Iranian journal of Pediatric Hematology and Oncology

en Hematopoietic stem cell transplant therapy, clinical trials, complications, and quality of life for patients with Sickle cell anemia: Clinical potential and future perspectives عمومى General پژوهشي Research <div style="border:double windowtext 1.5pt; padding:1.0pt 4.0pt 1.0pt 4.0pt">Background: Sickle cell anemia (SCA) is an inherited monogenic disorder. The clinical symptoms of SCA are protean, including vaso-occlusion, hemolysis, early stroke, leg ulcers, multi-organ failure, and increased risk of premature death. Hematopoietic stem cell transplantation is the only treatment identified to reduce SCA-related organ damage. Unfortunately, graft rejection is a significant impediment to these strategies. Materials and Methods: The current standard of treatment for the past two decades is limited to myeloablative-matched sibling donors, which is likely to be only for minor patients and is feasible for non-malignant giant disease. Cumulative studies showed that HSCT increases overall survival and quality of life in patients with SCA. Results: Hematopoietic stem cell transplantation (HSCT) is significantly associated with a higher risk of graft versus host disease and moderate mortality risk. New strategy lacking standard donors includes cord blood, matched unrelated donors/ Haploidentical donors. Conclusion: This review summarized evidence from HSCT clinical trials from different transplantation methods, specific HSCT and HSCT-related health problems that need to be addressed in medical contexts with patients and family members, and other areas that enhance the quality of life in SCA.</div> Hemoglobinopathy, Hematopoietic stem-cell transplantation, Quality of Life, Sickle cell Anemia 272 302 http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-871-1&slc_lang=en&sid=1 Henu kumar verma henu.verma@yahoo.com 0000-0003-1130-8783 Yes Department of Immunopathology, Institute of lungs Biology and Disease, Comprehensive Pneumology Center, Helmholtz Zentrum, 85764 Neuherberg, Munich, Germany Department of Immunopathology, Institute of lungs Biology and Disease, Comprehensive Pneumology Center, Helmholtz Zentrum, 85764 Neuherberg, Munich, Germany Yashwant Kumar Ratre yashwntratre@gmail.com No Department of Biotechnology, Guru GhasidasVishwavidyalaya, Bilaspur, India. Department of Biotechnology, Guru GhasidasVishwavidyalaya, Bilaspur, India. Bhaskar Lvks lvksbhaskar@gmail.com No Department of Zoology, Guru GhasidasVishwavidyalaya, Bilaspur, India Department of Zoology, Guru GhasidasVishwavidyalaya, Bilaspur, India Tarun sahu tarun.sahu50@gmail.com No Department of Physiology, AIIMS, Raipur, India Department of Physiology, AIIMS, Raipur, India Devendra Purushottam Lingojwar researchpune@gmail.com No Regional Society for Education and Research in Community Health, Pune, India Regional Society for Education and Research in Community Health, Pune, India