en پروپتوز به عنوان تظاهر اولیه لوسمی لنفوبلاستیک حاد در یک کودک سالم: گزارش مورد و مرور مطالعات پیشین عمومى General گزارش مورد case report Acute lymphocytic leukemia (ALL) is one of the frequent malignancies in pediatrics and involves bone marrow and extramedullary sites. Proptosis as extramedullary involvement of leukemia usually present in acute and chronic myeloid leukemia. It is extremely rare for ALL to present initially as proptosis.Here, a-21-month-old boy was presented with proptosis without any associated symptoms except lymphadenopathy. He was referred with the impression of malignancy from an ophthalmologist. After bone marrow biopsy which showed 33% blast cells, all positive for CD10, CD19, and CD79, the diagnosis of pre-B cell ALL was finally made. His symptoms were improved completely 16 days after starting standard protocol for ALL.Afterone-year follow-up, he was free of any symptoms.According to this initial presentation of ALL and no typical associated symptoms, it is important to make rapid diagnosis and start the treatment in the childhood.<br> &nbsp; Acute lymphoblastic leukemia, Proptosis, Childhood 69 73 http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-326-1&slc_lang=en&sid=1 Kourosh Goudarzipour drkgoudarzipour@yahoo.com No Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran. Shahid Beheshti University of Medical Science Ahmad Mohammadi ahmadm_59@yahoo.com No Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran. Shahid Beheshti University of Medical Science Reza Taherian taherian.reza72@gmail.com No Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Shahid Beheshti University of Medical Sciences Mehran Arabahmadi mehran_arabahmadi@yahoo.com : 0000-0001-9695-1705. Yes Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Shahid Beheshti University of Medical Sciences Behdad Behnam Behdadbehnam10@yahoo.com No Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Shahid Beheshti University of Medical Sciences Niloofar Ayoobi Yazdi No Department of Radiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran Tehran University of Medical Sciences