Showing 9 results for Fallah
Md S Akhavan Karbasi , Md R Fallah , Md B Tirandazi , Md M Golestan ,
Volume 3, Issue 1 (3-2013)
Abstract
Abstract
Background
Febrile seizure (FS) is the most common childhood seizures which occur in 2-5% of children. Studies about association between iron deficiency and febrile seizure have shown contradictory results. The purpose of this study was to compare the iron status of children with first febrile seizure and healthy control group.
Materials and Methods
In an analytic case-control study , iron status of 6 to 60 months old admitted children with first FS to Shahid Sadoughi Hospital from December 2011 to August 2012 was evaluated and compared with healthy age and sex matched control children whom were referred for routine health care to primary health care center of Azadshar Yazd, Iran.
Results
Forty five (44%) girls and 55 boys with a mean age of 23.7 ± 14.3 months were evaluated. In children with FS , hemoglobin level (11.46 ± 1.18 g/dl vs. 11.9 ± 0.89 g/dl, p= 0.042) , serum iron levels (48.91 ± 22.96 μg/dl vs. 75.13 ± 35.57 μg/dl , p= 0.001) and serum ferritin level (38.52 ± 11.38 ng/ml vs. 54.32 ± 13.46 ng/ml, p= 0.001) were lower than in healthy children group .
Iron deficiency (48% vs. 28% , odds ratio 4.3, p=0.03) and iron deficiency anemia (22% vs. 10% , odds ratio = 3.16, p= 0.04) were more frequent in children with FS.
Conclusion
Based on the result of this study, iron deficiency could be an important risk factor for development of febrile convulsion. Evaluation of iron status is encouraged to be performed in children with febrile seizure.
Md L Borjianyazdi , Md M Froomandi, Md M Noori Shadkam , Md A Hashemi, Md R Fallah ,
Volume 3, Issue 2 (6-2013)
Abstract
Abstract
Background
This study was conducted to evaluate the clinical effect of Granulocyte Colony Stimulating Factor (GCSF) on prognosis of neonatal sepsis.
Materials and Methods
Present study is a double- blinded randomized clinical trial, conducted on 46 preterm infants with neutropenia (Absolute Neutrophil Count (ANC) ≤ 5000 / μL) and clinical sepsis. Infants were randomly allocated into two groups. In the first group (treatment group), infants were treated with GCSF for up to 5 consecutive days with 10 μg/ kg in addition to standard treatment protocols, and in other group, infants received normal saline as the placebo. Each infant was monitored for 14 days. Primary outcome was mortality during 14 days after entering the study, and secondary outcome was the incidence of positive blood culture, weight gain on the fourteenth day, the duration of hospitalization and medication side effects.
Results
In the treated group, only one death was observed (P-value=1.00). However, no positive results for cultures were reported.
Only one case in the treatment group and 3 patients in the control group showed feeding intolerance and needed respiratory support (P-value= 0.608). Length of hospitalization was 25 ± 6 days for the treatment group and 30 ± 7 days for the control group which was statistically significant (P-value=0.042).
Conclusion
The results of this study demonstrated that GCSF could reduce the hospital stay, but no significant effect was observed on mortality rate, respiratory or feeding status.
Msc L Fallahi , Md R Ghiliyan , Md A Hashemi, Md A Fatemi , Msc M Saeedi ,
Volume 3, Issue 3 (9-2013)
Abstract
Abstract
Background
Blood transfusion is associated with side effects caused by residual leukocytes in blood and blood components. Using leukodepleted blood components can decrease some of these adverse effects. Among the various methods to remove leukocytes in blood components, prestorage leukoreduction has been most efficient, but the evidence of clinical side effects awaits further studies. We evaluated changes of electrolytes in prestorage leukocyte-reduced red blood cells.
Materials and Methods
In this case-control study, one hundred twenty eight packed cells were studied: 64 unfiltered packed cells and 64 prestorage filtered packed cell. Two groups were matched as sex and age. Electrolytes such as Calcium, Sodium, and Potassium of two groups were measured, and compared during preparation.
Results
In this study, mean of Calcium in unfiltered and filtered group were 6.16±1.09 mg/dl and 5.57±2.21 mg/dl, respectively (P-value<0.055). Mean of Sodium in unfiltered group also was 155.91+/-9.51meq/l and in filtered group, 153.05+/-13.21meq/l (P-value<0.163), and mean of Potassium in unfiltered group was 5.01+/-1.72 meq/l and in filtered group, 7.42+/-2.45meq/l (P-value<0.001).
Conclusion
Releasing of Potassium during preparation of prestorage leukoreduction can cause increased Potassium level and hemoglobin concentration changes in prestorage filtered packed cell.
Dr R Fallah, Dr S Zare Bidoki, Dr M Ordooei,
Volume 6, Issue 1 (3-2016)
Abstract
Abstract
Background
Some researches have shown the association between iron deficiency and migraine headache in adults. The aim of present study was to evaluate efficacy of ferrous sulfate treatment on migraine headaches of 5-15 years old migraineur children with iron deficiency.
