Iranian journal of Pediatric Hematology and Oncology

en Comparison of the effects of two different doses of Filgrastim in febrile neutropenia management in childhood malignancy: A randomized clinical trial قلب Heart پژوهشي Research <div style="border:double windowtext 1.5pt; padding:1.0pt 4.0pt 1.0pt 4.0pt">Background: Febrile neutropenia (FN) is most often caused due to chemotherapy. Solid or certain lymphoproliferative malignancies can increase the duration of hospitalization and other complications in cancer patients. Filgrastim is used in childhood FN management. This study aimed to compare the effect of two different doses of Filgrastim on hematological and paraclinical factors in hospitalized febrile neutropenic patients with cancer.  Materials and methods: In this randomized clinical trial, 60 febrile neutropenic patients with cancer complying with the inclusion criteria were assigned to both groups A and B. Thirty patients in group A received Filgrastim 5μg/kg/day whereas 30 others in group B received Filgrastim 15μg/kg/day. Hematological factors, physical examination findings, antibiotic administration period, and type of malignancy were then recorded. Complete blood count with differential (CBC diff) was also tested. Lung infiltration was examined by chest X-ray (CXR), and the spleen and abdomen were monitored by ultrasound. Results: The mean age of patients was 6 ± 3 years old. The most prevalent malignancies included acute lymphoblastic leukemia (ALL) (35.0%), neuroblastoma (18.3%), osteosarcoma (11.7%), acute myeloid leukemia (AML) (8.3%), and Rhabdomyosarcoma (8.3%). The frequency distribution of malignancies significantly differed between the two groups (P= .01). Changes in hematological factors, including white blood cells (WBC), mature neutrophil cells, and absolute neutrophil count (ANC) in group A, appeared lower than those in the other group. However, none of the studied factors, including hematological factors, physical examination findings, and antibiotic administration period, were found to differ significantly between the two groups (P> 0.05). Conclusion: Much as a higher dose of Filgrastim seems to bear a better effect on ANC, no significant difference was identified between the two groups. Further studies should be designed with a larger population to address the issue.  </div> Cancer, Filgrastim, Febrile neutropenia, Hematological factors 145 151 http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-25-2&slc_lang=en&sid=1 Nargesbeigom Mirbehbahani n.mirbehbahani@gmail.com 0000-0002-3782-0120 No 1Professor, MD, Neonatal and Children’s Health Research Center, Golestan University of Medical Sciences, Gorgan, Iran 1Professor, MD, Neonatal and Children’s Health Research Center, Golestan University of Medical Sciences, Gorgan, Iran Sepide Bagheri sepidehbagheri1709@yahoo.com 0000-0001-6750-2214 No MD, Golestan University of Medical Sciences, Gorgan, Iran MD, Golestan University of Medical Sciences, Gorgan, Iran Gholamreza Roshandel roshandel-md@yahoo.com 0000-0002-5494-0722 No Ph.D, Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran. Azam Jahazi No Gorgan Branch, Islamic Azad University, Gorgan, Iran Gorgan Branch, Islamic Azad University, Gorgan, Iran Azam Rashidbaghan rashidbaghan@yahoo.com 0000-0002-8933-4765 Yes 4Ph.D candidate, Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran 4Ph.D candidate, Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran