Showing 9 results for Rezaei
Shokoh Taghipour Zahir, Mohammad Rezaei Sadrabadi , F Dehghani,
Volume 1, Issue 4 (12-2011)
Abstract
Abstract
Background
Cerebral neoplasm arises from brain, spinal cord and meningeal cells. Not only malignant cerebral neoplasm also benign tumor could lead to death due to mass effect on vital structures. Access to these tumors is difficult, and MRI and CT scan could be helpful in determining anatomical location of tumors and distinction of malignant from benign.
Objective
For better and earlier diagnosis and treatment, present study determined the accuracy of MRI and CT scan in compare with pathological findings.
Materials and Methods
This experimental case-series study compare the results of tumor imaging (MRI and CT scan) with biopsy in patients who came with brain mass between April 2004 and April 2010. Demographic characteristic and medical history were recorded. The results of CT scan, MRI and biopsy reports were recorded for patients, and all data compared and analyzed by SPSS software version 15.
Results
Results of 218 patients were analyzed. 189 patients had definite diagnosis using CT scan, which 13 (7.2%) were diagnosed benign and 159 (92.4%) malignant. Sensitivity, specificity, positive predictive value and negative predictive value of CT scan in comparison with biopsy were 83%, 10%, 93% and 3% respectively. The accuracy of this method was 78%. Fifty four patients (24.4%) were evaluated by MRI. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of MRI were 92%, 25%, 93%, 2% and 87% respectively.
Conclusion
According to the results, positive results by MRI and CT scan are valuable and have diagnostic value, but negative reports need more evaluation and no roll out malignant tumor. So remarkable specificity, but low sensitivity were achieved for CT scan and MRI. They accepted as easier and more accessible methods to approach brain tumors.
Md A Ghadiri Anari , Md R Ghiliyan R , Md G Rezaeian ,
Volume 2, Issue 2 (6-2012)
Abstract
Abstract
Background
Prolonged P-wave duration and P-wave dispersion indicate interatrial conduction disturbance and early predict arrhythmia especially atrial fibrillation. Iron deposition in the atrial tissue might prolonged the atrial conduction time, and this study evaluated the P-wave prolongation and increased P-Wave dispersion in these patients.
Materials and Methods
Fifty patients with major thalassemia and fifty healthy controls were studied, which age and sex matched between cases and controls. All patients and the controls were examined and had an ECG. The P-wave dispersion defined as the difference between the maximum and minimum P-wave duration. P-wave dispersion was compared between two groups. student^,s T-test and pearson^,s correlation were used as needed.
Results
There was a significant difference between the P-wave dispersion of the 2 groups (P=0.019). Maximum P-wave duration and P-wave dispersion in patients had strong correlation with age (disease duration). P-wave duration and P-wave dispersion had no correlation with regularity or irregularity of desferal use.
Conclusion
Maximum P-wave duration and P-wave dispersion were seen in older cases, which significantly get prolonged. This could show that the myocardial involvement and dysfunction was probably more in the older patients.
Bsc M Mehrabi, Phd A Javid, Md A Hashemi, Phd S Rezaei-Zarchi,
Volume 3, Issue 2 (6-2013)
Abstract
Abstract
Background
Nanoparticulate drug delivery systems have attracted significant attention in the field of cancer nanotechnology. This study determines the effect of folate-based Fe2O3 nanoparticles. This study aimed to decorate nanoparticles with folate (FA), a molecular ligand for ‘active’ targeting of cancerous cells and the application of modified-nanoparticles in cancer treatment.
Materials and Methods
The nanoparticles were prepared by a solvent evaporation and emulsification cross-linking method and anticancer activity of agent was evaluated on CCRF CEM cells, derived from human blood cancer samples.
Results
The physicochemical properties of the nanoparticles were characterized by various techniques, and uniform nanoparticles with an average particle size of 110±15 nm were obtained. Cytotoxicity tests showed that the SPIO-FA had higher cell toxicity, and confocal microscopy analysis confirmed excellent cellular uptake efficiency.
Conclusion
These results indicate that FA based SPIO-NPs have potential uses as anticancer drug carriers and also have an enhanced anticancer effect.
Mr J Manoochehri , Dr R Masoumi Dehshiri , Dr H Faraji , Mr S Mohammadi , Mr H Dastsooz , Mr T Moradi , Mr E Rezaei , Mr Kh Sadeghi , Dr M Fardaei ,
Volume 4, Issue 1 (3-2014)
Abstract
Background
Wilson disease (WD) is a rare autosomal recessive disorder, which leads to copper metabolism, due to mutations in ATP7B gene. The gene responsible for WD consists of 21 exons that span a genomic region of about 80 kb and encodes a copper transporting P-type ATPase (ATP7B), a protein consisting of 1465 amino acids. Identifying mutation in ATP7B gene is important to find carrier individuals for proper counseling. A novel mutation in exon 8 of ATP7B gene, c.2335T>G (p.Trp779Gly), with severe neuropsychiatric condition in the South of Iran, was recently identified.