Materials and Methods
In a quasi- experimental study, monthly frequency, severity, duration and disability of headaches of 5-15 years old migraineur
children that prophylactic therapy was indicated in them and had iron deficiency who were referred to Pediatric eurology Clinic of Shahid Sadoughi University of Medical Sciences, Yazd, Iran between 2013 and 2015 and were treated with 2mg/kg/day topiramate plus 4mg/kg/day of ferrous sulfate for three consecutive months, were evaluated and headache characteristics before and after treatment were compared.
Results
In this study, 98 children with mean age of 9.72±3.19 were evaluated that 31children (31.6%) had iron deficiency. Monthly
frequency (22.89±7.18 vs.14.5±4.56, P= 0.02), severity score (8.12± 1.76 vs. 5.03±1.15, P= 0.02) and disability score of
headache (38.23±10.7vs. 30.12±7.46, P= 0.03) were more in children with iron deficiency. Iron therapy was effective in
decreasing of monthlyfrequency 22.89± 7.18 vs. 10.13±4.51, P = 0.001), severity score (8.12±1.76 vs. 5.11±1.62, P =0.001),
duration (2.14±1.23 vs.1.14±1.01, P= 0.001) and disability score of headache (38.23±10.7 vs. 22.87±8.65, P= 0.01).
Conclusion
In children, iron deficiency increased monthly frequency, severity and disability of migraine headache and ferrous sulfate
can be used as a safe and effective drug in migraine prophylaxis.
Dr Elnaz Sheikhpour , Mrs Zahra Sadri , Mrs Safiyehsadat Heydari , Mrs Fatemeh Ghanizadeh, Dr Hadi Zare-Zardini , Mr Aref Atefi, Dr Azam Hashemi , Mrs Tahereh Fallah , Mrs Esmat Ghiaspour ,
Volume 8, Issue 3 (5-2018)
Abstract
Vitamin D deficiency is known as the most common nutritional deficiency. It is created during infancy due to different factors, including decreased dietary intake, decreased dermal synthesis, malabsorption, enzyme-inducing medications, and exclusive breastfeeding. Vitamin D deficiency is associated with poor bone health such as rickets and osteomalacia in children. Despite vitamin D plays an important role in bone health, its role in pediatric cancer is not detected and remained unknown; therefore, the aim of this study was to evaluate the role of vitamin D deficiency and its relation with cancer in children. Vitamin D in cancer children has been considered as a contributory factor for skeletal pathologies. Children with cancer may be at increased risk of vitamin D deficiency due to side effects which are induced by the disease and multiple treatments, given that chemotherapy and clinical radiation play a main role in decreased bone mineral density. Therefore, possible role of vitamin D deficiency in cancer pathogenesis and progression is well defined. It seems that these patients should be taken sufficient amount of calcium and vitamin D during chemotherapy and afterward.
Dr Maryam Rassouli , Dr Naiire Salmani , Mrs Zahra Mandegari , Mrs Atena Dadgari , Mrs Bahare Fallah Tafti , Mrs Imane Bagheri ,
Volume 9, Issue 1 (1-2019)
Abstract
Pediatric palliative care is a holistic caring approach for children and families that begins with diagnosis of a life-threatening illness and continues until death; it aimed to relieve pain and other symptoms in physical, mental, social and spiritual aspects. In spite of available evidence concerning optimal outcomes of the provision of palliative care, establishment of a palliative care system for children has hardly been feasible so far due to a number of challenges. Therefore, this review study aimed at identifying the challenges of the provision of pediatric palliative care along with the relevant solutions. The identified challenges were classified into two categories including structure-based challenges (i.e. lack of a clear structure in the health system and classification of services, shortage of specialized staff, insufficient home care services, absence of health care tariffs along with insurance coverage of palliative care services) and process-based challenges (i.e. absence of guidelines, lack of educational programs for family, family attitudes and beliefs, communication barriers, and lack of access to opioids). Thereafter, the solutions for each challenge are provided in accordance with the available literature separately. Given the significance of palliative care for children with cancer and in order to improve the quality of life of the children and the families, it appears necessary that policymakers and managers take account of the challenges as well as the feasibility and the implementation of provided solutions.
Dr Azam Hashemi, Dr Maliheh Kokab, Dr Masoud Kamalian, Dr Mohammad Zarezadeh, Dr Elnaz Sheikhpour, Ms Leila Azod, Ms Tahereh Fallah,
Volume 10, Issue 3 (7-2020)
Abstract
Background: Given that few studies regarding the effect of Aloe vera (A. vera) on prevention of fever and neutropenia on acute lymphoid leukemia (ALL) disease, the aim was to evaluate the effect of A.vera on prevention of fever and neutropenia in children with ALL.
Materials and Methods: This randomized clinical trial study was conducted on 60 children with mean age 5.6± 2.9 years in Oncology department of Shahid Sadoughi hospital during 2018-2019. All these children were underwent chemotherapy. Then, the patients were randomly classified into two groups. The first group received 10 ml A. vera syrup (0.5 mg/ml) for 30 days (case group) and the second group did not receive A. vera syrup (control group). Complete blood count (CBC) tests and frequency of fever, infection, neutropenia, and hospitalization were evaluated in case and control groups before and after intervention. Wilcoxon, T test, and Chi Square test were used for data analysis.
