Showing 4 results for Glucose
Ha Izadpanahi, Fateme Yari, Mr Khorramizadeh, M Maghsudlu,
Volume 1, Issue 3 (9-2011)
Abstract
Abstract
Objective
Removing plasma from the platelet concentrate (PC) medium could be an effective way to increase the safety of this product. The goal of this study was to compare PC stored in plasma or in an additive solution (Composol) with in vitro testing.
Materials and Methods
Fifty-four single donor PCs were prepared from Iranian Blood Transfusion Organization (IBTO). Each PC unit was divided into two portions. Then in one of the portions, plasma was replaced with Composol. Sampling was carried out at the days 2, 4 and 7 from the preparation time. The levels of pH, glucose, lactate and lactate dehydrogenase (LDH) were analyzed by colorimetric methods.
Results
The levels of pH and glucose were decreased during storage whereas the levels of LDH and Lactate were increased with time over. At the day 7 of storage, the mean values for glucose were 404.44 and 25.19 mg/dl in plasma and Composol, respectively. These values were 3306.1 and 683.33 U/L for LDH and 142.07 and 90.90 mg/dl for lactate. The differences between LDH, lactate, and glucose levels were significant between the two storage media of plasma and Composol (P-value<0.001).
Conclusion
This study could imply the potential capacity of an additive solution as a candidate for plasma replacement in PC in vitro.
Dls M Pahlavanzadeh , Md S Hekmatimoghaddam , Msc M Teremahi Ardestani , Msc M Ghafoorzadeh , Bsc Mm Aminorraaya ,
Volume 3, Issue 2 (6-2013)
Abstract
Abstract
Background
About 7.5% of the world population carries one or two deficient copy of glucose-6-phosphate dehydrogenase (G6PD) genes. According to WHO, its prevalence in Iran is 10 to 14.9%. This study aimed on determination of frequency of G6PD deficiency in neonates with jaundice who were hospitalized during 6 months (September 2008 to February 2009) in the city of Yazd, Iran.
Materials and Methods
In this study, 105 icteric neonates in the hospitals of Yazd were evaluated. Data was collected from hospital records, and the G6PD activity was measured by photometric biochemical assay. Statistical analysis of data was performed by the SPSS-16 software, using Student's t-test and Pearson's chi-squared test.
Results
Between all of studied neonates, 19 (18.1%) had G6PD deficiency, and consisted of 15 boys (29.4% of boys)
and 4 girls (7.4% of girls). In 100% of cases, the jaundice began in the first week after birth. The average total serum bilirubin at hospitalization was 17.22 mg/dL. In 31.5% of the G6PD-defficient neonates, exchange transfusion became necessary, which is significantly more than the rate in G6PD-sufficient (4.6%) neonates (P-value<0.05).
Conclusion
In general, the frequency of G6PD deficiency in this study seems quite high. Regarding its severity and frequent need for exchange transfusion, we recommend that all of the icteric neonates should be evaluated for G6PD activity. Also, it is better to test for G6PD deficiency in all of the neonates, to detect its presence and to prevent its complications such as favism and oxidant drug-induced hemolysis, since the test has a low cost.
Dr Bahram Darbandi , Dr Sharareh Zarezadeh , Dr Zahra N Atrkar Rosha, Mrs Afagh Hassanzadeh Rad , Dr Adel Baghersalimi ,
Volume 7, Issue 4 (9-2017)
Abstract
Background: Glucose-6 phosphate dehydrogenase (G6PD) deficiency is the most common inherited enzyme deficiency of red blood cells involving the enzyme pathway of hexose monophosphate. This study was conducted to examine the effect of vitamin E and folic acid on the improvement of acute hemolysis caused by the G6PD deficiency in patients referred to 17 Shahrivar Hospital, Rasht.
Materials and Methods: This was a randomized clinical trial conducted on 120 patients with G6PD deficiency. The patients were divided in 4 groups, including vitamin E, folic acid, a combination of both supplements, and control groups. The hemoglobin level and the reticulocyte count of patients during hospitalization, at discharge and two weeks after discharge were evaluated. All patients received standard treatment for acute hemolysis.
Results: Mean age of the patients was 44.19± 16.43 months. There was no significant difference between 4 groups in terms of age, gender, and etiology of hemolysis (p>0.05). The consumption of fava bean was the main cause of hemolysis in 95% of patients. The level of hemoglobin and hematocrit, and reticulocyte count during hospitalization and discharge among groups showed no significant difference (p>0.05). However, a significant increase was observed in the level of hemoglobin and hematocrit and reduction of reticulocyte count in patients receiving supplements compared with control group (p=0.001).
Conclusion: Considering the low cost, availability, and safety profile of theses supplements, it seems that usage of folic acid and vitamin E can be highly recommended during favism.
Dr Bahram Darbandi, Dr Simin Sajudi, Dr Vahid Aminzadeh, Dr Kioomars Golshekan, Dr Afagh Hassanzadeh Rad, Dr Adel Baghersalimi,
Volume 9, Issue 3 (6-2019)
Abstract
Background: Storage of platelet concentrates (PCs) at room temperature (20-24°C) limits its storage time to 5 Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common inherited enzyme deficiency of the human red blood cells . Most of G6PD deficient individuals are asymptomatic, but acute hemolytic anemia may be presented with nausea, vomiting, abdominal pain, headache, jaundice, pallor, discoloration of the urine, chills, and fever. Seizure is reported as a rare symptom, as well. The present study aimed to investigate seizure following acute hemolysis caused by Glucose-6-phosphate dehydrogenase deficiency.
Material and Methods: This analytic cross-sectional study was conducted on all consecutive patients aged 1-12 years with G6PD deficiency hospitalized for hemolysis in 17 Shahrivar children hospital, Rasht, Iran, in 2016. Demographic characteristics and other variables such as place of inhabitants, type of drinking water, history of seizure in the patients and family, cause of hemolysis, hemoglobin level and hemoglobinuria on admission, and infection history prior to hemolysis were recorded. Data were analyzed by Mann-Whitney U test and Fischer Exact Test. P-value < 0.05 indicated statistical significance and data were assessed by SPSS (version 20).
Results: The youngest patient was one year old and the oldest was 11 years old. Most of them were males (68.9%). Out of 244 patients, 8 ones (3.3%) experienced seizure. There was a significant correlation between seizure occurrence and family history of seizure (p=0.03) as well as fava bean consumption (p=0.019) as the causes of hemolysis; but not with infection as the cause of hemolysis, hemoglobin or hemoglobinuria level on admission, types of drinking water, place of living, and gender. Methemoglobinemia was considered as the main cause of the seizure.
Conclusion: Although the rate of seizure was not so high (3.3%), it seems that seizure can be a critical and potentially life-threatening complication in these patients. Environmental factors may also play a role in the pathogenesis of the seizure in these patients.
