Seyed Jalil Mirmohammadi, Azam Sadat Hashemi, Azadah Souzani, Khadijeh Dehghani, Atef Atefi, Zahra Zareian Yazdi,
Volume 1, Issue 1 (11-2010)
Abstract
Abstract
Objective
The incidence of childhood cancer has been increasing nearly one percent per year for the past two decades. Leukemia and lymphoma are the most common types of childhood cancers. This study assessed the relation between environmental factors (Hydrocarbon, agricultural toxin, insecticide) and leukemia/lymphoma in children, which was evaluated by the frequency of the parents’ hazardous occupations, and their smoking, drug addiction, and alcoholism habits.
Methods
This was a case-control study on 86 children with leukemia and non-Hodgkin's lymphoma and 188 healthy controls from March 2007 till March 2010. They were matched in age and sex. Information was gathered via a questionnaire and analyzed by SPSS 15.
Result
There were 32 (37.2%) girls and 54 (62.8%) boys in the case group and the majority were 3-5 years old. In case group fathers’ occupations were mostly farmers 50 (58.1%), followed by painter or exposed to hydrocarbons 14 (16.6%), but in the control group, farmers were 17 (19.7%), and painters or those exposed to hydrocarbons were 5 (5.8%). The frequency of fathers' various occupations was significantly different between cases and controls. In addition, smoking, drug addiction and alcoholism was significantly higher in cases fathers than controls fathers.
Conclusion
The frequency of leukemia and non-Hodgkin's lymphoma in children whose father were painters, exposed to hydrocarbons and farmers are higher than normal children. So people with these occupations should pay more attention and should be protected against these risk factors. The history of addiction and alcoholism was higher in their father.
Dr Fariba Binesh, Dr Azam Sadat Hashemi , Dr Nazila Naghibzadeh, Mrs Fatemeh Pourhosseini , Dr Sara Mirhosseini ,
Volume 10, Issue 4 (10-2020)
Abstract
Background: Given that Hodgkin’s lymphoma (HL) accounts for 5%–6% of pediatric malignancies, we investigated the clinical characteristics and survival of pediatric patients with HL in our center.
Materials and methods: In this cross sectional and retrospective study, the medical charts of all patients under the age of 18 diagnosed with HL from 2006 to 2016 at Shahid Sadoughi Hospital Yazd, Iran, were retrieved. Data were analyzed by SPSS (version 18) using K square and T-Test. Survival was analyzed using Kaplan-Meier estimates, and multivariate analysis was performed using the Cox regression method.
Results: This study included 34 patients. In terms of gender, there were 20 boys and 14 girls in this study. The mean age of the patients was 10.42 years. The most common subtype of HL was mixed cellularity. Regarding disease stage, 55.9% of the patients were in stage I. All subtypes except for nodular sclerosis were more common in boys. The mean survival of patients in this study was 151.68 months. At the end of the study, there was just one death. The 5-year survival of patients was 100% and the 10-year survival was 94%. There was no significant relationship between survival and sex, histologic subtype, or the stage of the disease.
Conclusion: The results of the current study showed that majority of our patients had been diagnosed in a low stage and we achieved the best results for 5- and 10- year- overall survival through applied treatment.