The aim of this study was to screen 120 individuals from a large family using a simple amplification refractory mutation system PCR (ARMS-PCR) for carrier screening in the South of Iran.
Materials and Methods
120 individuals from family relatives of an index case in the Nasr Abad, south of Iran, were studied for screening of the c.2335T>G mutation. One patient with homozygous mutation and one homozygous normal individual were used as controls in this experiment.
Results
Altogether, 16 out of 120 (13.3%) individuals within this region had heterozygous mutation. One individual with homozygote mutation was also identified.
Conclusion
Identification of carriers in families with affected individuals is of great importance for counseling before marriage. The results of this study can be used for further counseling programs in this population.
Dr Leila Tahmasebi, Dr Sezaneh Haghpanah , Dr Narges Rezaei , Dr Mehran Karimi ,
Volume 6, Issue 4 (11-2016)
Abstract
Abstract
Background:
Hereditary red cell enzyme disorders are a group of Non-immune/Spherocytic Hemolytic Anemia, although these disorders are rare and they have not public health problems, the detection of these defects could help to physician in treatment and differential diagnosis. This study evaluated 5 enzymopathies in patients with Hereditary Non –immune/Spherocytic Hemolytic Anemia (HNSHA) during one year.
Materials and Methods:
This cross-sectional study, evaluated 5 erythrocyte enzymes in 22 patients (mean age of 10 ± 9.3) with Hereditary Non-immune/ Spherocytic Hemolytic Anemia in Southern Iran from Jan 2014- Feb 2015. Evaluated erythrocyte enzymes consisted of pyruvate kinase (PK), G6PD, Catalase, Glutathion Proxidase( GP) and Glutathion Reductase( GR), all of these enzymes checked by quantitative assay except G6PD that evaluated by qualitative activity assay. The clinical and para clinical data were gathered from patient’s documents. Results: Results showed that 2 patients were PK deficient (9.1 %), 4 patients were G6PD deficient (18.2%), 1patient was GP deficient (4.5%), 1 patient was Catalase deficient (4.5%) and there is no patient with GR deficiency.
Conclusion:
This study showed that enzymopathies should be into consideration in patients with non-immune hemolytic anemia, if other common causes of hemolysis such as hemoglobinopathies and membranopathies have been excluded.
Dr Vahid Baghdadi, Dr Fatemeh Yari, Dr Negar Rezaei, Dr Mohammad Hessam Rafiee,
Volume 9, Issue 2 (3-2019)
Abstract
Background: Storage of platelet concentrates (PCs) at room temperature (20-24°C) limits its storage time to 5 days due to the destructive effects of platelet storage lesion (PSL) and bacterial contamination. Although prolonged storage of platelets (PLTs) at 4°C reduces the likelihood of bacterial contamination and PSL levels, it is accompanied by an increase in the clearance rate and changes in the surface markers of PLTs. The goal of this study was to evaluate the effects of sodium octanoate (SO) as a stabilizer on PLTs during storage at 4°C.
Materials and Methods: In this experimental study, PCs were divided into three portions and stored for 5 days at 3 different conditions, including 20-24°C, 4°C temperature, and 4°C in presence of SO. PLTs enumeration was performed using an automated hematology analyzer. To measure the metabolic activity and survival rate of PLTs, the water-soluble tetrazolium salt (WST-1) assay was performed. The activity of lactate dehydrogenase enzyme (LDH) was measured by a biochemical analyzer. Additionally, the levels of PLT glycoprotein Ibα (GPIbα) and CD62P (P-selectin) were measured on PLTs by flow cytometry technique.
Results: PLTs count was higher in SO-treated (4°C) PLTs than two other studied samples. Additionally, the viability was higher in the SO-treated PLTs than that in other groups. LDH amount was lower in the SO-treated PLTs than that in other groups (P>0.05). GPIbα expression was significantly higher in SO-treated PLTs than that other groups (P<0.05). On the other hand, the expression of CD62P was lower at 4°C in PLTs in the presence of SO (P>0.05).
Conclusions: SO could modulate the effects of cold temperatures on PLTs. Furthermore, we found that the survival of platelets was better maintained in the presence of SO at 4°C.
Mrs Tahereh Dargahi, Dr. Fatemeh Yari, Dr. Negar Rezaei,
Volume 9, Issue 4 (10-2019)
Abstract
Background: The origin and function of human leukocyte antigen (HLA) class I molecules on platelets are still highly arguable. Given the differences in the results of the previous studies in this regard, the lack of research in recent years, and the clinical importance of HLA class I molecules, the absorption capacity of platelets for soluble HLA class I molecules was studied in this investigation.
