en قلب Heart پژوهشي Research <p>Background<br> Evidence indicates RFC1 G80A&nbsp;polymorphism as a risk factor for a&nbsp;number of cancers. Increasing studies have&nbsp;been conducted on the association of&nbsp;RFC1 G80A polymorphism with acute&nbsp;lymphoblastic leukemia (ALL) risk.&nbsp;However, the results were &nbsp;controversial.&nbsp;The aim of the present study was to derive&nbsp;a more precise estimation of the&nbsp;relationship.&nbsp;</p> <p>Materials and Method<br> PubMed, Embase, Web of Science,&nbsp;Cochrane database, and Google Scholar&nbsp;were searched to get the genetic&nbsp;association studies between RFC1 G80A&nbsp;polymorphism and ALL. All eligible&nbsp;studies for the period up to February 2016&nbsp;were identified. Subgroup analyses&nbsp;regarding ethnicity were also&nbsp;implemented. All statistical analyses were&nbsp;done with CMA 2.0.<br> Results<br> A total of ten studies comprising of 2,168&nbsp;ALL cases and 2,693 healthy controls&nbsp;were included in this meta-analysis.&nbsp;Overall, no significant association was&nbsp;detected for allelic model (OR = 1.029, 95&nbsp;% CI 0.754- 1.405, P=0.000), Dominant&nbsp;model (OR = 1.619, 95 % CI 0.847-3.094,&nbsp;P=0.145), recessive model (OR = 1.169,&nbsp;95 % CI 10.764-1.790, P=0.429), and&nbsp;homozygote model (OR = 1.288, 95 % CI&nbsp;0.928-1.788, P=0.130). However, there&nbsp;was an obvious association under the&nbsp;heterozygote model (OR = 1.368, 95 % CI&nbsp;1.056- 1.772, P=0.018). Also, in the&nbsp;stratified analysis by ethnicity, no&nbsp;significant association of this&nbsp;polymorphism with risk of OC was found&nbsp;in the Asian and Caucasian populations.&nbsp;However, there was not significant<br> heterogeneity between heterozygote&nbsp;genetic model (P = 0.15, I2 = 33%) in&nbsp;Caucasian. Therefore, we utilized the&nbsp;fixed-effect model to merge OR value.<br> Conclusion<br> Based on the available evidence, no&nbsp;association between RFC1 G80A&nbsp;Polymorphism and ALL risk was&nbsp;observed, even in the subanalysis by&nbsp;ethnicity. The direction of further research&nbsp;should focus not only on the simple&nbsp;relationship of RFC1 G80A Polymorphism&nbsp;and ALL risk, but also on gene&ndash;gene and&nbsp;gene-environment interaction.</p> Acute lymphoblastic leukemia, Genetic polymorphism, G80A Polymorphism, Meta-analysis, RFC1. 52 63 http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-70-76&slc_lang=en&sid=1 M Forat-Yazdi No F Hosseini-Biouki Yes J Salehi No H Neamatzadeh No R Masoumi Dehshiri No Z Sadri No F Ghanizadeh No R Sheikhpour No H Zare-Zardini No