Results: Significant reduction was observed in case group in comparison with control group regarding the frequency of fever (0.19 ±0.107 vs 1.07±0.206), infection (0.81 ±0.2 vs 1.87± 0.236), hospitalization (0.37±0.178 vs 1.33 ±0.187), and neutropenia (0.11± 0.062 vs 0.80 ± 0.2) (p<0.01). Moreover, significant increase was observed in case group in comparison with control group considering neutrophil count (2597.5±243.1 vs 1106.53±161.6) and white blood cell (WBC) (4062.96 ± 276.6 vs 2566.67 ±175.5) (p<0.01). In addition, recovery of appetite was significantly greater in case group than control group (p=0.023). Furthermore, significant difference was observed in case group before and after intervention regarding these parameters (p<0.05).
Conclusion: According to findings, A. vera consumption decreased frequency of infection, neutropenia, fever, and hospitalization and increased WBC and neutrophil count. Moreover, appetite was improved in these patients. Therefore, it seems that A.vera can be used for improving quality of life in children with ALL
Dr Farzad Ferdosian, Dr Razieh Fallah, Dr Zeynab Dehghani,
Volume 10, Issue 3 (7-2020)
Abstract
Background: Lumbar puncture (LP) is a worth procedure in diagnosis of oncological diseases and intrathecal administration of antineoplastic drugs. The effort should be to minimize pain of LP in children with cancers. This clinical trial was done to compare success rates in performing LP and reducing anxiety and pain of LP in sitting and lateral decubitus positions in 1 to 5-year-old children.
Materilas and Methods: In a not-blinded clinical trial, 80 children aged 1-5 years, undergoing LP in Pediatric Ward of Shahid Sadoughi Hospital, Yazd, Iran, from May to September 2019, were randomly allocated to two groups. Intravenous 0.5mg/kg midazolam was injected in all patients five minutes before LP, and LP was performed in sitting position in group I and in lateral decubitus position in group II. Primary outcomes included rate of successful LP, anxiety and pain scores before LP and during needle insertion to skin for LP, and secondary outcomes comprised of success rates in decrease of anxiety (anxiety score of four and more) and pain (pain score of less than three) when the needle was inserted to skin for LP.
Results: Thirty-eight girls and 42 boys with the mean age of 2.51 ± 0.32 years were evaluated. Success rates in performing LP (70 % in sitting vs. 65% in decubitus position, P=0.5), decrease of LP anxiety (77 % in sitting vs. 75% in decubitus groups, P=0.8) and reduction of pain during skin needle insertion for LP (72 % in sitting vs. 67% in decubitus position, P=0.7) were not significantly different between the two positions.
Conclusion: Rates of success in performing LP and reduction of its pain and anxiety in children were equal in lateral decubitus and sitting posi¬tions and, in 1 to 5-year-old sick children with or without cardiorespiratory difficulties, LP can be done in lateral decubitus or sitting position.
Dr Azam Hashemi, Dr Morteza Zangeneh Soroush, Dr Elnaz Sheikhpour, Ms Fatemeh Ghanizadeh, Dr Farimah Shamsi, Dr Bahareh Fallah, Dr Leila Kazemy,
Volume 12, Issue 4 (10-2022)
Abstract
Background: β-thalassemia is the most common hereditary disease in Iran, and more than 2 million carriers of β-thalassemia live in Iran. On the other hand, our country is located in the thalassemia belt, and no comprehensive study has been conducted regarding the effect of erythropoietin on blood parameters in thalassemia intermedia patients in our region. Therefore this study aimed to investigate the effect of erythropoietin on blood parameters of thalassemia intermedia patients.
Materials and Methods: This prospective cross-sectional study was conducted on all patients suspected of thalassemia intermedia in Shahid Sadoughi hospital from March 2021 to M 2022. In the case of diagnosis of microcytic anemia, an electrophoresis test was performed, and people diagnosed with thalassemia intermedia entered the study. Then patients were divided into two groups (the intervention and control groups). The erythropoietin dose was 50-100 units/ kilogram (body weight) three times a week for six months. The measurement of hematocrit and hemoglobin were done using CBC cell counter (Sysmex KX21). Other data were extracted from medical records.
ResultL: In the current study, the mean age of patients in the intervention and control groups was 9.15±1.53 and 8.35± 6.90 years old, respectively (p=0.9). The mean hematocrit level in the intervention and control groups was 28.05± 4.06 and 23.45± 3.22 %, respectively (P<0.001). The mean hemoglobin level in the two groups was 9.15± 1.53 and 7.65± 1.23 g/dL respectively (p=0.002). The mean hematocrit level before and after the intervention was 25±3.71 and 28.05±4.06 %, respectively. The mean hemoglobin levels before and after therapy were 7.9±1.52 and 9.15±1.53 g/dL, respectively.
Conclusion: According to the findings, hemoglobin and hematocrit increased in thalassemia intermedia patients taking erythropoietin. Therefore it seems that recombinant erythropoietin can be helpful in these patients.
