Showing 13 results for Binesh
Fariba Binesh, Shide Osiya, Rozita Ghiliyan, A Kermanian,
Volume 2, Issue 1 (3-2012)
Abstract
Abstract
Background
Numerous disorders can cause recurrent abdominal pain. Many of these cases underwent endoscopy and clinician encounters patients with history of recurrent abdominal pain and normal endoscopy. We evaluated these biopsies with regard to their eosinophils and mast cell densities to find out a potential relationship between recurrent abdominal pain with eosinophils and mast cell densities in children.
Materials and Methods
This is a retrospective cross-sectional study. Fifty eight children with recurrent abdominal pain were evaluated following endoscopy. Two forceps biopsy was taken from each patient and then following routine histological evaluation, eosinophils and mast cells counts were performed. A questionnaire was filled for each patient, including clinical, endoscopic and pathologic findings. Data collected were statistically analyzed using SPSS, version 16.
Results
Fifty eight patients (31 girls and 27 boys) fulfilled the entrance criteria (ages7.19±3.1 years). The mean eosinophils density in 1-6 year-old group was more than 7-12 year-old group(3.52±4.67 vs 1.59±1.9)(p=0.04).The mean mast cells density in 7-12 year-old group was more than 1-6 year-old group(6.48±5.17 vs 3.9±3.14)(p=0.02). In boys the mean eosinophils density was higher than that of girls (3.56±5.07 vs 1.6±1.22) (p=0.05). With regard to microscopic findings, the greatest eosinophilic density belonged to normal histology (2.66±4.13).
Conclusion
Increased gastric eosinophils and mast cell densities are a common finding in children with abdominal pain and normal endoscopy. However, further studies are needed to determine the significance of eosinophils and mast cells activation in the disease process or symptom generation.
Md F Binesh , Md K Aghili , Md H Navabii , Md T Roushan ,
Volume 2, Issue 2 (6-2012)
Abstract
Abstract
Background
Histologically confirmed meningiomas in first year of life are quite rare. However, review of the sporadic cases in the literature reported meningioma in infants. Those have unique features in common.
Case presentation
An 11 month-old Iranian male infant presented with a several weeks history of decrease in movement of his right sided upper and lower extremities. Brain MRI revealed a large well-defined extra axial, Dural-based mass lesion, which is contained solid and cystic components. It is originated from falx, and showed intense contrast enhancement. The patient underwent a central craniotomy. The mass was removed sub totally. Microscopic examination of the specimen revealed a meningioma. Radiotherapy was deferred because of the young age. Patient follow up at 4 months later showed that the child was well.
Conclusion
Pediatric meningiomas show a higher frequency of cyst formation in compared with adult meningiomas. In addition, they show more frequent sarcomatous changes, which is male predominance. Absence of dural based attachment and higher incidence of intraventricular location were seen.
Md Sh Osiya , Md F Binesh , Md F Ferdosian, Md M Shakiba ,
Volume 2, Issue 4 (12-2012)
Abstract
Abstract
Background
Immune deficiency in human might be primary or secondary and could be seen with a wide variety of manifestations. In the following, we presented a Child with various complains that diagnosed to have HIV infection.
Case Report
A 2/5 y/o child was admitted to the hospital for FUO with prolonged cough, FTT, cervical lymphadenopathy, hepatosplenomegaly and bilateral optic neuritis. . He was hospitalized for fever, cytopenia and hepatosplenomegaly one year ago, and three months later in an outpatient visit, these signs improved, except thrombocytopenia. In evaluation, bicytopenia, elevated ESR, hyperlipidemia, hyperproteinemia, thrombosis of the transverse sinus of brain, antiphospholipid antibodies , decreased levels of protein S and factor V Leiden and increased level of anti thrombin III were detected. Consequently, the result of HIV antibody showed positive. In addition to warfarin and cotrimoxazole therapy, he was referred to special center for possible HARRT therapy.
Conclusion
In approach to patients with various clinical presentations such as cytopenia, recurrent or persistent lymphadenopathy, unexplained hyperproteinemia or hyperlipidemia, evaluation of HIV infection is highly recommended for consideration and further therapy.
F Binesh , A Yousefi , M Ordooei , Ma Bagherinasab ,
Volume 3, Issue 4 (12-2013)
Abstract
Background
Gaucher’s Disease (G.D.) is an autosomal recessive disorder resulting from the accumulation of glucocerebrosidase in the cells of macrophage-monocyte system as a result of a deficiency in lysosomal glucocerebrosidase. This enzyme is encoded by a gene on chromosome-1. Here we report a case of Gaucher’s Disease .G.D is rare in Yazd.
