en گزارش یک مورد کودک ناقل هموگلوبین دانشگاه تهران در شمال ایران قلب Heart گزارش مورد case report <div>There are more than 400 different variations on &alpha;-globin protein, and most of them are not associated with noticeable clinical manifestation. Hemoglobin (Hb) is an oxygen-transporting protein and Hb Daneshgah- Tehran is an &alpha;-globin variant that for the first time was reported from Iran in a case with normal haematological indices. The capillary electrophoresis of an 8-year- old-girl with normal hematological parameters showed a peak in the location of Hb S (19.2%) with small amount of Hb A2 variant. The sequencing analysis indicated that the patient was heterozygote for Hb Daneshgah- Tehran (HBA1:c.218A>G p.His72Arg). Alpha and beta thalassemia are common health problems in north of Iran, and about 15% of Mazandarani people are carriers for alpha globin gene deletions, hence premarital screening program can help diagnosis of common and rare hemoglobinopathies. This case was the first report on Hb Daneshgah- Tehran from Mazandaran and the second one from Iran. The presented case showed that Hb Daneshgah- Tehran had haematological indices in normal range, and for the detection of this Hb variant, electrophoresis and PCR sequencing methods should be applied.</div> Alpha-globin, Capillary electrophoresis, Hemoglobin 200 202 http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-544-1&slc_lang=en&sid=1 Hossein Jalali Hossein.jalaliakerdi@gmail.com 0000-0002-2605-6227 No Student Research Committee, Thalassemia Research Center, Mazandaran University of Medical Sciences, Sari, Iran Student Research Committee, Thalassemia Research Center, Mazandaran University of Medical Sciences, Sari, Iran Mohammad Reza Mahdavi Mahdavi899@gmail.com 0000-0002-1453-5570 Yes Thalassemia Research Center, Mazandaran University of Medical Sciences, Sari, Iran Thalassemia Research Center, Mazandaran University of Medical Sciences, Sari, Iran Hossein Karami Hossein.karami@yahoo.com 0000-0001-5804-6712 No Thalassemia Research Center, Mazandaran University of Medical Sciences, Sari, Iran Thalassemia Research Center, Mazandaran University of Medical Sciences, Sari, Iran