Materials and Methods: In this experimental study, HLA-A2 antigen was purified from a B cell precursor leukemia cell line (Nalm-6) by cell membrane protein solubilization and usage of HLA-A2 affinity column. Platelet concentrates (PCs) were received from Tehran Blood Transfusion Center. Eighteen bags of HLA-A2-negative PCs were prepared randomly and treated with various concentrations of the purified HLA antigen (100, 500, and 1000 ng/ml) for 48 to 72 hours. Subsequently, the HLA-A2 levels were evaluated on platelets by flow cytometery technique. Data were evaluated using repeated measure ANOVA.P-values less than 0.05 were considered significant.
Results: The results of this study showed that the purified protein was an HLA molecule (HLA-A2). After the treatment of platelets and HLA molecules, platelets inability was shown for the attracting of HLA molecules. This finding was true in both media of RPMI and plasma. The differences between the case (HLA-treated platelets) and control (untreated platelets) were not significant (p-values> 0.05).
Conclusion: Platelets were unable to significantly adsorb exogenous HLA antigens from their environment. Further studies are needed to unravel the nature and origin of HLA molecules on platelets.
Dr Hamid Farhangi, Dr Ali Ghasemi, Mrs Mojgan Bahari, Mrs Zohreh Alirezaei, Mrs Akram Rabbani Javadi, Dr Zahra Badiee, Dr Fatemeh Nanvabashi,
Volume 12, Issue 1 (1-2022)
Abstract
Background: Nausea and vomiting are among the most important side-effects associated with chemotherapy in children with cancer, affecting the quality of their lives. Clinical guidelines for selecting antiemetics are effective in reducing acute chemotherapy-induced nausea and vomiting (CINV).
Materials and Methods: The present quasi-experimental study compared the effectiveness of the Pediatric Oncology Group of Ontario (POGO) CINV guideline with that of conventional arbitrary therapies for CINV in 82 children aged 6 months to 16 years old. Out of 177 cycles of chemotherapy, in 101 cycles patients were treated according to POGO-CINV Guideline; in the other 76 cycles, patients were treated with arbitrary types and doses of antiemetics. Then, vomiting in the first 24 hours after chemotherapy in both groups was measured and compared.
Results: In this study, 82 patients hospitalized in the Hematology Department of Dr. Sheikh Children’s Hospital were enrolled, of whom 48 patients (58.7%) were boys and 34 (41.3%) were girls. The mean age of patients was 6.24±4.47 years (6 months to 16 years). The results of the current study showed that using a protocol for the prevention of vomiting based on the patient’s age and the type of chemotherapy is superior to conventional management of CINV. Findings showed that the frequency of nausea and vomiting in the protocol group was significantly reduced in comparison with the control group (p˂0.005). Moreover, a reduction in the frequency of nausea and vomiting was quite significant in the sub-categories of the protocol group who had received high-risk or moderate-risk emetogenic drugs (p˂0.005).
Conclusion: The results of the current study showed that using the POGO guideline, which takes into account the patient’s age and the type of chemotherapy, is more effective than arbitrary management of CINV, particularly in children.
Dr Ehsan Rezaeinezhad, Dr Morteza Zangeneh Soroush, Dr Fatemeh Poorhosseini, Dr Azam Hashemi,
Volume 14, Issue 4 (10-2024)
Abstract
Background: Vitamin D deficiency is prevalent among patients with sickle cell disease, regardless of their age or the season. Since there has been no extensive research on the impact of vitamin D on pain in sickle cell disease, this study aimed to evaluate how vitamin D supplementation influences pain management in these patients.
Materials and Methods: This retrospective study was conducted on children (12.3±4.45 years old) with definitive diagnosis of sickle cell. The study was done in the Department of Oncology of Shahid Sadoughi Hospital, Yazd, Iran, over the years 2019-2021. Thirty patients (14 boys and 16 girls) with vitamin D insufficiency and deficiency entered the study and 50000 IU vitamin D was given weekly for 16 weeks. The measurement of vitamin 25(OH) D3 before and after intervention was done by ELISA method (Monobind kit, USA). Pain intensity assessment was also done. Other relevant data were extracted from the patients’ medical records.
Results: In this study, amomg 30 patients, 46.6% of them had vitamin D deficiency. A significant reduction in pain intensity was observed in patients following the intervention (p<0.05).
Conclusion: Based on the findings of this study, vitamin D was effective in reducing pain intensity in these patients. Therefore, vitamin D can be used in the pain management of these patients.
