpho.ssu.ac.ir/article-1-991-en.html
Normalization of Platelet Count after Romiplostim Treatment in a Patient with Thrombotic Thrombocytopenic Purpura: A Case Report
Gholamreza Bahoush * , Maryam Vafapour , Nahid Rahimzadeh
Pediatric Growth and Development Research Center, Department of Pediatrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.. & Pediatric Growth and Development Research Center, Department of Pediatrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Abstract:   (59 Views)
 Thrombotic Thrombocytopenic purpura (TTP) is the thrombotic microangiopathy (TMA) caused by the severely reduced activity of the von Willebrand factor-cleaving protease ADAMTS13. The deficiency occurs in two main forms, acquired (antibody-mediated) and inherited. Plasma exchange is the mainstay of the disease management; however, Caplacizumab, glucocorticoids, rituximab, and other immunosuppressive drugs may be added to the management protocol, particularly in refractory cases. Thrombopoietic drugs are a known therapy for idiopathic thrombocytopenia purpura (ITP). No studies have been reported so far on the effects of these drugs on the patients with TTP. In this case report, we report the treatment of a 17-year-old female with hereditary TTP and dramatically good response to romiplostim (Nplate) in a one-year follow-up without an increase in the ADAMTS13 level and thrombotic complications
Keywords: ADAMTS13 deficiency, Romiplostim, Immune Thrombocytopenic Purpura, Thrombotic Thrombocytopenic Purpura
     
Type of Study: case report | Subject: pediatrics
Received: 2025/09/23 | Accepted: 2025/12/22 | Published: 2026/03/30
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