Showing 3 results for verma
M.d R Gupta, Md S Verma , Md M Bhargava , Md Sk Mittal,
Volume 3, Issue 1 (3-2013)
Abstract
Abstract
Background
Delta beta (δβ) thalassemia is an unusual variant of thalassemia with elevated level of fetal hemoglobin (HbF). Homozygous patients of this disorder, unlike β-thalassemia, show mild anemia. Only few cases of δβ-thalassemia have been reported from India in the available indexed English literature.
Case presentation
A four-year old male child was evaluated for recent-onset jaundice. Hematological investigations showed mild anemia with microcytic hypochromic red cells. A comprehensive analysis of hemoglobin by high-performance liquid chromatography (HPLC) showed complete absence of HbA and HbA2 with HbF constituting 100% of the hemoglobin. Hemoglobin analysis of both parents showed elevated level of HbF with normal HbA2. A final diagnosis of δβ-thalassemia in the child with both parents being carriers was rendered.
Conclusion
Delta beta-thalassemia is an uncommon cause of markedly elevated fetal hemoglobin beyond fetal period. Clinical and haematological parameters should be evaluated to render an accurate diagnosis.
Dr. Henu Kumar Verma, Dr. Yashwant Kumar Ratre, Dr Bhaskar Lvks, Dr Tarun Sahu, Dr Devendra Purushottam Lingojwar,
Volume 12, Issue 4 (10-2022)
Abstract
Background: Sickle cell anemia (SCA) is an inherited monogenic disorder. The clinical symptoms of SCA are protean, including vaso-occlusion, hemolysis, early stroke, leg ulcers, multi-organ failure, and increased risk of premature death. Hematopoietic stem cell transplantation is the only treatment identified to reduce SCA-related organ damage. Unfortunately, graft rejection is a significant impediment to these strategies.
Materials and Methods: The current standard of treatment for the past two decades is limited to myeloablative-matched sibling donors, which is likely to be only for minor patients and is feasible for non-malignant giant disease. Cumulative studies showed that HSCT increases overall survival and quality of life in patients with SCA.
Results: Hematopoietic stem cell transplantation (HSCT) is significantly associated with a higher risk of graft versus host disease and moderate mortality risk. New strategy lacking standard donors includes cord blood, matched unrelated donors/ Haploidentical donors.
Conclusion: This review summarized evidence from HSCT clinical trials from different transplantation methods, specific HSCT and HSCT-related health problems that need to be addressed in medical contexts with patients and family members, and other areas that enhance the quality of life in SCA.
Dr Ruchee Khanna, Dr Anjali Chaurasia, Dr Seemitr Verma, Dr Vinay Khanna,
Volume 15, Issue 2 (3-2025)
Abstract
Acute lymphoblastic leukemia (ALL) accompanying with hypereosinophilia is an extremely rare blood cancer, with an incidence rate of less than 1%. In most cases, patients with ALL and hypereosinophilia rarely show blasts in the peripheral blood, which can potentially lead to misdiagnosis. This study presents a case of an 18-year-old male who was initially diagnosed with Idiopathic Hypereosinophilic Syndrome (IHES) and later found to have B-cell ALL with hypereosinophilia. The patient presented with complaints of excessive weight gain, easy fatiguability, stretch marks on the skin, and mild limb pain. Initial blood examinations revealed leucocytosis with eosinophilia and atypical cells. Bone marrow examination and flow cytometry confirmed the diagnosis of B-cell ALL with eosinophilia. For adolescents and young adults with hypereosinophilia, a comprehensive clinical assessment should be conducted. This includes a complete blood count with differential analysis, peripheral blood smear examination, as well as bone marrow aspiration and biopsy. Flow cytometry and cytogenetic studies of the bone marrow are crucial to confirm ALL diagnosis and to identify any associated genetic abnormalities. The most frequently observed genetic abnormality in patients with ALL and hypereosinophilia is the translocation t (5; 14) (q31; q32), which results in the overproduction of interleukin (IL)-3, IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF). This case underscores the importance of maintaining a high level of clinical suspicion and performing a thorough evaluation when managing adolescents and young adults presenting with atypical manifestations of ALL.
