Iranian journal of Pediatric Hematology and Oncology

en Serum IGF-1 and IGFBP-3 Levels Before and After Induction Chemotherapy in Children with Acute Lymphoblastic Leukemia غدد glands پژوهشي Research Background: The growth hormone–insulin-like growth factor (GH–IGF) axis is suppressed by systemic inflammation and catabolism. We assessed the dynamics of Insulin-like Growth Factor-1 (IGF-1) and Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) in children with acute lymphoblastic leukemia (ALL) at presentation and after induction chemotherapy, and we examined their relationships with disease metrics and nutritional status. Materials and Methods: In a prospective cohort with a healthy control group, we enrolled 27 pediatric ALL patients and 95 healthy children. After 2 deaths and 2 withdrawals, paired pre/post-induction analyses were performed in 23 patients. IGF-1 and IGFBP-3 were measured using a chemiluminescent immunoassay on the Immulite 2000 system at baseline and on day 33. Anthropometrics and routine disease indices (WBC, cytogenetics, DNA index, measurable residual disease (MRD) were recorded. Data were analyzed using SPSS version 26 using chi-square, Fisher’s exact test, T-test, Wilcoxon signed-rank, and Mann–Whitney U. P-value<0.05 was considered significant. Results: At diagnosis, patients had significantly lower IGF-1 (53 [34–111] vs. 168 [107.5–288] ng/mL; p < 0.001) and IGFBP-3 (1650 [1325–2890] vs. 3306 [2476–4149.5] ng/mL; p < 0.001) than controls. Following induction, IGF-1 increased from 53 [34–111] to 98 [79–138] ng/mL (p < 0.001), and IGFBP-3 from 1650 [1325–2890] to 2190 [1764–3799] ng/mL (p = 0.001). MRD status was not associated with IGF-1 (pre-induction: p = 0.459; post-induction: p = 1.000) or IGFBP-3 (pre-induction: p = 0.312; post-induction: p = 0.825) levels, or with their changes during induction (IGF-1: p = 1.000; IGFBP-3: p = 0.923). Conclusion: IGF-1 and IGFBP-3 are suppressed at diagnosis and rebound after induction in pediatric ALL. These findings demonstrate dynamic changes in IGF-1 and IGFBP-3 during induction therapy. Further longitudinal studies are needed to determine whether these biomarkers have clinical utility. <h2 style="margin-bottom:5px; margin-top:24px"></h2> Insulin-Like Growth Factor I, Insulin-Like Growth Factor Binding Protein 3, Leukemia 1021 1030 http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-636-7&slc_lang=en&sid=1 Setila Dalili Setila Dalili Setiladalili1346@yahoo.com 0000-0002-4976-1404 No Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Shahin Koohmanaee Shahin Koohmanaee koohmana@yahoo.com 0000-0001-6700-3044 No Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Mercedeh Enshaei Mercedeh Enshaei m_enshaei@gums.ac.ir 0000-0002-9201-7015 No Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Mohadeseh Safari Ghasabsaraii Mohadeseh Safari Ghasabsaraii mohaddesehsafari.1377@gmail.com 0000-0003-3460-2862 No Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Mohammad Ali Esfandiari Mohammad Ali Esfandiari maliesf99@gmail.com 0000-0001-5553-5107 No Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Ehsan Kazemnejad Leili Ehsan Kazemnejad Leili kazem_eh@yahoo.com 0000-0002-4035-2890 No Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Afagh Hassanzadeh Rad Afagh Hassanzadeh Rad afaghrad@gums.ac.ir 0000-0001-6980-8866 No Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Adel Baghersalimi Adel Baghersalimi baghersalimi498@yahoo.com 0000-0002-1279-5379 No Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Bahram Darbandi Bahram Darbandi Darbandi45@gmail.com 0000-0001-6100-6332 Yes Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran