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Abstract Background Cerebral neoplasm arises from brain, spinal cord and meningeal cells. Not only malignant cerebral neoplasm also benign tumor could lead to death due to mass effect on vital structures. Access to these tumors is difficult, and MRI and CT scan could be helpful in determining anatomical location of tumors and distinction of malignant from benign. Objective For better and earlier diagnosis and treatment, present study determined the accuracy of MRI and CT scan in compare with pathological findings. Materials and Methods This experimental case-series study compare the results of tumor imaging (MRI and CT scan) with biopsy in patients who came with brain mass between April 2004 and April 2010. Demographic characteristic and medical history were recorded. The results of CT scan, MRI and biopsy reports were recorded for patients, and all data compared and analyzed by SPSS software version 15. Results Results of 218 patients were analyzed. 189 patients had definite diagnosis using CT scan, which 13 (7.2%) were diagnosed benign and 159 (92.4%) malignant. Sensitivity, specificity, positive predictive value and negative predictive value of CT scan in comparison with biopsy were 83%, 10%, 93% and 3% respectively. The accuracy of this method was 78%. Fifty four patients (24.4%) were evaluated by MRI. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of MRI were 92%, 25%, 93%, 2% and 87% respectively. Conclusion According to the results, positive results by MRI and CT scan are valuable and have diagnostic value, but negative reports need more evaluation and no roll out malignant tumor. So remarkable specificity, but low sensitivity were achieved for CT scan and MRI. They accepted as easier and more accessible methods to approach brain tumors.

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Abstract Background Involvement of lacrimal apparatus by Non Hodgkin lymphoma as a first manifestation is extremely rare and only three cases have been reported in children. The purpose of this report is to determine the clinical characteristic of patient with primary involvement of lacrimal apparatus with lymphoma. Case presentation A 7-year-old girl with history of tearing, gradually progressive periorbital redness and painless swelling over right lacrimal apparatus for almost 40 days was referred for treatment in our clinic. Orbital computed tomography revealed lacrimal apparatus mass. Histopathological examination demonstrated B cell type NHL. Following three cycles of cyclophosphamide, doxorubicin hydrochloride, vincristine and prednisone (CHOP regimen) and radiotherapy, the patient was discharged with good condition. Conclusion Although, the primary lacrimal apparatus lymphoma is extremely rare in children but malignant lymphoma should be taken under consideration in acute dacriocystitis.

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Abstract Background Breast carcinoma is uncommon in women under 25 and very rare in less than 20 years old. Only few cases of infiltrating breast carcinoma have been reported and among them there was no report of medullary subtype. The purpose of this report is to determine clinical, histopathological and sonographic findings of large mass in breast of young female patient that diagnosed as medullary carcinoma. Case presentation A 17 year-old female with large mass in her right breast was referred to our clinic. In clinical examination the mass had a fleshy to firm consistency and the borders were not infiltrative. Ultrasonography findings were highly suggested for fibroadenoma. Histopathological examination demonstrated infiltrating breast carcinoma with medullary feature. Conclusion Although breast carcinoma is very rare in patients under twenty years old, in this age group a differential diagnosis with fibroadenoma should be considered.

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Abstract Background In Acute Myeloid Leukemia (AML), malignant clones of immature myeloid cells (primarily blasts) proliferate, replace bone marrow, circulate in blood and invade other tissues. The unique presentation of unilateral ptosis and unilateral eyelid swelling in AML has been reported during the present study. Case Report A 7-year-old girl was encountered with progressively increasing unilateral right eyelid swelling and ipsilateral ptosis. There was no systemic manifestation of leukemia. Computed tomographic image reported right orbit anteromedial mass. A high total leucocytic count in cell blood count with low platelet, the bone marrow aspirate and biopsy showing leukemic blast cells confirmed the diagnosis of AML. After diagnosis, an orbital MRI was done, which revealed a mass lesion antromedial of right orbit related to soft-tissue tumor. The patient was treated by chemotherapeutic drugs associated with intravenous steroids. Conclusion Unilateral ptosis and eyelid swelling is an initial manifestation of AML that has not been reported previously. A peripheral blood smear with bone marrow aspirate and biopsy helps in the early detection of AML. We should consider AML in any orbital mass with unknown origin.

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Abstract Background Follicular lymphoma (FL) is the second most common adnexal lymphoma of the eye that almost all of them are reported in elderly patients. Primary FL of the eye has been reported in only two children. Pediatric FL appears to be biologically distinct from typical adult FL. In cases without other organ involvement excision alone with close monitoring is a treatment of choiceand the prognosis is excellent. Case presentation A 12 year -old male with a nodular lesion involving the inner can thus of the right eye was admitted to ophthalmology clinic. The lesion was painless and the nodule size gradually increased over a period of 6 months.Excisional biopsy demonstrated follicular lymphoma composed of neoplastic lymphoid cells which arranged in follicular pattern without germinal centers. Neoplastic cells were positive for Bcl2 and CD20. Conclusion Although follicular lymphoma of the conjunctiva is rare in childhood but it could be considered as one of the differential diagnosis in this age group.