Case reports
We reported a patient that presented with weakness, pallor and gradually increasing abdominal girth. Clinical examination and history pointed to be a lipid storage disease. Final diagnosis of G.D. was reported
after examining the bone marrow smears. Confirmation of diagnosis on Gaucher’s disease was performed by measurement of glucocerebrosidase level.
Conclusion
We report a case of G.D. to emphasize the importance of early recognition by clinical manifestation and histological findings. G.D. should be considered in the differential diagnosis of children with unexplained splenomegaly.
Mr A Atefi, Dr F Binesh, Dr A Hashemi, Mrs A Atefi, Mr Mm Aminorroaya,
Volume 4, Issue 2 (6-2014)
Abstract
Background
Patients with beta thalassemia suffer from increased
susceptibility to infections and putridity plays a major
role in the patient's morbidity and mortality. The risk
of transfusion-transmitted viral infection is well
known in these patients. However, there is dearth of
information about the seroprevalence of herpes
simplex virus (HSV) infection in patients with beta
thalassemia in literature. This study analyzes the
prevalence of anti-HSV1, 2 IgG antibodies in patients
with beta thalassemia in a major tertiary care hospital
located in Yazd,Iran.
Material and methods
In this case control study, we undertook a serological
study of HSV1,2 IgG antibodies among 45 patients
with beta thalassemia and 45 healthy individuals as
control group by ELISA method. A p.value <0.05
was considered statistically significant. Statistical
analyses were performed using SPSS.20.
Results
The prevalence of HSV 1,2 IgG antibodies were
estimated 88.8% among patients with beta
thalassemia and 77.7% in control group. Regarding
p.value=0.64, it showed no significant difference in
these two groups.
Conclusion
Although infectious diseases still represent a major
challenge in patients with beta thalassemia, HSV past
infection rate was not increased in these patients in
our study. More studies are required to clarify this
matter.
Dr A Akhavan , Dr F Binesh , Dr A Hashemi , Dr H Shamshiri ,
Volume 4, Issue 3 (9-2014)
Abstract
Background
Ewing’s sarcoma family is a group of small round cells tumors. The aim of this study is to evaluate clinicopathologic characteristics and outcome of Ewing’s sarcoma in children and adolescents in Yazd, Iran.
Materials and Methods
All patients under 19 years with documented pathology of Ewing’s sarcoma family tumor who referred to Shahid Ramazanzadeh Radiotherapy center between 2002 to 2010 were enrolled in this retrospective study. Overall survival and disease free survival and prognostic factors were evaluated.
Results
Among approximately 80,000 patients who referred to Shahid Sadoughi pathology department, over an 8-year period, the total number of patients with Ewing sarcoma was 32, of which, 18 cases were under the age 19 . The mean age was 13.72 years. Five patients
(27.8%) had metastatic disease at the time of diagnosis. Complete response had been achieved in 8 (44.4%) of the patients. Local recurrence occurred in 4 (22.2%) of the patients. During the follow up 13 (72.2%) of the patients showed metastases. The mean overall survival was 34.79 months (95% CI: 22.27-47.32) .One, two, four and five year survival was 72%, 39%, 25% and 17% respectively. Complete remission occurred in 10 patients (63.6%). A trend of better overall survival was found in these patients (p=0. 55). When the brain and bone metastases occurred, the overall survival decreased significantly (p=0. 003 ).
Conclusions
The overall survival rate of Ewing's sarcoma is very low in comparison with other parts of the world.
Dr F Binesh, Dr A Hashemi, Dr M Vakili, Dr Mm Shakeri, Dr R Masoumi Dehshiri,
Volume 6, Issue 1 (3-2016)
Abstract
Abstract
Background
Data on childhood and adolescent malignant tumors incidence are skimp in developing countries. In this study, we analyzed the incidence and trend of childhood and adolescent cancers in Yazd city, center of Iran between Jan 2004 and Dec 2013.
Materials and Methods
The various types of malignant tumors were grouped pursuant to the International Classification for Cancer in Children. To
analyze the data, descriptive and illative statistical methods were used.
Results
Two hundred twenty-two patients with a malignancy aged less than 18 years were studied with a male to female ratio of
1.36.The mean age of patients was 9.88 (±5.7) years. Leukemia with the frequency of 84 (37.8%) and after that lymphoid
malignancies with the frequency of 49 (22.1%) were the most common cancers. There was a low range of oscillation in the
incidence rate of malignancies during this period of time (P value= 0.081). Malignancies were mostly in males (P value=0.057) but the whole process of malignancy incidence had gone toward the higher rate of incidence in females. Incidence rate of cancers types was steady. Malignancy incidence was 3-7 cases in hundred of thousands except a year of which this incidence rate was estimated 13.4.
