en قلب Heart پژوهشي Research <p>Natural killer (NK) cells are effector cells of the innate immune system that exert direct cytotoxic functions. Ubiquitously-expressed toll-like receptors (TLRs) have been recognized as one of the major components promoting dendritic cell (DC) maturation, which may induce polarized immune responses beneficial to cancer immunotherapy. TLR-activated NK cells and DCs are prerequisite for robust activation of the innate immune system against tumors. Recently, some medical research and clinical trials have proposed NK cells as a new therapy and potential strategy in both children and adults with those cancers which cannot be cured with the usual treatment modalities. As an example, the importance of DC/NK antitumor immunity in the outcome of breast and other cancers is recently recognized. Therefore, considering strategies which exploit TLR-mediated immunity in concordance with DC/NK system holds strong potential for cancer therapy. This review addresses the current knowledge about the potential role of TLR in tumor immunotherapy</p> Dendritic Cell, Immune System, Natural Killer Cell, Toll-like Receptor, Tumor 180 192 http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-70-130&slc_lang=en&sid=1 Fatemeh Pourrajab No Department of Biochemistry and Molecular Biology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Parisa i Yazdani Elahabad No School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Seyedhossein Hekmatimoghaddam Yes Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran