fa عمومى General پژوهشي Research <div>Improved survival among transfusion dependent thalassemia patients in recent years has led to the manifestation of morbidities such as renal dysfunction. Renal injury is still an underestimated complication in &beta; thalassemia major patients. Chronic anemia, iron overload due to repeated transfusion, and specific iron chelators are the main factors in pathogenesis of renal dysfunction in &beta; thalassemia. Early identification of this morbidity allows us to delay the progression of kidney damage and therefore reduce renal impairment. In recent decades , novel biomarkers for early recognition of renal dysfunction have been studied in thalassemic patients, such as cystatin C, beta 2 microglobulin , alpha 1 microglobulin, N-acetyl beta-D-glucosaminidase (NAG), neutrophil gelatinase associated lipocaline (NGAL) , kidney injury molecule 1 (KIM-1) , liver type fatty acid binding protein (L-FABP), and retinol binding protein (RBP). In this review, renal aspects of thalassemia with focus on novel biomarkers were discussed.</div> : β thalassemia , Biomarkers, Renal Insufficiency 57 68 http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-686-3&slc_lang=fa&sid=1 Mozhgan Hashemieh 0000-0003-1109-7285 Yes Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Shahid Beheshti University of Medical Sciences