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Abstract Background Limb gangrene in neonates is an extremely rare clinical problem and very few cases have been recorded up to now. The clinical findings were mild involvement of skin to full necrosis and gangrene of the involved regions. Unfortunately, in most cases the etiology cannot be established. However, a variety of etiological causes may account for this condition. Case Presentation We present a newborn baby with symmetrical peripheral gangrene of the limbs, both flanks, chin, and scrotum due to leukocytoclastic vasculitis with unknown cause. He was treated by parenteral glucocorticoid, broad-spectrum antibiotics, heparin, hydralazine and fresh frozen plasma (FFP). He died after 2 weeks of intensive treatment. There is history of the same disease in two infants of his paternal aunt, both of them were dead soon after birth. Conclusion Peripheral gangrene with symmetrical involvements, due to vasculitis, is a very unique disorder in newborn infant, which no case was reported up to now.

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Abstract Background Infantile Fibrosarcoma is a rare soft tissue tumor in infants and children mostly located in extremities. An infantile and adult form has similar histopathological patterns but survival prognosis is much better in infantile form. Recurrence of infantile fibrosarcoma is common but the rates of metastasis are less than 10 percent in children younger than five Years and 50 percent in children more than 10 years old. Case presentation In this case report, we presented a nine years girl with a relapsing mass in her left hand. The pathologic findings showed sheets of spindle-shaped cells with suggested diagnose of infantile fibrosarcoma. She was successfully treated with combination of surgery and chemotherapy with a good outcome. Conclusion Infantile fibrosarcoma is a differential diagnose of soft tissue mass in infants and children. It has a good prognosis and distant metastasis is uncommon. Choice of treatment is surgery but chemotherapy and radiotherapy were useful in decrease metastasis.

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by increasing number of vessels. Salivary gland tumors are uncommon and their overall incidence is about 3 per 100000 per year. Salivary gland hemangioma makes up 1 % of all salivary gland tumors. Trismus resulting from parotid hemangioma is so rare. The patient was a 6-month-old boy with a huge lesion in his right parotid who referred to Shahid sadoughi hospital of Yazd, Iran. The lesion appeared at 4 months of age and had rapid growth and was suspected as hemangioma after clinical examination and patient had trismus. The lesion was excised without

any complications. Five months after surgery, area of the lesion appeared normal. Parotid hemangioma has low potential to turn into malignant form but early detection and biopsy are necessary for decreasing complications. Removal of the mass was the best treatment for the patients with large or complicated hemangioma however, it should be performed with caution because the tissues may bleed profusely. Patients may have long term survival after surgery.

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Fibroadenoma is the most common benign mass of breast in females 20-50 years of age. Juvenile fibroadenoma accounts for only 4% of total fibroadenomas. Moreover, the incidence of giant juvenile fibroadenoma is found to be only 0.5% of all fibroadenomas. A 15-year-old woman at the 12th week of gestation was referred to the Shahid Sadoughi Hospital, Yazd, Iran because of a mass in the right breast from one year ago. On Physical examination and imaging, a large mass was found in her right breast. Fine needle aspiration biopsy reported fibroadenoma. Mass enucleation and breast reconstruction were performed. Pathologic examination confirmed a giant fibroadenoma. No serious complications were reported during one-month follow up. The most highlighted point of this presentation was giant size of juvenile fibroadenoma in a pregnant woman. This case report shows that large breast tumors in the adolescent age group can be benign and breast-conserving surgery should be considered in such cases.