en قلب Heart پژوهشي Research <p><strong>Background: </strong>Acute myeloid leukemia (AML) is a malignant disorder involving blood cells, characterized by obstructed or distorted differentiation of hematopoietic stem cells. In cytogenetically normal AML (CN AML), molecular abnormalities in <em>NPM</em>, <em>FLT3</em>, <em>CEBPA</em>, and <em>BAALC</em> genes are observed. Initially, high <em>BAALC</em> (Brain and Acute Leukemia Cytoplasmic gene) expression was introduced in a study on AML cases with trisomy 8. The present systematic review aimed to determine the prognostic value of <em>BAALC</em> expression in CN-AML patients within the age range of 1 month to 15 years.</p> <p><strong>Materials and Methods: </strong>In this systematic review, scientific databases including PubMed, Scopus, Embase, ISI, and Cochrane Library were searched. All the evaluated retrospective studies focused on the prognostic value of <em>BAALC</em> expression.</p> <p><strong>Results: </strong>Overall, <em>BAALC</em> expression was reported in 30-60% of AML patients (mean=45%). High expression of <em>BAALC</em> gene was reported in M0, M1, and M2 subtypes of pediatric AML. In only one study, in addition to these subtypes, M4 was also reported (12.5% of cases).</p> <p><strong>Conclusion: </strong>This systematic review resulted in a significant association between high <em>BAALC</em> expression and poor response to chemotherapy in pediatric AML. However, OS (Overall Survival) and EFS (Event - Free Survival) findings were contradictory, relapse and death increase in the presence of high <em>BAALC</em> expression. Therefore, <em>BAALC</em> expression could be considered as a clinical prognostic marker for the treatment of AML patients. Further efficient prognostic indicators should be identified in order to gather information about therapeutic strategies for AML and risk analysis in these patients.</p> <p></p> BAALC, Expression, Pediatric AML and Prognosis. 129 135 http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-70-81&slc_lang=en&sid=1 Hossein Ayatollahi حسین ایت اللهی No Maliheh Hasheminezhad ملیحه هاشمی نژاد No Arezoo Shojaiee آرزو شجاعی No Mohammad Hadi Sadeghian محمدهادی صادقیان No Ehsan Yazdandoust احسان یزدان دوست No Maryam Sheikhi مریم شیخی Yes Sepideh Shakeri سپیده شاکری No Seyede Fatemeh Sams سیده فاطمه سمس No