Conclusion
Leukemias and lymphomas were the main cancers in the center of Iran. Childhood and adolescent malignancies may be
considerably under-recorded in our province .A childhood and adolescent cancer registry is necessary for exact analysis of these types of malignancies.
Dr Fariba Binesh , Dr Alireza Jenabzadeh , Dr Maryam Vagihinejad , Mr Mohammad Ali Dideban , Mrs Fatemeh Pourhosseini , Mrs Hadi Zare-Zardini ,
Volume 8, Issue 1 (1-2018)
Abstract
Malignant melanoma in children is rare. It can arise from congenital melanocytic nevi. In pediatric patients, diagnosis of melanoma is difficult and challenging because the physicians have a low index of suspicion. Marrow metastasis in malignant melanoma especially in children is extremely uncommon. Here, the authors reported a 5 year old girl who was presented with a 4 month history of pelvic and right lower limb pain and limping to the pediatric outpatient clinic in August 2016 at Shahid sadoughi Hospital,Yazd,Iran. She was febrile and had right cervical lymphadenopathy and scalp congenital nevus. The investigations confirmed the diagnosis of malignant melanoma with marrow and cervical lymph node metastases. The patient underwent multidisciplinary management and she was followed up closely.
Metastatic malignant melanoma is a rare and dangerous disease with poor prognosis in children. It should be considered in differential diagnosis of children with congenital melanocytic nevi.
Dr Fariba Binesh , Dr Adeleh Pakdelnia , Dr Sedigheh Vaziribozorg ,
Volume 8, Issue 3 (5-2018)
Abstract
Background: The brain and spinal cord tumors account for 15% to 20% of all childhood malignancies. It is important to know the epidemiologic characteristics and survival of these patients to better understand the disease and the factors affecting its prognosis. The aim pf this study was to characterize the clinicopathology and survival rate of childhood and adolescent brain and spinal cord tumors in center of Iran.
Materials and methods: This descriptive-analytic study was carried out using a retrospective cohort design. Thirty patients with brain and spinal cord tumors who referred to Shahid Sadoughi and Rahnemoon hospitals in Yazd from 2006 to 2016 and aged 1 to 18 years were evaluated. . The epidemiologic characteristics, survival, and the factors affecting the survival of brain and spinal cord tumors were investigated.
Results: The findings showed that between 30 studied patients, brain and spinal cord tumors were more common in males (19 males and 11 females). The average age of the patients was 8.60 ± 5.70 years. Fifteen (50%) patients survived. Seventeen (57%) patients were resident in Yazd province and 13 (43%) were from southern Iran. Twenty two patients (73.3%) had recurrence after recovery. The average of survival was 36 months, with an average of 27 months in females and 37 months in males. However, this difference was not significant. The most common tumor was gliomas. There was no significant relationship between the mean of survival with age, gender, geographical status, or type of treatment (P value> 0.05); however, there was a significant relationship between the year of tumor diagnosis and survival (P value=0.0134).
Conclusion: It seems that survival of the brain and spinal cord tumors in children and adolescence is a multifactor event and it is affected by various factors.
Dr Parisa Parsimehr, Dr Hayedeh Javadzadeh Shahshahani, Dr Fariba Binesh, Dr Mohammad Hossein Lookzadeh ,
Volume 10, Issue 2 (5-2020)
Abstract
Background: Blood transfusion is a relatively common practice in neonatal intensive care units (NICUs). Regarding that few studies have been conducted on infants in neonatal intensive care unit (NICU), this study was investigated the frequency of blood components usage for preterm infants in NICU.
Materials and Methods: This study was a cross-sectional descriptive-analytical study and was conducted on all neonates admitted to NICU of Shahid Sadoughi hospital. Information such as gestational age, sex, birth weight, and cause of hospitalization, number of injections, transfusion information, newborn status and delivery type were extracted from medical records. Chi-square test was used for the analysis of data. Statistically, P-value< 0.05 was assumed significant.
Results: In study, 44.6 % of patients were hospitalized due to prematurity and 19.5% due to respiratory distress syndrome. Among 816 NICU admissions, 370 (45.3%) received one or more blood components during their hospital stay, 61.6% received one, 26.2% two and 12% received three or four types of blood components. In total, 1719 blood components were requested in NICU. Of these, 21.5% were not used. The most frequent blood components used for neonates were fresh frozen plasma (FFP) (60%), leukoreduced red blood cells (RBCs) (26.5%) and platelet units (9.2%). Moreover, there was significant difference between the frequency using of blood components in terms of gestational age (p=0.001), birth weight (p=0.001), type of delivery (p=0.04), ABO blood group (p=0.001) and mortality (p=0.001).
