en قلب Heart پژوهشي Research <p style="text-align: justify;"><strong>Abstract<br> Background: </strong></p> <p style="text-align: justify;">Thalassemias are the most common inherited blood disorders caused by some mutations which can reduce the synthesis of globin chains. Iron overload and its organ deposition are responsible for functional abnormalities and tissue injury in patients who affected by &beta;-thalassemia major. The aim of this case-control study was evaluation of hematological parameters, oxidative stress and some serum liver and kidney risk factors which play crucial role for early prediction and prevention of patients to end-stage tissue failure and mortality.<br> <strong>Materials and Methods: </strong></p> <p style="text-align: justify;">the present study consisted of Fifty young adult subjects with &beta;-thalassemia major (&beta;- TM) (aged<18 years) and same number age and sex- matched healthy subjects as control group. Hematological and biochemical laboratory parameters included Urea, Creatinine, Uric Acid, Aspartate Aminotransferase (AST), Alanine transaminase (ALT), Alkaline phosphatase (ALP) (pars azmoon kit), oxidative stress biomarker PAB, giving a redox index (chemically), and serum high-sensitivity C-reactive protein (hs-CRP) were evaluated.<br> <strong>Results: </strong></p> <p style="text-align: justify;">Urea, Creatinine and Uric Acid were significantly decreased in patients group (P<0.001); in spite of, serum ferritin, liver biomarkers AST, ALT, ALP and risk factor biomarker PAB were statistically increased in patients versus control group(P<0.001), whereas hs-CRP(P>0.05) was not significantly difference in study groups. Exception hs-CRP and PAB (P>0.05), liver risk factors had a positive correlation with ferritin and serum Urea, Creatinine and Uric Acid tests had negative meaningful with hematological parameters (P<0.001). Likewise, PAB with AST showed a positive correlation (P<0.001) and irreversibly with urea and creatinine (P<0.001). We did not find a slight correlation between hs-CRP in the company to hematological and biochemical laboratory finding (P>0.05).</p> <p style="text-align: justify;"><strong>Conclusion: </strong></p> <p style="text-align: justify;">Higher level of risk factors PAB values and key liver enzyme profiles are able to involve in the prognostic pathological consequences in patients with &beta;-thalassemia major. Even so, they contribute toward the gradual development of tissue injuries.</p> Beta-Thalassemia Major, Kidney, Liver, Inflammatory, Oxidative Stress 249 260 http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-70-101&slc_lang=en&sid=1 Mehrnoosh Shanaki No Department of medical laboratory sciences, school of allied medical sciences, shahid Beheshti University of medical sciences, Tehran, Iran دانشگاه علوم پزشکی شهید بهشتی Hassan Ehteram No Department of pathology, School of medicine, Kashan University of Medical Sciences, Kashan, Iran دانشگاه علوم پزشکی کاشان Hajar Nasiri No Hematology-Oncology and Stem cell Transplantation Research Center, Tehran university of Medical Science, Tehran, Iran دانشگاه علوم پزشکی تهرن Mehdi Azad No Department of Medical laboratory sciences, Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran ویندانشگاه علوم پزشکی قزوین Fatemeh Kouhkan No Department of Molecular Biology and Genetic Engineering, Stem Cell Technology Research Center, Tehran, Iran مرکز تحقیقات سلول های بنیادی Reza Pakzad Yes Metabolic Disorders Research Center, Department of biochemistry, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran دانشگاه علوم پزشکی گلستان Naser Mobarra No Department of Epidemiology, Faculty of Public Health, Ilam University of Medical Sciences, Ilam, Iran7. Metabolic Disorders Research Center, Department of biochemistry, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran دانشگاه علوم پزشکی گلستان