en عمومى General پژوهشي Research <div><strong>Background: </strong>Nausea and vomiting are the common side-effects of chemotherapy in children with malignancy. In this study, the effectiveness of vitamin B6 in reducing the chemo-induced nausea and vomiting (CINV) in children was tested.<br> <strong>Material and methods: </strong>A triple-blind clinical trials was performed on 100 children with malignancy referring to the pediatric clinic of Amir Kabir Hospital, Arak, Iran. Besides the infusion of granisetron (3mg/3ml) half an hour before each chemotherapy cycle, an intravenous dose of vitamin B6 (100 mg for children from 2 to 5 years old, 200 mg for children from 5 to 10 years old, and 300 mg for children older than 10) was given 6 hours before the first chemotherapy cycle and placebo was injected (2-5 years old: 100 mg, 5-10 years old: 200 mg, age&ge; 10 years old: 300mg) 6 hours before the second cycle. Then the severity of nausea and the frequency of vomiting episodes in each cycle were recorded to be compared.<br> <strong>&nbsp;Results: </strong>The mean age of children was 7.98 &plusmn; 3.133 years old. The most common and rare malignancy were acute lymphocytic leukemia (ALL) (46%) and ependymoma (0.5%), respectively. Vincristin was the most commonly used chemotherapy agent (28%). A positive correlation between the severity of nausea(R=0.313, P-value=0.0016) and frequency of vomiting with age was found (R=0.319, P-value=0.0012). However, no noticeable association was observed between N/V and gender (P-value.0.05). There was a considerable correlation between the frequency of vomiting and different tumor types in this study (P-value=0.0006).In comparison with placebo, Vitamin B6 significantly reduced the severity of nausea (P = 0.0001) as well as the frequency of vomiting (P-value = 0.0005). It was also more effective in ALL compared to rhabdomyosarcoma (P-value=0.001).<br> <strong>Conclusion: </strong>This study suggested that vitamin B6 can be considered as an appropriate alternative to treat CINV in children with malignancy.</div> Chemotherapy, Children, Vitamin B6, Vomiting 1 9 http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-721-1&slc_lang=en&sid=1 Morteza Mousavi_hasanzadeh morteza.mousavi1993@gmail.com No Student Research Committee, Arak University of Medical Sciences, Arak, Iran Arak University of Medical Sciences Arefeh Adelnia Adelnia273@yahoo.com No Student Research Committee, Arak University of Medical Sciences, Arak, Iran Arak University of Medical Sciences Golrokh Farokhmehr No Veterinary Student, Faculty of Veterinary Medicine, Islamic Azad University, Urmia, Iran. Veterinary Student, Faculty of Veterinary Medicine, Islamic Azad University, Urmia, Iran. Sarvenaz Mehrabi sarvenazmehrabi@gmail.com No , Student Research Committee, Arak University of Medical Sciences, Arak, Iran Arak University of Medical Sciences Siam Zahedi No Student Research Committee, Arak University of Medical Sciences, Arak, Iran Arak University of Medical Sciences Aigin Eghbali aigineghbali@yahoo.com No Students Research Committee, school of medicine, Iran university of Medical Sciences, Tehran, Iran Iran university of Medical Sciences Aziz Eghbali Dr.eghbali@arakmu.ac.ir 0000-0002-5118-0094 Yes Clinical Research Development Center of Amirkabir Hospital, Arak University of Medical Sciences, Arak, Iran Arak University of Medical Sciences