Conclusion: The demand for blood components in NICU was high and one-fifth of requested blood was not used. Considering the high blood component usage, it is necessary to investigate the appropriateness of demands and transfusion of blood components in NICU. In addition, parameters including gestational age, birth weight and, type of delivery were related to the frequency of using blood components in NICU.
Dr Fariba Binesh, Dr Azam Sadat Hashemi , Dr Nazila Naghibzadeh, Mrs Fatemeh Pourhosseini , Dr Sara Mirhosseini ,
Volume 10, Issue 4 (10-2020)
Abstract
Background: Given that Hodgkin’s lymphoma (HL) accounts for 5%–6% of pediatric malignancies, we investigated the clinical characteristics and survival of pediatric patients with HL in our center.
Materials and methods: In this cross sectional and retrospective study, the medical charts of all patients under the age of 18 diagnosed with HL from 2006 to 2016 at Shahid Sadoughi Hospital Yazd, Iran, were retrieved. Data were analyzed by SPSS (version 18) using K square and T-Test. Survival was analyzed using Kaplan-Meier estimates, and multivariate analysis was performed using the Cox regression method.
Results: This study included 34 patients. In terms of gender, there were 20 boys and 14 girls in this study. The mean age of the patients was 10.42 years. The most common subtype of HL was mixed cellularity. Regarding disease stage, 55.9% of the patients were in stage I. All subtypes except for nodular sclerosis were more common in boys. The mean survival of patients in this study was 151.68 months. At the end of the study, there was just one death. The 5-year survival of patients was 100% and the 10-year survival was 94%. There was no significant relationship between survival and sex, histologic subtype, or the stage of the disease.
Conclusion: The results of the current study showed that majority of our patients had been diagnosed in a low stage and we achieved the best results for 5- and 10- year- overall survival through applied treatment.
Dr Farzad Ferdosian , Dr Fariba Binesh , Dr Marzie Vaghefi , Dr Ehsan Sanaei,
Volume 10, Issue 4 (10-2020)
Abstract
Kikuchi Fujimoto Disease (KFD), also known as necrotic histiocystic lymphadenitis, is a condition with unknown etiology. Probably, infectious, viral, and also autoimmune etiologies, especially lupus erythematosus, contribute to this disorder. The common signs are lymphadenopathy along with fever and leukopenia. Our case was a13-year-old boy with fever of unknown origin. He underwent ordinary fever of unknow origin (FUO) investigations and the only positive finding on his examination was lymphadenopathic fever of posterior cervical chain. The results of primary tests and also cultures of blood and urine samples did not have any specific contribution to diagnosis of infectious causes. Besides, bone marrow aspiration and biopsy led to the exclusion of chances of lymphoma or other malignancies. Finally, diagnosis of KFD was confirmed by the use of dissection of cervical lymph nodes and also via immunohistochemical tests and simultaneous positive antinuclear antibody (ANA). Hence, the patient was put on suitable medical treatment for lupus. Given the rare demonstrations of this case, i.e., the male sex and fever of unknown origin, and also the positive ANA despite clear clinical symptoms of lupus, this case was presented to provide both proper education and make a faster and more appropriate diagnosis.
Dr Ahmad Shirinzadeh, Dr Reza Ershadi, Dr Abdolhamid Amooee, Dr Jamal Jafari, Dr Hamidreza Soltani, Dr Shadi Kargar, Dr Fariba Binesh,
Volume 12, Issue 2 (4-2022)
Abstract
Pulmonary schwannoma is a rare neoplasm that arises from peripheral nerve sheath, Schwann cells, in the lungs and mostly remains asymptomatic for months. This report presents a seven-year-old female patient with an occasional cough and fever. She was hospitalized due to the lack of response to outpatient treatments, including antibiotics and antifebrile. A biopsy was taken from the mass by bronchoscopy, and the pathology report indicated the presence of a low-grade spindle cell, Verocay body, and Antoni B areas. Based on the pathologic findings, immunohistochemical (IHC) analysis was requested. The results indicated diffusely positive for S-100 protein, and accordingly, the diagnosis of schwannoma was confirmed. Thoracotomy and lobectomy were performed. Tracheobronchial schwannoma can be treated with surgical resection or bronchoscopy.
